Lidocaine Inhibits HCN Currents in Rat Spinal Substantia Gelatinosa Neurons

Lidocaine, which blocks voltage-gated sodium channels, is widely used in surgical anesthesia and pain management. Recently, it has been proposed that the hyperpolarization-activated cyclic nucleotide (HCN) channel is one of the other novel targets of lidocaine. Substantia gelatinosa in the spinal do...

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Veröffentlicht in:	Anesthesia and analgesia 2016-04, Vol.122 (4), p.1048-1059
Hauptverfasser:	Hu, Tao, Liu, Nana, Lv, Minhua, Ma, Longxian, Peng, Huizhen, Peng, Sicong, Liu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetic Pharmacology Anesthetics, Local - pharmacology Animals Cells, Cultured Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology Lidocaine - pharmacology Male Neurons - drug effects Neurons - physiology Rats Rats, Sprague-Dawley Research Report Substantia Gelatinosa - drug effects Substantia Gelatinosa - physiology
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