Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats

Hypertension is associated with increased levels of circulating cytokines and recent studies have shown that innate immunity contributes to hypertension. The mechanisms which hypertension stimulates immune response remain unclear, but may involve formation of neo-antigens that activate the immune sy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Life sciences (1973) 2015-02, Vol.122, p.1-7
Hauptverfasser:	Bomfim, G.F., Echem, C., Martins, C.B., Costa, T.J., Sartoretto, S.M., Dos Santos, R.A., Oliveira, M.A., Akamine, E.H., Fortes, Z.B., Tostes, R.C., Webb, R.C., Carvalho, M.H.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal disease models Animals antibodies Antibodies, Monoclonal - pharmacology blood pressure Blood Pressure - drug effects Blotting, Western Cells, Cultured Cytokines - metabolism genes Hypertension Hypertension - immunology Hypertension - metabolism Hypertension - prevention & control immune response immune system immunoglobulin G inflammation Inflammation - immunology Inflammation - metabolism Inflammation - prevention & control Innate immune response innate immunity interleukin-6 ligands lipopolysaccharides Male mesenteric arteries Mesenteric Arteries - drug effects Mesenteric Arteries - immunology Mesenteric Arteries - metabolism NF-κB norepinephrine phosphorylation Phosphorylation - drug effects Rats Rats, Inbred SHR Rats, Wistar Reactive Oxygen Species - metabolism signal transduction Signal Transduction - drug effects Toll-like receptor Toll-like receptor 4 Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - immunology Toll-Like Receptor 4 - metabolism transcription (genetics) transcription factor NF-kappa B
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!