Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches
AIM: To explore probable mechanism underlying the therapeutic effect of Astragalus polysaccharide(APS) against experimental colitis.METHODS: Thirty-two Sprague-Dawley rats were randomly divided into four groups. Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS). The rats with coli...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2016-03, Vol.22 (11), p.3175-3185 |
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| creator | Zhao, Hai-Mei Wang, Yan Huang, Xiao-Ying Huang, Min-Fang Xu, Rong Yue, Hai-Yang Zhou, Bu-Gao Huang, Hong-Yan Sun, Qi-Meng Liu, Duan-Yong |
| description | AIM: To explore probable mechanism underlying the therapeutic effect of Astragalus polysaccharide(APS) against experimental colitis.METHODS: Thirty-two Sprague-Dawley rats were randomly divided into four groups. Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS). The rats with colitis were treated with 400 mg/kg of APS for 7 d. The therapeutic effect was evaluated by colonic weight, weight index of the colon, colonic length, and macroscopic and histological scores. The levels of regulatory T(Treg) cells in Peyer’s patches were measured by flow cytometry, and cytokines in colonic tissue homogenates were analyzed using enzyme-linked immunosorbent assay. The expression of related orphan receptor-gt(ROR-gt), IL-23 and STAT-5a was measured by Western blot.RESULTS: After 7-d treatment with APS, the weight index of the colon, colonic weight, macroscopical and histological scores were decreased, while the colonic length was increased compared with the model group. The expression of interleukin(IL)-2, IL-6, IL-17, IL-23 and ROR-gt in the colonic tissues was down-regulated, but Treg cells in Peyer’s patches, TGF-β and STAT5 a in the colonic tissues were up-regulated.CONCLUSION: APS effectively ameliorates TNBSinduced experimental colitis in rats, probably through restoring the number of Treg cells, and inhibiting IL-17 levels in Peyer’s patches. |
| doi_str_mv | 10.3748/wjg.v22.i11.3175 |
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Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS). The rats with colitis were treated with 400 mg/kg of APS for 7 d. The therapeutic effect was evaluated by colonic weight, weight index of the colon, colonic length, and macroscopic and histological scores. The levels of regulatory T(Treg) cells in Peyer’s patches were measured by flow cytometry, and cytokines in colonic tissue homogenates were analyzed using enzyme-linked immunosorbent assay. The expression of related orphan receptor-gt(ROR-gt), IL-23 and STAT-5a was measured by Western blot.RESULTS: After 7-d treatment with APS, the weight index of the colon, colonic weight, macroscopical and histological scores were decreased, while the colonic length was increased compared with the model group. The expression of interleukin(IL)-2, IL-6, IL-17, IL-23 and ROR-gt in the colonic tissues was down-regulated, but Treg cells in Peyer’s patches, TGF-β and STAT5 a in the colonic tissues were up-regulated.CONCLUSION: APS effectively ameliorates TNBSinduced experimental colitis in rats, probably through restoring the number of Treg cells, and inhibiting IL-17 levels in Peyer’s patches.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v22.i11.3175</identifier><identifier>PMID: 27003994</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Astragalus ; Astragalus membranaceus - chemistry ; Basic Study ; cells;Interleukin-17 ; Colitis - chemically induced ; Colitis - drug therapy ; Colitis - immunology ; Colitis - metabolism ; Colon - drug effects ; Colon - immunology ; Colon - metabolism ; Colon - pathology ; Cytokines - immunology ; Cytokines - metabolism ; Disease Models, Animal ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Male ; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism ; Peyer's Patches - drug effects ; Peyer's Patches - immunology ; Peyer's Patches - metabolism ; Phosphorylation ; Phytotherapy ; Plants, Medicinal ; polysaccharide;Colitis;Regulatory ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Rats, Sprague-Dawley ; STAT5 Transcription Factor - metabolism ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; Trinitrobenzenesulfonic Acid</subject><ispartof>World journal of gastroenterology : WJG, 2016-03, Vol.22 (11), p.3175-3185</ispartof><rights>The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-5dd854135cd1fcc4668c6bd9ecfb13bedaf73762e97a45d53b229ed65126083b3</citedby><cites>FETCH-LOGICAL-c398t-5dd854135cd1fcc4668c6bd9ecfb13bedaf73762e97a45d53b229ed65126083b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789992/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789992/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27003994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Hai-Mei</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Huang, Xiao-Ying</creatorcontrib><creatorcontrib>Huang, Min-Fang</creatorcontrib><creatorcontrib>Xu, Rong</creatorcontrib><creatorcontrib>Yue, Hai-Yang</creatorcontrib><creatorcontrib>Zhou, Bu-Gao</creatorcontrib><creatorcontrib>Huang, Hong-Yan</creatorcontrib><creatorcontrib>Sun, Qi-Meng</creatorcontrib><creatorcontrib>Liu, Duan-Yong</creatorcontrib><title>Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To explore probable mechanism underlying the therapeutic effect of Astragalus polysaccharide(APS) against experimental colitis.METHODS: Thirty-two Sprague-Dawley rats were randomly divided into four groups. Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS). The rats with colitis were treated with 400 mg/kg of APS for 7 d. The therapeutic effect was evaluated by colonic weight, weight index of the colon, colonic length, and macroscopic and histological scores. The levels of regulatory T(Treg) cells in Peyer’s patches were measured by flow cytometry, and cytokines in colonic tissue homogenates were analyzed using enzyme-linked immunosorbent assay. The expression of related orphan receptor-gt(ROR-gt), IL-23 and STAT-5a was measured by Western blot.RESULTS: After 7-d treatment with APS, the weight index of the colon, colonic weight, macroscopical and histological scores were decreased, while the colonic length was increased compared with the model group. The expression of interleukin(IL)-2, IL-6, IL-17, IL-23 and ROR-gt in the colonic tissues was down-regulated, but Treg cells in Peyer’s patches, TGF-β and STAT5 a in the colonic tissues were up-regulated.CONCLUSION: APS effectively ameliorates TNBSinduced experimental colitis in rats, probably through restoring the number of Treg cells, and inhibiting IL-17 levels in Peyer’s patches.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Astragalus</subject><subject>Astragalus membranaceus - chemistry</subject><subject>Basic Study</subject><subject>cells;Interleukin-17</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colitis - immunology</subject><subject>Colitis - metabolism</subject><subject>Colon - drug effects</subject><subject>Colon - immunology</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Inflammation Mediators - immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Male</subject><subject>Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism</subject><subject>Peyer's Patches - drug effects</subject><subject>Peyer's Patches - immunology</subject><subject>Peyer's Patches - metabolism</subject><subject>Phosphorylation</subject><subject>Phytotherapy</subject><subject>Plants, Medicinal</subject><subject>polysaccharide;Colitis;Regulatory</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Rats, Sprague-Dawley</subject><subject>STAT5 Transcription Factor - metabolism</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>Trinitrobenzenesulfonic Acid</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUc2OFCEYJEbjjqt3T4ajlx75beBistnoarKJHtYzoYHuYdPTzAK92okHX2NfzyeRzo4TBb5w-KrqoygAXmO0pYLJd99vh-09IduA8ZZiwZ-ADSFYNUQy9BRsMEKiUZSIM_Ai51uECKWcPAdnRCBElWIb8PMil2QGM84ZHuK4ZGPtzqTgPDSl-Gk2xWeYTIH-x8GnsPdTMSO0cQwlZNgtMExutmEaYPLDPJoS0wJvoPXjmGuvnipQwlRJX_3i0-9fD3WSKXbn80vwrDdj9q-O9zn49vHDzeWn5vrL1efLi-vGUiVLw52TnGHKrcO9taxtpW07p7ztO0w770wvqGiJV8Iw7jjtCFHetRyTFkna0XPw_lH3MHd772z1kMyoD9WOSYuOJuj_O1PY6SHeayakUopUgbdHgRTv5upH70NeLZrJxzlrLARviaIcVSh6hNoUc06-P43BSK-h6RqarqHpGppeQ6uUN_8-70T4m1IF0KPmLk7DXf3sE0YhuS7FEZNMccZU3XIt-gfHzakq</recordid><startdate>20160321</startdate><enddate>20160321</enddate><creator>Zhao, Hai-Mei</creator><creator>Wang, Yan</creator><creator>Huang, Xiao-Ying</creator><creator>Huang, Min-Fang</creator><creator>Xu, Rong</creator><creator>Yue, Hai-Yang</creator><creator>Zhou, Bu-Gao</creator><creator>Huang, Hong-Yan</creator><creator>Sun, Qi-Meng</creator><creator>Liu, Duan-Yong</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160321</creationdate><title>Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches</title><author>Zhao, Hai-Mei ; Wang, Yan ; Huang, Xiao-Ying ; Huang, Min-Fang ; Xu, Rong ; Yue, Hai-Yang ; Zhou, Bu-Gao ; Huang, Hong-Yan ; Sun, Qi-Meng ; Liu, Duan-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-5dd854135cd1fcc4668c6bd9ecfb13bedaf73762e97a45d53b229ed65126083b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Astragalus</topic><topic>Astragalus membranaceus - chemistry</topic><topic>Basic Study</topic><topic>cells;Interleukin-17</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colitis - immunology</topic><topic>Colitis - metabolism</topic><topic>Colon - drug effects</topic><topic>Colon - immunology</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Inflammation Mediators - immunology</topic><topic>Inflammation Mediators - metabolism</topic><topic>Male</topic><topic>Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism</topic><topic>Peyer's Patches - drug effects</topic><topic>Peyer's Patches - immunology</topic><topic>Peyer's Patches - metabolism</topic><topic>Phosphorylation</topic><topic>Phytotherapy</topic><topic>Plants, Medicinal</topic><topic>polysaccharide;Colitis;Regulatory</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Rats, Sprague-Dawley</topic><topic>STAT5 Transcription Factor - metabolism</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>Trinitrobenzenesulfonic Acid</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Hai-Mei</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Huang, Xiao-Ying</creatorcontrib><creatorcontrib>Huang, Min-Fang</creatorcontrib><creatorcontrib>Xu, Rong</creatorcontrib><creatorcontrib>Yue, Hai-Yang</creatorcontrib><creatorcontrib>Zhou, Bu-Gao</creatorcontrib><creatorcontrib>Huang, Hong-Yan</creatorcontrib><creatorcontrib>Sun, Qi-Meng</creatorcontrib><creatorcontrib>Liu, Duan-Yong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Hai-Mei</au><au>Wang, Yan</au><au>Huang, Xiao-Ying</au><au>Huang, Min-Fang</au><au>Xu, Rong</au><au>Yue, Hai-Yang</au><au>Zhou, Bu-Gao</au><au>Huang, Hong-Yan</au><au>Sun, Qi-Meng</au><au>Liu, Duan-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2016-03-21</date><risdate>2016</risdate><volume>22</volume><issue>11</issue><spage>3175</spage><epage>3185</epage><pages>3175-3185</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM: To explore probable mechanism underlying the therapeutic effect of Astragalus polysaccharide(APS) against experimental colitis.METHODS: Thirty-two Sprague-Dawley rats were randomly divided into four groups. Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS). The rats with colitis were treated with 400 mg/kg of APS for 7 d. The therapeutic effect was evaluated by colonic weight, weight index of the colon, colonic length, and macroscopic and histological scores. The levels of regulatory T(Treg) cells in Peyer’s patches were measured by flow cytometry, and cytokines in colonic tissue homogenates were analyzed using enzyme-linked immunosorbent assay. The expression of related orphan receptor-gt(ROR-gt), IL-23 and STAT-5a was measured by Western blot.RESULTS: After 7-d treatment with APS, the weight index of the colon, colonic weight, macroscopical and histological scores were decreased, while the colonic length was increased compared with the model group. The expression of interleukin(IL)-2, IL-6, IL-17, IL-23 and ROR-gt in the colonic tissues was down-regulated, but Treg cells in Peyer’s patches, TGF-β and STAT5 a in the colonic tissues were up-regulated.CONCLUSION: APS effectively ameliorates TNBSinduced experimental colitis in rats, probably through restoring the number of Treg cells, and inhibiting IL-17 levels in Peyer’s patches.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>27003994</pmid><doi>10.3748/wjg.v22.i11.3175</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Astragalus Astragalus membranaceus - chemistry Basic Study cells Interleukin-17 Colitis - chemically induced Colitis - drug therapy Colitis - immunology Colitis - metabolism Colon - drug effects Colon - immunology Colon - metabolism Colon - pathology Cytokines - immunology Cytokines - metabolism Disease Models, Animal Inflammation Mediators - immunology Inflammation Mediators - metabolism Male Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Peyer's Patches - drug effects Peyer's Patches - immunology Peyer's Patches - metabolism Phosphorylation Phytotherapy Plants, Medicinal polysaccharide Colitis Regulatory Polysaccharides - isolation & purification Polysaccharides - pharmacology Rats, Sprague-Dawley STAT5 Transcription Factor - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Trinitrobenzenesulfonic Acid |
| title | Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches |
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