The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration
A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve...
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Veröffentlicht in: | Iranian journal of veterinary research 2014, Vol.15 (4), p.392-396 |
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description | A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P |
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The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P<0.05). Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group (P<0.05). Intraperitoneal administration of CoQ10 (10 mg/kg/day) in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration.</description><identifier>ISSN: 1728-1997</identifier><identifier>EISSN: 2252-0589</identifier><identifier>PMID: 27175137</identifier><language>eng</language><publisher>Iran: School of Veterinary Medicine, University of Shiraz</publisher><subject>Original</subject><ispartof>Iranian journal of veterinary research, 2014, Vol.15 (4), p.392-396</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789219/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789219/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27175137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moradi, Z</creatorcontrib><creatorcontrib>Azizi, S</creatorcontrib><creatorcontrib>Hobbenaghi, R</creatorcontrib><title>The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration</title><title>Iranian journal of veterinary research</title><addtitle>Iran J Vet Res</addtitle><description>A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P<0.05). Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group (P<0.05). Intraperitoneal administration of CoQ10 (10 mg/kg/day) in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration.</description><subject>Original</subject><issn>1728-1997</issn><issn>2252-0589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVUMlqwzAQFaWlCWl-oejYi8GSF0mXQgndINBLejaSPIoFtuRIdiB_X4WmpT3NY-ZtzBVaUlrRLK-4uEZLwijPiBBsgdYxWpXndV1WpeC3aEEZYRUp2BKZXQcYjAE9YW_wrOxhts47wN5hMzs9We9kjwNof4RwwtK1ePBh7PwAU7AaW9daDfGsjtrKKa0chCMkyR4SkmeHO3RjZB9hfZkr9PnyvNu8ZduP1_fN0zYbaV1PWVmmjjyV04bkRJpW8EJyqkQOICvNFTNGqULSikPLDC_qqpUtGCGZYgkUK_T47TvOaoBWg5uC7Jsx2EGGU-Olbf5fnO2avT82JeOCEpEMHi4GwR9miFMz2Kih76UDP8eGJF5e1IzxRL3_m_Ub8vPc4gvENnwt</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Moradi, Z</creator><creator>Azizi, S</creator><creator>Hobbenaghi, R</creator><general>School of Veterinary Medicine, University of Shiraz</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2014</creationdate><title>The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration</title><author>Moradi, Z ; Azizi, S ; Hobbenaghi, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-446648717cf101afd983a82b90eea5c8b7ffbb3a258ed7f8365dadef9a7b7ade3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moradi, Z</creatorcontrib><creatorcontrib>Azizi, S</creatorcontrib><creatorcontrib>Hobbenaghi, R</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Iranian journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moradi, Z</au><au>Azizi, S</au><au>Hobbenaghi, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration</atitle><jtitle>Iranian journal of veterinary research</jtitle><addtitle>Iran J Vet Res</addtitle><date>2014</date><risdate>2014</risdate><volume>15</volume><issue>4</issue><spage>392</spage><epage>396</epage><pages>392-396</pages><issn>1728-1997</issn><eissn>2252-0589</eissn><abstract>A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P<0.05). Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group (P<0.05). Intraperitoneal administration of CoQ10 (10 mg/kg/day) in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration.</abstract><cop>Iran</cop><pub>School of Veterinary Medicine, University of Shiraz</pub><pmid>27175137</pmid><tpages>5</tpages></addata></record> |
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title | The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration |
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