Validity of the MPTP-Treated Mouse as a Model for Parkinson’s Disease

Parkinson’s disease (PD) is characterized by dopaminergic (DA) neuron death in the substantia nigra (SN) and subsequent striatal adaptations. Mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) are widely used as a model for PD. To assess the validity of the MPTP m...

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Veröffentlicht in:	Molecular neurobiology 2016-04, Vol.53 (3), p.1625-1636
Hauptverfasser:	Klemann, Cornelius J. H. M., Martens, Gerard J. M., Poelmans, Geert, Visser, Jasper E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cell Biology Corpus Striatum - pathology Disease Models, Animal Drug Evaluation, Preclinical Epilepsy - pathology Female Gene Expression Profiling Humans Male Mice MicroRNAs Models, Neurological MPTP Poisoning - genetics MPTP Poisoning - metabolism MPTP Poisoning - pathology Nerve Tissue Proteins - metabolism Neurobiology Neurology Neurosciences Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease Parkinsonian Disorders - genetics Parkinsonian Disorders - metabolism Parkinsonian Disorders - pathology Pathogenesis Protein expression RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Transcriptome
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