Pretreatment oral hygiene habits and survival of head and neck squamous cell carcinoma (HNSCC) patients
The survival time of patients with head and neck squamous cell carcinoma (HNSCC) is related to health behavior, such as tobacco smoking and alcohol consumption. Poor oral health (OH), dental care (DC) and the frequent use of mouthwash have been shown to represent independent risk factors for head an...
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| Veröffentlicht in: | BMC oral health 2016-03, Vol.16 (33), p.33-33, Article 33 |
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| creator | Friemel, Juliane Foraita, Ronja Günther, Kathrin Heibeck, Mathias Günther, Frauke Pflueger, Maren Pohlabeln, Hermann Behrens, Thomas Bullerdiek, Jörn Nimzyk, Rolf Ahrens, Wolfgang |
| description | The survival time of patients with head and neck squamous cell carcinoma (HNSCC) is related to health behavior, such as tobacco smoking and alcohol consumption. Poor oral health (OH), dental care (DC) and the frequent use of mouthwash have been shown to represent independent risk factors for head and neck cancerogenesis, but their impact on the survival of HNSCC patients has not been systematically investigated.
Two hundred seventy-six incident HNSCC cases recruited for the ARCAGE study were followed through a period of 6-10 years. Interview-based information on wearing of dentures, gum bleeding, teeth brushing, use of floss and dentist visits were grouped into weighted composite scores, i.e. oral health (OH) and dental care (DH). Use of mouthwash was assessed as frequency per day. Also obtained were other types of health behavior, such as smoking, alcohol drinking and diet, appreciated as both confounding and study variables. Endpoints were progression-free survival, overall survival and tumor-specific survival. Prognostic values were estimated using Kaplan-Meier analysis and Cox proportional hazards regression models.
A good dental care score, summarizing annual dental visits, daily teeth cleaning and use of floss was associated with longer overall survival time (p = .001). The results of the Cox regression models similarly suggested a higher risk of tumor progression and shortened overall survival in patients with poor dental care, but the results lost their statistical significance after other types of health behavior had been controlled for. Frequent use of mouthwash (≥ 2 times/day) significantly increased the risk of tumor-specific death (HR = 2.26; CI = 1.19-4.32). Alcohol consumption and tobacco smoking were dose-dependently associated with tumor progression and shorter overall survival.
Frequent mouthwash use of ≥ 2 times/day seems to elevate the risk of tumor-specific death in HNSCC patients. Good dental care scores are associated with longer overall survival. |
| doi_str_mv | 10.1186/s12903-016-0185-0 |
| format | Article |
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Two hundred seventy-six incident HNSCC cases recruited for the ARCAGE study were followed through a period of 6-10 years. Interview-based information on wearing of dentures, gum bleeding, teeth brushing, use of floss and dentist visits were grouped into weighted composite scores, i.e. oral health (OH) and dental care (DH). Use of mouthwash was assessed as frequency per day. Also obtained were other types of health behavior, such as smoking, alcohol drinking and diet, appreciated as both confounding and study variables. Endpoints were progression-free survival, overall survival and tumor-specific survival. Prognostic values were estimated using Kaplan-Meier analysis and Cox proportional hazards regression models.
A good dental care score, summarizing annual dental visits, daily teeth cleaning and use of floss was associated with longer overall survival time (p = .001). The results of the Cox regression models similarly suggested a higher risk of tumor progression and shortened overall survival in patients with poor dental care, but the results lost their statistical significance after other types of health behavior had been controlled for. Frequent use of mouthwash (≥ 2 times/day) significantly increased the risk of tumor-specific death (HR = 2.26; CI = 1.19-4.32). Alcohol consumption and tobacco smoking were dose-dependently associated with tumor progression and shorter overall survival.
Frequent mouthwash use of ≥ 2 times/day seems to elevate the risk of tumor-specific death in HNSCC patients. Good dental care scores are associated with longer overall survival.</description><identifier>ISSN: 1472-6831</identifier><identifier>EISSN: 1472-6831</identifier><identifier>DOI: 10.1186/s12903-016-0185-0</identifier><identifier>PMID: 26969620</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Carcinoma, Squamous Cell - mortality ; Care and treatment ; Case-Control Studies ; Complications and side effects ; Dental care ; Dental hygiene ; Dentistry ; Development and progression ; Head and Neck Neoplasms - mortality ; Health aspects ; Humans ; Mouth ; Mouthwashes - therapeutic use ; Oral Hygiene ; Smoking ; Squamous cell carcinoma ; Survival Analysis</subject><ispartof>BMC oral health, 2016-03, Vol.16 (33), p.33-33, Article 33</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Friemel et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-bf7fa8bb529225d5bc9b31ffb6052b179d650e6550dcf5421f1be928c7ac6c463</citedby><cites>FETCH-LOGICAL-c494t-bf7fa8bb529225d5bc9b31ffb6052b179d650e6550dcf5421f1be928c7ac6c463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788953/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788953/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26969620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Friemel, Juliane</creatorcontrib><creatorcontrib>Foraita, Ronja</creatorcontrib><creatorcontrib>Günther, Kathrin</creatorcontrib><creatorcontrib>Heibeck, Mathias</creatorcontrib><creatorcontrib>Günther, Frauke</creatorcontrib><creatorcontrib>Pflueger, Maren</creatorcontrib><creatorcontrib>Pohlabeln, Hermann</creatorcontrib><creatorcontrib>Behrens, Thomas</creatorcontrib><creatorcontrib>Bullerdiek, Jörn</creatorcontrib><creatorcontrib>Nimzyk, Rolf</creatorcontrib><creatorcontrib>Ahrens, Wolfgang</creatorcontrib><title>Pretreatment oral hygiene habits and survival of head and neck squamous cell carcinoma (HNSCC) patients</title><title>BMC oral health</title><addtitle>BMC Oral Health</addtitle><description>The survival time of patients with head and neck squamous cell carcinoma (HNSCC) is related to health behavior, such as tobacco smoking and alcohol consumption. Poor oral health (OH), dental care (DC) and the frequent use of mouthwash have been shown to represent independent risk factors for head and neck cancerogenesis, but their impact on the survival of HNSCC patients has not been systematically investigated.
Two hundred seventy-six incident HNSCC cases recruited for the ARCAGE study were followed through a period of 6-10 years. Interview-based information on wearing of dentures, gum bleeding, teeth brushing, use of floss and dentist visits were grouped into weighted composite scores, i.e. oral health (OH) and dental care (DH). Use of mouthwash was assessed as frequency per day. Also obtained were other types of health behavior, such as smoking, alcohol drinking and diet, appreciated as both confounding and study variables. Endpoints were progression-free survival, overall survival and tumor-specific survival. Prognostic values were estimated using Kaplan-Meier analysis and Cox proportional hazards regression models.
A good dental care score, summarizing annual dental visits, daily teeth cleaning and use of floss was associated with longer overall survival time (p = .001). The results of the Cox regression models similarly suggested a higher risk of tumor progression and shortened overall survival in patients with poor dental care, but the results lost their statistical significance after other types of health behavior had been controlled for. Frequent use of mouthwash (≥ 2 times/day) significantly increased the risk of tumor-specific death (HR = 2.26; CI = 1.19-4.32). Alcohol consumption and tobacco smoking were dose-dependently associated with tumor progression and shorter overall survival.
Frequent mouthwash use of ≥ 2 times/day seems to elevate the risk of tumor-specific death in HNSCC patients. Good dental care scores are associated with longer overall survival.</description><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Dental care</subject><subject>Dental hygiene</subject><subject>Dentistry</subject><subject>Development and progression</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Mouth</subject><subject>Mouthwashes - therapeutic use</subject><subject>Oral Hygiene</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Survival Analysis</subject><issn>1472-6831</issn><issn>1472-6831</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUl1rFDEUDaLYWv0BvkjAl_owbZLJ17wIZVFbKFZQn0OSSXZTZ5JtMrPQf2_Grf0QuYSEe889955wAHiL0QnGkp8WTDrUNgjzeiRr0DNwiKkgDZctfv7ofQBelXKNEBaS0pfggPCuBkGHYP0tuyk7PY0uTjBlPcDN7Tq46OBGmzAVqGMPy5x3YVdrycON0_2fZHT2Fyw3sx7TXKB1wwCtzjbENGp4fP71-2r1AW71VMmm8hq88Hoo7s3dfQR-fv70Y3XeXF59uVidXTaWdnRqjBdeS2MY6QhhPTO2My323nDEiMGi6zlDjjOGeusZJdhj4zoirdCWW8rbI_Bxz7udzeh6W2dXTWqbw6jzrUo6qKeVGDZqnXaKCik71laC4zuCnG5mVyY1hrKI09FVnQoL0dIWcUIq9P0_0Os051jlVVQnJFuAD6i1HpwK0ac61y6k6ozWjRkXZNn75D-oGr0bg03R-VDzTxrwvsHmVEp2_l4jRmpxh9q7Q1V3qMUdalnl3ePPue_4a4f2N0BRtL4</recordid><startdate>20160311</startdate><enddate>20160311</enddate><creator>Friemel, Juliane</creator><creator>Foraita, Ronja</creator><creator>Günther, Kathrin</creator><creator>Heibeck, Mathias</creator><creator>Günther, Frauke</creator><creator>Pflueger, Maren</creator><creator>Pohlabeln, Hermann</creator><creator>Behrens, Thomas</creator><creator>Bullerdiek, Jörn</creator><creator>Nimzyk, Rolf</creator><creator>Ahrens, Wolfgang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160311</creationdate><title>Pretreatment oral hygiene habits and survival of head and neck squamous cell carcinoma (HNSCC) patients</title><author>Friemel, Juliane ; 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Poor oral health (OH), dental care (DC) and the frequent use of mouthwash have been shown to represent independent risk factors for head and neck cancerogenesis, but their impact on the survival of HNSCC patients has not been systematically investigated.
Two hundred seventy-six incident HNSCC cases recruited for the ARCAGE study were followed through a period of 6-10 years. Interview-based information on wearing of dentures, gum bleeding, teeth brushing, use of floss and dentist visits were grouped into weighted composite scores, i.e. oral health (OH) and dental care (DH). Use of mouthwash was assessed as frequency per day. Also obtained were other types of health behavior, such as smoking, alcohol drinking and diet, appreciated as both confounding and study variables. Endpoints were progression-free survival, overall survival and tumor-specific survival. Prognostic values were estimated using Kaplan-Meier analysis and Cox proportional hazards regression models.
A good dental care score, summarizing annual dental visits, daily teeth cleaning and use of floss was associated with longer overall survival time (p = .001). The results of the Cox regression models similarly suggested a higher risk of tumor progression and shortened overall survival in patients with poor dental care, but the results lost their statistical significance after other types of health behavior had been controlled for. Frequent use of mouthwash (≥ 2 times/day) significantly increased the risk of tumor-specific death (HR = 2.26; CI = 1.19-4.32). Alcohol consumption and tobacco smoking were dose-dependently associated with tumor progression and shorter overall survival.
Frequent mouthwash use of ≥ 2 times/day seems to elevate the risk of tumor-specific death in HNSCC patients. Good dental care scores are associated with longer overall survival.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26969620</pmid><doi>10.1186/s12903-016-0185-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC oral health, 2016-03, Vol.16 (33), p.33-33, Article 33 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; Springer Nature OA Free Journals; PubMed Central |
| subjects | Carcinoma, Squamous Cell - mortality Care and treatment Case-Control Studies Complications and side effects Dental care Dental hygiene Dentistry Development and progression Head and Neck Neoplasms - mortality Health aspects Humans Mouth Mouthwashes - therapeutic use Oral Hygiene Smoking Squamous cell carcinoma Survival Analysis |
| title | Pretreatment oral hygiene habits and survival of head and neck squamous cell carcinoma (HNSCC) patients |
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