Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which re...

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Veröffentlicht in:	BMC medical genetics 2016-03, Vol.17 (1), p.21-21, Article 21
Hauptverfasser:	Biswas, Nilima, Maihofer, Adam X, Mir, Saiful Anam, Rao, Fangwen, Zhang, Kuixing, Khandrika, Srikrishna, Mahata, Manjula, Friese, Ryan S, Hightower, C Makena, Mahata, Sushil K, Baker, Dewleen G, Nievergelt, Caroline M, Vaingankar, Sucheta M, O'Connor, Daniel T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alleles Analysis Angiotensin Angiotensin I - blood Angiotensinogen - blood Animals Blood Pressure Cardiovascular disease Cell Line Enzymes Ethnicity Factor XIIa - genetics Families & family life Family structure Gene Expression Regulation Genetic aspects Genetic Loci Genome-Wide Association Study Genomes Genotyping Techniques Humans Hypertension Hypertension - genetics Juxtaglomerular Apparatus - cytology Kallikrein Kallikreins - blood Kallikreins - genetics Male Mice Middle Aged Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Plasma Polymorphism, Single Nucleotide Post-traumatic stress disorder Prekallikrein - metabolism Renin - blood Renin - genetics Renin-angiotensin system Renin-Angiotensin System - genetics Serine Endopeptidases - metabolism Signal transduction Twins Young Adult
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