Target validation of highly conserved Amblyomma americanum tick saliva serine protease inhibitor 19

Amblyomma americanum tick serine protease inhibitor (serpin, AAS) 19, is a highly conserved protein that is characterized by its functional domain being 100% conserved across tick species. We also reported that AAS19 was an immunogenic tick saliva protein with anti-haemostatic functions and an inhib...

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Veröffentlicht in:	Ticks and tick-borne diseases 2016-04, Vol.7 (3), p.405-414
Hauptverfasser:	Kim, Tae K, Radulovic, Zeljko, Mulenga, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic - administration & dosage Amblyomma americanum Animals antibodies Antibodies, Neutralizing - biosynthesis Antibodies, Neutralizing - blood Arthropod Proteins - administration & dosage Arthropod Proteins - genetics Arthropod Proteins - immunology blood coagulation factors blood meal eggs Female Gene Expression immune response Immunogenicity, Vaccine messenger RNA Parasite Egg Count Pichia - genetics Pichia - metabolism Poloxalene - administration & dosage proteinase inhibitors Rabbits Recombinant Proteins - administration & dosage Recombinant Proteins - genetics Recombinant Proteins - immunology RNA interference RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics RNA, Messenger - immunology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism saliva Saliva - chemistry Saliva - immunology Serine Proteinase Inhibitors - administration & dosage Serine Proteinase Inhibitors - genetics Serine Proteinase Inhibitors - immunology serine proteinases tick infestations Tick Infestations - immunology Tick Infestations - parasitology Tick Infestations - prevention & control tick-borne diseases ticks Ticks - immunology vaccines Vaccines, Acellular - administration & dosage Vaccines, Acellular - genetics Vaccines, Acellular - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology
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