Long noncoding RNAs in innate immunity
Long noncoding RNAs （IncRNAs） have been shown to play important roles in immune cell development and immune responses through different mechanisms, such as dosage compensation, imprinting, enhancer function, and transcriptional regulation. Although the functions of most IncRNAs are unclear, some Inc...
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| Veröffentlicht in: | Cellular & molecular immunology 2016-03, Vol.13 (2), p.138-147 |
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| creator | Zhang, Yuan Cao, Xuetao |
| description | Long noncoding RNAs （IncRNAs） have been shown to play important roles in immune cell development and immune responses through different mechanisms, such as dosage compensation, imprinting, enhancer function, and transcriptional regulation. Although the functions of most IncRNAs are unclear, some IncRNAs have been found to control transcriptional or post-transcriptional regulation of the innate and adaptive immune responses via new methods of protein-protein interactions or pairing with DNA and RNA. Interestingly, increasing evidence has elucidated the importance of IncRNAs in the interaction between hosts and pathogens. In this review, an overview of the IncRNAs modes of action, as well as the important and diversified roles of IncRNAs in immunity, are provided, and an emerging paradigm of IncRNAs in regulating innate immune responses is highlighted. |
| doi_str_mv | 10.1038/cmi.2015.68 |
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Although the functions of most IncRNAs are unclear, some IncRNAs have been found to control transcriptional or post-transcriptional regulation of the innate and adaptive immune responses via new methods of protein-protein interactions or pairing with DNA and RNA. Interestingly, increasing evidence has elucidated the importance of IncRNAs in the interaction between hosts and pathogens. In this review, an overview of the IncRNAs modes of action, as well as the important and diversified roles of IncRNAs in immunity, are provided, and an emerging paradigm of IncRNAs in regulating innate immune responses is highlighted.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/cmi.2015.68</identifier><identifier>PMID: 26277893</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adaptive Immunity - physiology ; Animals ; Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Dosage compensation ; Dosage Compensation, Genetic - immunology ; Gene regulation ; Genomic Imprinting - immunology ; Humans ; Immune response ; Immunity, Innate - physiology ; Immunology ; Innate immunity ; Medical Microbiology ; Microbiology ; Non-coding RNA ; Post-transcription ; Protein interaction ; Review ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - immunology ; Transcription, Genetic - immunology ; Vaccine ; 先天免疫 ; 免疫反应 ; 免疫细胞 ; 剂量补偿 ; 蛋白质-蛋白质相互作用 ; 转录调控 ; 长链 ; 非编码RNA</subject><ispartof>Cellular & molecular immunology, 2016-03, Vol.13 (2), p.138-147</ispartof><rights>Chinese Society of Immunology and The University of Science and Technology 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Chinese Society of Immunology and The University of Science and Technology 2016.</rights><rights>Copyright © 2016 Chinese Society of Immunology and The University of Science and Technology 2016 Chinese Society of Immunology and The University of Science and Technology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-d00c5ac7478d26f304c8581ef86aa143529d8372be5dbd8239c5e61697c11de03</citedby><cites>FETCH-LOGICAL-c534t-d00c5ac7478d26f304c8581ef86aa143529d8372be5dbd8239c5e61697c11de03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/87787X/87787X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786632/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786632/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26277893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Cao, Xuetao</creatorcontrib><title>Long noncoding RNAs in innate immunity</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><description>Long noncoding RNAs （IncRNAs） have been shown to play important roles in immune cell development and immune responses through different mechanisms, such as dosage compensation, imprinting, enhancer function, and transcriptional regulation. 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Cao, Xuetao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-d00c5ac7478d26f304c8581ef86aa143529d8372be5dbd8239c5e61697c11de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adaptive Immunity - physiology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Dosage compensation</topic><topic>Dosage Compensation, Genetic - immunology</topic><topic>Gene regulation</topic><topic>Genomic Imprinting - immunology</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunity, Innate - physiology</topic><topic>Immunology</topic><topic>Innate immunity</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Non-coding RNA</topic><topic>Post-transcription</topic><topic>Protein interaction</topic><topic>Review</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - immunology</topic><topic>Transcription, Genetic - immunology</topic><topic>Vaccine</topic><topic>先天免疫</topic><topic>免疫反应</topic><topic>免疫细胞</topic><topic>剂量补偿</topic><topic>蛋白质-蛋白质相互作用</topic><topic>转录调控</topic><topic>长链</topic><topic>非编码RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Cao, Xuetao</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yuan</au><au>Cao, Xuetao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long noncoding RNAs in innate immunity</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>13</volume><issue>2</issue><spage>138</spage><epage>147</epage><pages>138-147</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>Long noncoding RNAs （IncRNAs） have been shown to play important roles in immune cell development and immune responses through different mechanisms, such as dosage compensation, imprinting, enhancer function, and transcriptional regulation. 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| subjects | Adaptive Immunity - physiology Animals Antibodies Biomedical and Life Sciences Biomedicine Dosage compensation Dosage Compensation, Genetic - immunology Gene regulation Genomic Imprinting - immunology Humans Immune response Immunity, Innate - physiology Immunology Innate immunity Medical Microbiology Microbiology Non-coding RNA Post-transcription Protein interaction Review RNA, Long Noncoding - genetics RNA, Long Noncoding - immunology Transcription, Genetic - immunology Vaccine 先天免疫 免疫反应 免疫细胞 剂量补偿 蛋白质-蛋白质相互作用 转录调控 长链 非编码RNA |
| title | Long noncoding RNAs in innate immunity |
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