Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia

Summary Streptococcus (S.) pneumoniae is the most common causative pathogen in community-acquired pneumonia. Coagulation and inflammation interact in the host response to infection. Tissue factor pathway inhibitor (TFPI) is a natural anticoagulant protein that inhibits tissue factor (TF), the main a...

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Veröffentlicht in:	Thrombosis and haemostasis 2015-07, Vol.113 (1), p.115-122
Hauptverfasser:	van den Boogaard, Florry E., van ’t Veer, Cornelis, Roelofs, Joris J. T. H., Meijers, Joost C. M., Schultz, Marcus J., Broze Jr, George, van der Poll, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Load Blood Cells, Inflammation and Infection Blood Coagulation Cytokines - blood Disease Models, Animal Genotype Host-Pathogen Interactions Humans Inflammation Mediators - blood Lipoproteins - blood Lipoproteins - deficiency Lipoproteins - genetics Lipoproteins - metabolism Lung - immunology Lung - metabolism Lung - microbiology Mice, Inbred C57BL Mice, Knockout Phenotype Pneumonia, Pneumococcal - blood Pneumonia, Pneumococcal - genetics Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - microbiology Streptococcus pneumoniae - growth & development Streptococcus pneumoniae - immunology Streptococcus pneumoniae - pathogenicity Time Factors
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