Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells
Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2016-03, Vol.6 (1), p.22850, Article 22850 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 22850 |
| container_title | Scientific reports |
| container_volume | 6 |
| creator | Mezzapelle, Rosanna Rrapaj, Eltjona Gatti, Elena Ceriotti, Chiara Marchis, Francesco De Preti, Alessandro Spinelli, Antonello E. Perani, Laura Venturini, Massimo Valtorta, Silvia Moresco, Rosa Maria Pecciarini, Lorenza Doglioni, Claudio Frenquelli, Michela Crippa, Luca Recordati, Camilla Scanziani, Eugenio de Vries, Hilda Berns, Anton Frapolli, Roberta Boldorini, Renzo D’Incalci, Maurizio Bianchi, Marco E. Crippa, Massimo P. |
| description | Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment. |
| doi_str_mv | 10.1038/srep22850 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4785401</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1898715419</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-157ea8461a1ef4bf30f0297f381a8ccebaac37e291fa2f13834552d958cb44bf3</originalsourceid><addsrcrecordid>eNplkc1KAzEUhYMoKurCF5CAK4Vqkkk6mY3QFv-g4EbXIU3vtCmTZExmFN_elGqpmE0C58u5h3sQOqfkhpJC3qYILWNSkD10zAgXA1Ywtr_zPkJnKa1IPoJVnFaH6IgNqyEtJTtGq6feaY-dbuzCa99hByl0S2hscBrbhCMY3dqub3QHc2w9ts71PpjgWuggfxiPpuNbg501kOUVmDX3absldn20HvBojA00TTpFB7VuEpz93Cfo7eH-dfI0mL48Pk9G04HhhewGVJSgJR9STaHms7ogNWFVWReSamkMzLQ2RQmsorVmNS1kwYVg80pIM-Nr_gTdbXzbfuZgbnLIqBvVRut0_FJBW_VX8XapFuFD8VIKTmg2uPwxiOG9h9SpVeijz5kVlZUsqchbzNTVhjIxpFxCvZ1AiVo3o7bNZPZiN9KW_O0hA9cbIGXJLyDujPzn9g0qhZm7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1898715419</pqid></control><display><type>article</type><title>Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Mezzapelle, Rosanna ; Rrapaj, Eltjona ; Gatti, Elena ; Ceriotti, Chiara ; Marchis, Francesco De ; Preti, Alessandro ; Spinelli, Antonello E. ; Perani, Laura ; Venturini, Massimo ; Valtorta, Silvia ; Moresco, Rosa Maria ; Pecciarini, Lorenza ; Doglioni, Claudio ; Frenquelli, Michela ; Crippa, Luca ; Recordati, Camilla ; Scanziani, Eugenio ; de Vries, Hilda ; Berns, Anton ; Frapolli, Roberta ; Boldorini, Renzo ; D’Incalci, Maurizio ; Bianchi, Marco E. ; Crippa, Massimo P.</creator><creatorcontrib>Mezzapelle, Rosanna ; Rrapaj, Eltjona ; Gatti, Elena ; Ceriotti, Chiara ; Marchis, Francesco De ; Preti, Alessandro ; Spinelli, Antonello E. ; Perani, Laura ; Venturini, Massimo ; Valtorta, Silvia ; Moresco, Rosa Maria ; Pecciarini, Lorenza ; Doglioni, Claudio ; Frenquelli, Michela ; Crippa, Luca ; Recordati, Camilla ; Scanziani, Eugenio ; de Vries, Hilda ; Berns, Anton ; Frapolli, Roberta ; Boldorini, Renzo ; D’Incalci, Maurizio ; Bianchi, Marco E. ; Crippa, Massimo P.</creatorcontrib><description>Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep22850</identifier><identifier>PMID: 26961782</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/106 ; 14/1 ; 14/28 ; 14/63 ; 38/1 ; 38/77 ; 49/23 ; 59/5 ; 59/78 ; 631/67/1641 ; 64/60 ; 692/4028/67/1641 ; 82/80 ; Animals ; Antineoplastic Agents - therapeutic use ; Cancer ; Cell Line, Tumor ; Cisplatin - therapeutic use ; Deoxycytidine - analogs & derivatives ; Deoxycytidine - therapeutic use ; Female ; High mobility group proteins ; HMGB1 Protein - metabolism ; Humanities and Social Sciences ; Humans ; Immune system ; Immunocompetence ; Inflammation ; Leukocytes ; Lung Neoplasms - blood supply ; Lung Neoplasms - drug therapy ; Lung Neoplasms - immunology ; Lung Neoplasms - pathology ; Mesothelioma ; Mesothelioma - blood supply ; Mesothelioma - drug therapy ; Mesothelioma - immunology ; Mesothelioma - pathology ; Mesothelioma, Malignant ; Mice, Inbred BALB C ; multidisciplinary ; Neoplasm Transplantation ; Pemetrexed - therapeutic use ; Rodents ; Science ; Science (multidisciplinary) ; Survival Analysis ; Tumor cells ; Tumors</subject><ispartof>Scientific reports, 2016-03, Vol.6 (1), p.22850, Article 22850</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-157ea8461a1ef4bf30f0297f381a8ccebaac37e291fa2f13834552d958cb44bf3</citedby><cites>FETCH-LOGICAL-c438t-157ea8461a1ef4bf30f0297f381a8ccebaac37e291fa2f13834552d958cb44bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785401/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785401/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26961782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mezzapelle, Rosanna</creatorcontrib><creatorcontrib>Rrapaj, Eltjona</creatorcontrib><creatorcontrib>Gatti, Elena</creatorcontrib><creatorcontrib>Ceriotti, Chiara</creatorcontrib><creatorcontrib>Marchis, Francesco De</creatorcontrib><creatorcontrib>Preti, Alessandro</creatorcontrib><creatorcontrib>Spinelli, Antonello E.</creatorcontrib><creatorcontrib>Perani, Laura</creatorcontrib><creatorcontrib>Venturini, Massimo</creatorcontrib><creatorcontrib>Valtorta, Silvia</creatorcontrib><creatorcontrib>Moresco, Rosa Maria</creatorcontrib><creatorcontrib>Pecciarini, Lorenza</creatorcontrib><creatorcontrib>Doglioni, Claudio</creatorcontrib><creatorcontrib>Frenquelli, Michela</creatorcontrib><creatorcontrib>Crippa, Luca</creatorcontrib><creatorcontrib>Recordati, Camilla</creatorcontrib><creatorcontrib>Scanziani, Eugenio</creatorcontrib><creatorcontrib>de Vries, Hilda</creatorcontrib><creatorcontrib>Berns, Anton</creatorcontrib><creatorcontrib>Frapolli, Roberta</creatorcontrib><creatorcontrib>Boldorini, Renzo</creatorcontrib><creatorcontrib>D’Incalci, Maurizio</creatorcontrib><creatorcontrib>Bianchi, Marco E.</creatorcontrib><creatorcontrib>Crippa, Massimo P.</creatorcontrib><title>Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.</description><subject>13/106</subject><subject>14/1</subject><subject>14/28</subject><subject>14/63</subject><subject>38/1</subject><subject>38/77</subject><subject>49/23</subject><subject>59/5</subject><subject>59/78</subject><subject>631/67/1641</subject><subject>64/60</subject><subject>692/4028/67/1641</subject><subject>82/80</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cisplatin - therapeutic use</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Deoxycytidine - therapeutic use</subject><subject>Female</subject><subject>High mobility group proteins</subject><subject>HMGB1 Protein - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunocompetence</subject><subject>Inflammation</subject><subject>Leukocytes</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - immunology</subject><subject>Lung Neoplasms - pathology</subject><subject>Mesothelioma</subject><subject>Mesothelioma - blood supply</subject><subject>Mesothelioma - drug therapy</subject><subject>Mesothelioma - immunology</subject><subject>Mesothelioma - pathology</subject><subject>Mesothelioma, Malignant</subject><subject>Mice, Inbred BALB C</subject><subject>multidisciplinary</subject><subject>Neoplasm Transplantation</subject><subject>Pemetrexed - therapeutic use</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Survival Analysis</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkc1KAzEUhYMoKurCF5CAK4Vqkkk6mY3QFv-g4EbXIU3vtCmTZExmFN_elGqpmE0C58u5h3sQOqfkhpJC3qYILWNSkD10zAgXA1Ywtr_zPkJnKa1IPoJVnFaH6IgNqyEtJTtGq6feaY-dbuzCa99hByl0S2hscBrbhCMY3dqub3QHc2w9ts71PpjgWuggfxiPpuNbg501kOUVmDX3absldn20HvBojA00TTpFB7VuEpz93Cfo7eH-dfI0mL48Pk9G04HhhewGVJSgJR9STaHms7ogNWFVWReSamkMzLQ2RQmsorVmNS1kwYVg80pIM-Nr_gTdbXzbfuZgbnLIqBvVRut0_FJBW_VX8XapFuFD8VIKTmg2uPwxiOG9h9SpVeijz5kVlZUsqchbzNTVhjIxpFxCvZ1AiVo3o7bNZPZiN9KW_O0hA9cbIGXJLyDujPzn9g0qhZm7</recordid><startdate>20160310</startdate><enddate>20160310</enddate><creator>Mezzapelle, Rosanna</creator><creator>Rrapaj, Eltjona</creator><creator>Gatti, Elena</creator><creator>Ceriotti, Chiara</creator><creator>Marchis, Francesco De</creator><creator>Preti, Alessandro</creator><creator>Spinelli, Antonello E.</creator><creator>Perani, Laura</creator><creator>Venturini, Massimo</creator><creator>Valtorta, Silvia</creator><creator>Moresco, Rosa Maria</creator><creator>Pecciarini, Lorenza</creator><creator>Doglioni, Claudio</creator><creator>Frenquelli, Michela</creator><creator>Crippa, Luca</creator><creator>Recordati, Camilla</creator><creator>Scanziani, Eugenio</creator><creator>de Vries, Hilda</creator><creator>Berns, Anton</creator><creator>Frapolli, Roberta</creator><creator>Boldorini, Renzo</creator><creator>D’Incalci, Maurizio</creator><creator>Bianchi, Marco E.</creator><creator>Crippa, Massimo P.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20160310</creationdate><title>Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells</title><author>Mezzapelle, Rosanna ; Rrapaj, Eltjona ; Gatti, Elena ; Ceriotti, Chiara ; Marchis, Francesco De ; Preti, Alessandro ; Spinelli, Antonello E. ; Perani, Laura ; Venturini, Massimo ; Valtorta, Silvia ; Moresco, Rosa Maria ; Pecciarini, Lorenza ; Doglioni, Claudio ; Frenquelli, Michela ; Crippa, Luca ; Recordati, Camilla ; Scanziani, Eugenio ; de Vries, Hilda ; Berns, Anton ; Frapolli, Roberta ; Boldorini, Renzo ; D’Incalci, Maurizio ; Bianchi, Marco E. ; Crippa, Massimo P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-157ea8461a1ef4bf30f0297f381a8ccebaac37e291fa2f13834552d958cb44bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>13/106</topic><topic>14/1</topic><topic>14/28</topic><topic>14/63</topic><topic>38/1</topic><topic>38/77</topic><topic>49/23</topic><topic>59/5</topic><topic>59/78</topic><topic>631/67/1641</topic><topic>64/60</topic><topic>692/4028/67/1641</topic><topic>82/80</topic><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cisplatin - therapeutic use</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Deoxycytidine - therapeutic use</topic><topic>Female</topic><topic>High mobility group proteins</topic><topic>HMGB1 Protein - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunocompetence</topic><topic>Inflammation</topic><topic>Leukocytes</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - immunology</topic><topic>Lung Neoplasms - pathology</topic><topic>Mesothelioma</topic><topic>Mesothelioma - blood supply</topic><topic>Mesothelioma - drug therapy</topic><topic>Mesothelioma - immunology</topic><topic>Mesothelioma - pathology</topic><topic>Mesothelioma, Malignant</topic><topic>Mice, Inbred BALB C</topic><topic>multidisciplinary</topic><topic>Neoplasm Transplantation</topic><topic>Pemetrexed - therapeutic use</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Survival Analysis</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mezzapelle, Rosanna</creatorcontrib><creatorcontrib>Rrapaj, Eltjona</creatorcontrib><creatorcontrib>Gatti, Elena</creatorcontrib><creatorcontrib>Ceriotti, Chiara</creatorcontrib><creatorcontrib>Marchis, Francesco De</creatorcontrib><creatorcontrib>Preti, Alessandro</creatorcontrib><creatorcontrib>Spinelli, Antonello E.</creatorcontrib><creatorcontrib>Perani, Laura</creatorcontrib><creatorcontrib>Venturini, Massimo</creatorcontrib><creatorcontrib>Valtorta, Silvia</creatorcontrib><creatorcontrib>Moresco, Rosa Maria</creatorcontrib><creatorcontrib>Pecciarini, Lorenza</creatorcontrib><creatorcontrib>Doglioni, Claudio</creatorcontrib><creatorcontrib>Frenquelli, Michela</creatorcontrib><creatorcontrib>Crippa, Luca</creatorcontrib><creatorcontrib>Recordati, Camilla</creatorcontrib><creatorcontrib>Scanziani, Eugenio</creatorcontrib><creatorcontrib>de Vries, Hilda</creatorcontrib><creatorcontrib>Berns, Anton</creatorcontrib><creatorcontrib>Frapolli, Roberta</creatorcontrib><creatorcontrib>Boldorini, Renzo</creatorcontrib><creatorcontrib>D’Incalci, Maurizio</creatorcontrib><creatorcontrib>Bianchi, Marco E.</creatorcontrib><creatorcontrib>Crippa, Massimo P.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mezzapelle, Rosanna</au><au>Rrapaj, Eltjona</au><au>Gatti, Elena</au><au>Ceriotti, Chiara</au><au>Marchis, Francesco De</au><au>Preti, Alessandro</au><au>Spinelli, Antonello E.</au><au>Perani, Laura</au><au>Venturini, Massimo</au><au>Valtorta, Silvia</au><au>Moresco, Rosa Maria</au><au>Pecciarini, Lorenza</au><au>Doglioni, Claudio</au><au>Frenquelli, Michela</au><au>Crippa, Luca</au><au>Recordati, Camilla</au><au>Scanziani, Eugenio</au><au>de Vries, Hilda</au><au>Berns, Anton</au><au>Frapolli, Roberta</au><au>Boldorini, Renzo</au><au>D’Incalci, Maurizio</au><au>Bianchi, Marco E.</au><au>Crippa, Massimo P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-03-10</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>22850</spage><pages>22850-</pages><artnum>22850</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26961782</pmid><doi>10.1038/srep22850</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2016-03, Vol.6 (1), p.22850, Article 22850 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4785401 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 13/106 14/1 14/28 14/63 38/1 38/77 49/23 59/5 59/78 631/67/1641 64/60 692/4028/67/1641 82/80 Animals Antineoplastic Agents - therapeutic use Cancer Cell Line, Tumor Cisplatin - therapeutic use Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Female High mobility group proteins HMGB1 Protein - metabolism Humanities and Social Sciences Humans Immune system Immunocompetence Inflammation Leukocytes Lung Neoplasms - blood supply Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - pathology Mesothelioma Mesothelioma - blood supply Mesothelioma - drug therapy Mesothelioma - immunology Mesothelioma - pathology Mesothelioma, Malignant Mice, Inbred BALB C multidisciplinary Neoplasm Transplantation Pemetrexed - therapeutic use Rodents Science Science (multidisciplinary) Survival Analysis Tumor cells Tumors |
| title | Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A15%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20malignant%20mesothelioma%20is%20recapitulated%20in%20immunocompetent%20BALB/c%20mice%20injected%20with%20murine%20AB%20cells&rft.jtitle=Scientific%20reports&rft.au=Mezzapelle,%20Rosanna&rft.date=2016-03-10&rft.volume=6&rft.issue=1&rft.spage=22850&rft.pages=22850-&rft.artnum=22850&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep22850&rft_dat=%3Cproquest_pubme%3E1898715419%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1898715419&rft_id=info:pmid/26961782&rfr_iscdi=true |