In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography
Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the v...
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| Veröffentlicht in: | Scientific reports 2016-03, Vol.6 (1), p.22792-22792, Article 22792 |
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| creator | Coughlan, Carolyn A. Chou, Li-dek Jing, Joseph C. Chen, Jason J. Rangarajan, Swathi Chang, Theodore H. Sharma, Giriraj K. Cho, Kyoungrai Lee, Donghoon Goddard, Julie A. Chen, Zhongping Wong, Brian J. F. |
| description | Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional video and Doppler analysis of their vocal fold motions during phonation. These vertical-cavity surface-emitting laser source (VCSEL) OCT images offer depth resolved, high-resolution, high-speed, and panoramic images of both the true and false vocal folds. This technology has the potential to revolutionize in-office imaging of the larynx. |
| doi_str_mv | 10.1038/srep22792 |
| format | Article |
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Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional video and Doppler analysis of their vocal fold motions during phonation. These vertical-cavity surface-emitting laser source (VCSEL) OCT images offer depth resolved, high-resolution, high-speed, and panoramic images of both the true and false vocal folds. This technology has the potential to revolutionize in-office imaging of the larynx.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep22792</identifier><identifier>PMID: 26960250</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 639/624/1075 ; 692/308/575 ; Anesthesia ; Biopsy ; Endoscopy ; Humanities and Social Sciences ; Humans ; Information processing ; Laryngoscopy - instrumentation ; Laryngoscopy - methods ; Larynx ; Lasers ; Lesions ; Medical imaging ; multidisciplinary ; Science ; Tomography ; Tomography, Optical Coherence - instrumentation ; Tomography, Optical Coherence - methods ; Vocal Cord Dysfunction - diagnostic imaging ; Vocal Cords - diagnostic imaging</subject><ispartof>Scientific reports, 2016-03, Vol.6 (1), p.22792-22792, Article 22792</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2ecdbdb5d258bb511e01e33bec74d868ca7a45b658f6ebae9db7cd9fed310763</citedby><cites>FETCH-LOGICAL-c438t-2ecdbdb5d258bb511e01e33bec74d868ca7a45b658f6ebae9db7cd9fed310763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785353/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785353/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26960250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coughlan, Carolyn A.</creatorcontrib><creatorcontrib>Chou, Li-dek</creatorcontrib><creatorcontrib>Jing, Joseph C.</creatorcontrib><creatorcontrib>Chen, Jason J.</creatorcontrib><creatorcontrib>Rangarajan, Swathi</creatorcontrib><creatorcontrib>Chang, Theodore H.</creatorcontrib><creatorcontrib>Sharma, Giriraj K.</creatorcontrib><creatorcontrib>Cho, Kyoungrai</creatorcontrib><creatorcontrib>Lee, Donghoon</creatorcontrib><creatorcontrib>Goddard, Julie A.</creatorcontrib><creatorcontrib>Chen, Zhongping</creatorcontrib><creatorcontrib>Wong, Brian J. F.</creatorcontrib><title>In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional video and Doppler analysis of their vocal fold motions during phonation. These vertical-cavity surface-emitting laser source (VCSEL) OCT images offer depth resolved, high-resolution, high-speed, and panoramic images of both the true and false vocal folds. This technology has the potential to revolutionize in-office imaging of the larynx.</description><subject>59</subject><subject>639/624/1075</subject><subject>692/308/575</subject><subject>Anesthesia</subject><subject>Biopsy</subject><subject>Endoscopy</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Information processing</subject><subject>Laryngoscopy - instrumentation</subject><subject>Laryngoscopy - methods</subject><subject>Larynx</subject><subject>Lasers</subject><subject>Lesions</subject><subject>Medical imaging</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - instrumentation</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Vocal Cord Dysfunction - diagnostic imaging</subject><subject>Vocal Cords - diagnostic imaging</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkUtr3DAUhUVoSUKaRf9AEHTTBNzoYdnyplDyaAMD2WQvJPn6EWzJkeyh8--jZKbDtNVG0r0fR1fnIPSZkm-UcHkdA0yMlRU7QqeM5CJjnLEPB-cTdB7jM0lLsCqn1TE6YUVVECbIKRofHF73a49t8DFmEezce6cH3I-67V2LfYPnDvDUper8Vhh02LjfeInvF-_aLGjXAr710zRAwH6ae5sErO8ggLOAZz_6Nuip23xCHxs9RDjf7Wfo6f7u6eZXtnr8-XDzY5XZnMs5Y2BrUxtRMyGNEZQCocC5AVvmtSyk1aXOhSmEbAowGqralLauGqg5JWXBz9D3rey0mBFqC24OelBTSJ8KG-V1r_7uuL5TrV-rvJSCC54Evu4Egn9ZIM5q7KOFYdAO_BIVLUsmOaUkT-iXf9Bnv4TkYKJkIiqZE5qoyy31bnOAZj8MJeotRrWPMbEXh9PvyT-hJeBqC8TUStaHgyf_U3sFlbCqMQ</recordid><startdate>20160310</startdate><enddate>20160310</enddate><creator>Coughlan, Carolyn A.</creator><creator>Chou, Li-dek</creator><creator>Jing, Joseph C.</creator><creator>Chen, Jason J.</creator><creator>Rangarajan, Swathi</creator><creator>Chang, Theodore H.</creator><creator>Sharma, Giriraj K.</creator><creator>Cho, Kyoungrai</creator><creator>Lee, Donghoon</creator><creator>Goddard, Julie A.</creator><creator>Chen, Zhongping</creator><creator>Wong, Brian J. 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F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-03-10</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>22792</spage><epage>22792</epage><pages>22792-22792</pages><artnum>22792</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients’ vocal folds as well as cross-sectional video and Doppler analysis of their vocal fold motions during phonation. These vertical-cavity surface-emitting laser source (VCSEL) OCT images offer depth resolved, high-resolution, high-speed, and panoramic images of both the true and false vocal folds. This technology has the potential to revolutionize in-office imaging of the larynx.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26960250</pmid><doi>10.1038/srep22792</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 59 639/624/1075 692/308/575 Anesthesia Biopsy Endoscopy Humanities and Social Sciences Humans Information processing Laryngoscopy - instrumentation Laryngoscopy - methods Larynx Lasers Lesions Medical imaging multidisciplinary Science Tomography Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - methods Vocal Cord Dysfunction - diagnostic imaging Vocal Cords - diagnostic imaging |
| title | In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography |
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