Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases
Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of t...
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| Veröffentlicht in: | BMC ophthalmology 2016-03, Vol.16 (26), p.26-26, Article 26 |
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| creator | Yamada, Hiroshi Yoneda, Masahiko Gosho, Masahiko Kato, Tomohiro Zako, Masahiro |
| description | Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of this study was to investigate differences in the expression profiles of MMPs and TIMPs induced by the prostaglandin analogs bimatoprost, latanoprost, and tafluprost in human non-pigmented ciliary epithelial cells (HNPCECs).
HNPCECs were cultured for 24 h with 0, 10, 100, or 1000 μM of the free acid forms of bimatoprost, latanoprost, and tafluprost. We measured the expression levels of MMPs and TIMPs using real-time polymerase chain reaction, and compared the results. Enzyme activities of MMP-2 and -9 in conditioned media were measured by gelatin zymography.
All prostaglandin analogs we examined dose-dependently increased expression levels of MMP-1, -2, -3, -9, and -17, whereas expression levels of TIMP-1 and -2 decreased with increasing concentrations of each analog. Each prostaglandin analog induced different levels of increases in MMPs and decreases in TIMPs.
Unique expression profiles of MMPs and TIMPs induced by bimatoprost, latanoprost, and tafluprost, as shown in HNPCECs, may contribute to clinically different effects on intraocular pressure decreases in patients with glaucoma or ocular hypertension. |
| doi_str_mv | 10.1186/s12886-016-0202-8 |
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HNPCECs were cultured for 24 h with 0, 10, 100, or 1000 μM of the free acid forms of bimatoprost, latanoprost, and tafluprost. We measured the expression levels of MMPs and TIMPs using real-time polymerase chain reaction, and compared the results. Enzyme activities of MMP-2 and -9 in conditioned media were measured by gelatin zymography.
All prostaglandin analogs we examined dose-dependently increased expression levels of MMP-1, -2, -3, -9, and -17, whereas expression levels of TIMP-1 and -2 decreased with increasing concentrations of each analog. Each prostaglandin analog induced different levels of increases in MMPs and decreases in TIMPs.
Unique expression profiles of MMPs and TIMPs induced by bimatoprost, latanoprost, and tafluprost, as shown in HNPCECs, may contribute to clinically different effects on intraocular pressure decreases in patients with glaucoma or ocular hypertension.</description><identifier>ISSN: 1471-2415</identifier><identifier>EISSN: 1471-2415</identifier><identifier>DOI: 10.1186/s12886-016-0202-8</identifier><identifier>PMID: 26956170</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Antihypertensive Agents - pharmacology ; Bimatoprost - pharmacology ; Care and treatment ; Cell Line ; Ciliary Body - drug effects ; Ciliary Body - metabolism ; Complications and side effects ; Dose-Response Relationship, Drug ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Gene Expression Regulation, Enzymologic - physiology ; Glaucoma ; Humans ; Hypertension ; Influence ; Matrix Metalloproteinases - genetics ; Metalloproteins ; Ophthalmology ; Prostaglandins F - pharmacology ; Prostaglandins F, Synthetic - pharmacology ; Real-Time Polymerase Chain Reaction ; Risk factors ; RNA, Messenger - genetics ; Tissue Inhibitor of Metalloproteinases - genetics</subject><ispartof>BMC ophthalmology, 2016-03, Vol.16 (26), p.26-26, Article 26</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Yamada et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-50f9947416ca1e8b566eb57f6248e87d6fde3b7fe75258898967e6514bd57f863</citedby><cites>FETCH-LOGICAL-c538t-50f9947416ca1e8b566eb57f6248e87d6fde3b7fe75258898967e6514bd57f863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784282/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784282/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26956170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Hiroshi</creatorcontrib><creatorcontrib>Yoneda, Masahiko</creatorcontrib><creatorcontrib>Gosho, Masahiko</creatorcontrib><creatorcontrib>Kato, Tomohiro</creatorcontrib><creatorcontrib>Zako, Masahiro</creatorcontrib><title>Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases</title><title>BMC ophthalmology</title><addtitle>BMC Ophthalmol</addtitle><description>Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of this study was to investigate differences in the expression profiles of MMPs and TIMPs induced by the prostaglandin analogs bimatoprost, latanoprost, and tafluprost in human non-pigmented ciliary epithelial cells (HNPCECs).
HNPCECs were cultured for 24 h with 0, 10, 100, or 1000 μM of the free acid forms of bimatoprost, latanoprost, and tafluprost. We measured the expression levels of MMPs and TIMPs using real-time polymerase chain reaction, and compared the results. Enzyme activities of MMP-2 and -9 in conditioned media were measured by gelatin zymography.
All prostaglandin analogs we examined dose-dependently increased expression levels of MMP-1, -2, -3, -9, and -17, whereas expression levels of TIMP-1 and -2 decreased with increasing concentrations of each analog. Each prostaglandin analog induced different levels of increases in MMPs and decreases in TIMPs.
Unique expression profiles of MMPs and TIMPs induced by bimatoprost, latanoprost, and tafluprost, as shown in HNPCECs, may contribute to clinically different effects on intraocular pressure decreases in patients with glaucoma or ocular hypertension.</description><subject>Antihypertensive Agents - pharmacology</subject><subject>Bimatoprost - pharmacology</subject><subject>Care and treatment</subject><subject>Cell Line</subject><subject>Ciliary Body - drug effects</subject><subject>Ciliary Body - metabolism</subject><subject>Complications and side effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - metabolism</subject><subject>Gene Expression Regulation, Enzymologic - physiology</subject><subject>Glaucoma</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Influence</subject><subject>Matrix Metalloproteinases - genetics</subject><subject>Metalloproteins</subject><subject>Ophthalmology</subject><subject>Prostaglandins F - pharmacology</subject><subject>Prostaglandins F, Synthetic - pharmacology</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Risk factors</subject><subject>RNA, Messenger - genetics</subject><subject>Tissue Inhibitor of Metalloproteinases - genetics</subject><issn>1471-2415</issn><issn>1471-2415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptks1OFjEUhidGI4hegBsziRsWDk47_ZuNCRAVEhI3um46M6dQ0mk_247Bq-CWOcMHCGqapn_v-zSnfavqLWkPCFHiYyZUKdG0BDttaaOeVbuESdJQRvjzR_Od6lXOly2KWKdeVjtU9FwQ2e5W10duNiVuUszlQ-1NMeF-YcJUF2P9cruuXZiWEerJWQsJQnHG13C1SZCzi6GOtkZQclf1DMV4v1IKuGAy5C3K5bwAYi7c4EpMt45_pK-rF9b4DG_uxr3qx5fP349PmrNvX0-PD8-akXeqNLy1fc8kI2I0BNTAhYCBSysoU6DkJOwE3SAtSE65Ur3qhQTBCRsmVCnR7VWfttzNMswwjVhQMl5vEj5H-q2jcfrpSXAX-jz-0kwqRhVFwP4dIMWfC-SiZ5dH8N4EiEvWREpKGBe0R-n7v6SXcUkBy0NVLxVvWd_9UZ0bD9oFG_HecYXqQ4ZFS8q7lXXwHxW2CWY3xgDW4f4TA9kaRvzFnMA-1EhavaZIb1OkMUV6TZFW6Hn3-HEeHPex6W4A2wPGDw</recordid><startdate>20160308</startdate><enddate>20160308</enddate><creator>Yamada, Hiroshi</creator><creator>Yoneda, Masahiko</creator><creator>Gosho, Masahiko</creator><creator>Kato, Tomohiro</creator><creator>Zako, Masahiro</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160308</creationdate><title>Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases</title><author>Yamada, Hiroshi ; Yoneda, Masahiko ; Gosho, Masahiko ; Kato, Tomohiro ; Zako, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-50f9947416ca1e8b566eb57f6248e87d6fde3b7fe75258898967e6514bd57f863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antihypertensive Agents - pharmacology</topic><topic>Bimatoprost - pharmacology</topic><topic>Care and treatment</topic><topic>Cell Line</topic><topic>Ciliary Body - drug effects</topic><topic>Ciliary Body - metabolism</topic><topic>Complications and side effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - metabolism</topic><topic>Gene Expression Regulation, Enzymologic - physiology</topic><topic>Glaucoma</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Influence</topic><topic>Matrix Metalloproteinases - genetics</topic><topic>Metalloproteins</topic><topic>Ophthalmology</topic><topic>Prostaglandins F - pharmacology</topic><topic>Prostaglandins F, Synthetic - pharmacology</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Risk factors</topic><topic>RNA, Messenger - genetics</topic><topic>Tissue Inhibitor of Metalloproteinases - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Hiroshi</creatorcontrib><creatorcontrib>Yoneda, Masahiko</creatorcontrib><creatorcontrib>Gosho, Masahiko</creatorcontrib><creatorcontrib>Kato, Tomohiro</creatorcontrib><creatorcontrib>Zako, Masahiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Hiroshi</au><au>Yoneda, Masahiko</au><au>Gosho, Masahiko</au><au>Kato, Tomohiro</au><au>Zako, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases</atitle><jtitle>BMC ophthalmology</jtitle><addtitle>BMC Ophthalmol</addtitle><date>2016-03-08</date><risdate>2016</risdate><volume>16</volume><issue>26</issue><spage>26</spage><epage>26</epage><pages>26-26</pages><artnum>26</artnum><issn>1471-2415</issn><eissn>1471-2415</eissn><abstract>Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of this study was to investigate differences in the expression profiles of MMPs and TIMPs induced by the prostaglandin analogs bimatoprost, latanoprost, and tafluprost in human non-pigmented ciliary epithelial cells (HNPCECs).
HNPCECs were cultured for 24 h with 0, 10, 100, or 1000 μM of the free acid forms of bimatoprost, latanoprost, and tafluprost. We measured the expression levels of MMPs and TIMPs using real-time polymerase chain reaction, and compared the results. Enzyme activities of MMP-2 and -9 in conditioned media were measured by gelatin zymography.
All prostaglandin analogs we examined dose-dependently increased expression levels of MMP-1, -2, -3, -9, and -17, whereas expression levels of TIMP-1 and -2 decreased with increasing concentrations of each analog. Each prostaglandin analog induced different levels of increases in MMPs and decreases in TIMPs.
Unique expression profiles of MMPs and TIMPs induced by bimatoprost, latanoprost, and tafluprost, as shown in HNPCECs, may contribute to clinically different effects on intraocular pressure decreases in patients with glaucoma or ocular hypertension.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26956170</pmid><doi>10.1186/s12886-016-0202-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antihypertensive Agents - pharmacology Bimatoprost - pharmacology Care and treatment Cell Line Ciliary Body - drug effects Ciliary Body - metabolism Complications and side effects Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation, Enzymologic - physiology Glaucoma Humans Hypertension Influence Matrix Metalloproteinases - genetics Metalloproteins Ophthalmology Prostaglandins F - pharmacology Prostaglandins F, Synthetic - pharmacology Real-Time Polymerase Chain Reaction Risk factors RNA, Messenger - genetics Tissue Inhibitor of Metalloproteinases - genetics |
| title | Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases |
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