Predicting the occurrence of major adverse cardiac events within 30 days of a vascular surgery: an empirical comparison of the minimum p value method and ROC curve approach using individual patient data meta-analysis

We aimed to compare the minimum p value method and the area under the receiver operating characteristics (ROC) curve approach to categorize continuous biomarkers for the prediction of postoperative 30-day major adverse cardiac events in noncardiac vascular surgery patients. Individual-patient data f...

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Veröffentlicht in:SpringerPlus 2016-03, Vol.5 (1), p.304-304, Article 304
Hauptverfasser: Vanniyasingam, Thuva, Rodseth, Reitze N., Lurati Buse, Giovanna A., Bolliger, Daniel, Burkhart, Christoph S., Cuthbertson, Brian H., Gibson, Simon C., Mahla, Elisabeth, Leibowitz, David W., Biccard, Bruce M., Thabane, Lehana
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Sprache:eng
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Zusammenfassung:We aimed to compare the minimum p value method and the area under the receiver operating characteristics (ROC) curve approach to categorize continuous biomarkers for the prediction of postoperative 30-day major adverse cardiac events in noncardiac vascular surgery patients. Individual-patient data from six cohorts reporting B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NTproBNP) were obtained. These biomarkers were dichotomized using the minimum p value method and compared with previously reported ROC curve-derived thresholds using logistic regression analysis. A final prediction model was developed, internally validated, and assessed for its sensitivity to clustering effects. Finally, a preoperative risk score system was proposed. Thresholds identified by the minimum p value method and ROC curve approach were 115.57 pg/ml (p 
ISSN:2193-1801
2193-1801
DOI:10.1186/s40064-016-1936-8