Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer

Highlights • TH+ nerves and NE turnover are demonstrated in murine mammary tumors. • TH+ nerves are restricted to the tumor periphery. • Sympathetic nerves are a major source of norepinephrine within mammary tumors. • Stressor exposure increased mammary tumor NE turnover. • Stressor exposure may reg...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-03, Vol.53, p.223-233
Hauptverfasser:	Szpunar, Mercedes J, Belcher, Elizabeth K, Dawes, Ryan P, Madden, Kelley S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Breast cancer Cell Line, Tumor Chemical sympathectomy Female Heterografts Humans Mammary Glands, Animal - innervation Mammary Neoplasms, Experimental - metabolism Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Norepinephrine Norepinephrine - metabolism Norepinephrine turnover Oxidopamine - pharmacology Psychiatry Spleen - metabolism Sympathetic nervous system Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Tyrosine 3-Monooxygenase - metabolism
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Beschreibung
Zusammenfassung:	Highlights • TH+ nerves and NE turnover are demonstrated in murine mammary tumors. • TH+ nerves are restricted to the tumor periphery. • Sympathetic nerves are a major source of norepinephrine within mammary tumors. • Stressor exposure increased mammary tumor NE turnover. • Stressor exposure may regulate mammary tumor progression by local NE release.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.12.014