Low level arsenic contaminated water consumption and birth outcomes in Romania—An exploratory study
•We prospectively followed 122 women with singleton live births residing in Romania.•We measured arsenic in drinking water and abstracted data from delivery records.•Women were exposed to low levels of drinking water arsenic, mostly
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2016-01, Vol.59, p.8-16 |
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| container_title | Reproductive toxicology (Elmsford, N.Y.) |
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| creator | Bloom, Michael S. Neamtiu, Iulia A. Surdu, Simona Pop, Cristian Anastasiu, Doru Appleton, Allison A. Fitzgerald, Edward F. Gurzau, Eugen S. |
| description | •We prospectively followed 122 women with singleton live births residing in Romania.•We measured arsenic in drinking water and abstracted data from delivery records.•Women were exposed to low levels of drinking water arsenic, mostly |
| doi_str_mv | 10.1016/j.reprotox.2015.10.012 |
| format | Article |
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Women are exposed to drinking water with low arsenic concentrations (<10.0μg/L) worldwide, yet little work has been done to assess the risk. To begin to address this data gap, we conducted an exploratory study of birth outcomes in Timis County, Romania. We prospectively followed 122 women with singleton deliveries, for whom we constructed individual exposure indicators using self-reported water consumption weighted by arsenic measured in drinking water sources. There were no overall confounder-adjusted effects for arsenic exposure on birth outcomes. Yet, higher average arsenic (10μg/L) was associated with a −2.45 lower birth weight Z-score (P=0.021) and a −1.17 shorter birth length Z-score (P=0.029) among smokers. Higher average iAs (10μg/L) was also associated with smaller ponderal index in boys (P=0.023). Our results suggest smoking may potentiate an otherwise benign arsenic exposure. A larger, more definitive biomarker-based study is needed to investigate the potential risks in conjunction with smoking.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2015.10.012</identifier><identifier>PMID: 26518419</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Arsenic ; Arsenic - adverse effects ; Arsenic - analysis ; Birth length ; Birth outcomes ; Birth size ; Birth Weight ; Body Size ; Case-Control Studies ; Drinking ; Drinking water ; Female ; Gestational Age ; Head - anatomy & histology ; Humans ; Logistic Models ; Maternal Exposure - adverse effects ; Multivariate Analysis ; Odds Ratio ; Ponderal index ; Pregnancy ; Pregnancy Outcome ; Proportional Hazards Models ; Prospective Studies ; Risk Assessment ; Risk Factors ; Romania ; Self Report ; Sex Factors ; Smoking - adverse effects ; Time Factors ; Water Pollutants, Chemical - adverse effects ; Water Pollutants, Chemical - analysis ; Water Supply ; Young Adult</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2016-01, Vol.59, p.8-16</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-67a01a53618a4240f56c5be7b8f5d7bf583d45516d695a9ce982587ec65abc4f3</citedby><cites>FETCH-LOGICAL-c504t-67a01a53618a4240f56c5be7b8f5d7bf583d45516d695a9ce982587ec65abc4f3</cites><orcidid>0000-0002-0028-5494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S089062381530037X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26518419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bloom, Michael S.</creatorcontrib><creatorcontrib>Neamtiu, Iulia A.</creatorcontrib><creatorcontrib>Surdu, Simona</creatorcontrib><creatorcontrib>Pop, Cristian</creatorcontrib><creatorcontrib>Anastasiu, Doru</creatorcontrib><creatorcontrib>Appleton, Allison A.</creatorcontrib><creatorcontrib>Fitzgerald, Edward F.</creatorcontrib><creatorcontrib>Gurzau, Eugen S.</creatorcontrib><title>Low level arsenic contaminated water consumption and birth outcomes in Romania—An exploratory study</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>•We prospectively followed 122 women with singleton live births residing in Romania.•We measured arsenic in drinking water and abstracted data from delivery records.•Women were exposed to low levels of drinking water arsenic, mostly <10μg/L.•Higher arsenic associated with lower birth weight and shorter length among smokers.•Higher arsenic was associated with lower ponderal index in boys only.
Women are exposed to drinking water with low arsenic concentrations (<10.0μg/L) worldwide, yet little work has been done to assess the risk. To begin to address this data gap, we conducted an exploratory study of birth outcomes in Timis County, Romania. We prospectively followed 122 women with singleton deliveries, for whom we constructed individual exposure indicators using self-reported water consumption weighted by arsenic measured in drinking water sources. There were no overall confounder-adjusted effects for arsenic exposure on birth outcomes. Yet, higher average arsenic (10μg/L) was associated with a −2.45 lower birth weight Z-score (P=0.021) and a −1.17 shorter birth length Z-score (P=0.029) among smokers. Higher average iAs (10μg/L) was also associated with smaller ponderal index in boys (P=0.023). Our results suggest smoking may potentiate an otherwise benign arsenic exposure. A larger, more definitive biomarker-based study is needed to investigate the potential risks in conjunction with smoking.</description><subject>Adult</subject><subject>Arsenic</subject><subject>Arsenic - adverse effects</subject><subject>Arsenic - analysis</subject><subject>Birth length</subject><subject>Birth outcomes</subject><subject>Birth size</subject><subject>Birth Weight</subject><subject>Body Size</subject><subject>Case-Control Studies</subject><subject>Drinking</subject><subject>Drinking water</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Head - anatomy & histology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Maternal Exposure - adverse effects</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Ponderal index</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Romania</subject><subject>Self Report</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><subject>Time Factors</subject><subject>Water Pollutants, Chemical - adverse effects</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Supply</subject><subject>Young Adult</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3DAUhUVpaaZJXyFo2Y2nkm39eFMaQvoDA4XQrIUsXTcabMmV5Elm14foE_ZJqmGS0K6ykeDo3HMu-hA6p2RNCeXvt-sIcww53K9rQlkR14TWL9CKStFUVBD5Eq2I7EjF60aeoDcpbQkhrejEa3RSc0ZlS7sVgk24wyPsYMQ6JvDOYBN81pPzOoPFd-WMBykt05xd8Fh7i3sX8y0OSzZhgoSdx9dh0t7pP79-X3gM9_MYos4h7nHKi92foVeDHhO8fbhP0c2nq--XX6rNt89fLy82lWGkzRUXmlDNGk6lbuuWDIwb1oPo5cCs6AcmG9syRrnlHdOdgU7WTAownOnetENzij4cc-eln8Aa8DnqUc3RTTruVdBO_f_i3a36EXaqFbKhkpSAdw8BMfxcIGU1uWRgHLWHsCRFhWhKZ1miWPnRamJIKcLwVEOJOjBSW_XISB0YHfTCqAye_7vk09gjlGL4eDRA-aqdg6iSceANWBfBZGWDe67jL53nqyA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Bloom, Michael S.</creator><creator>Neamtiu, Iulia A.</creator><creator>Surdu, Simona</creator><creator>Pop, Cristian</creator><creator>Anastasiu, Doru</creator><creator>Appleton, Allison A.</creator><creator>Fitzgerald, Edward F.</creator><creator>Gurzau, Eugen S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0028-5494</orcidid></search><sort><creationdate>20160101</creationdate><title>Low level arsenic contaminated water consumption and birth outcomes in Romania—An exploratory study</title><author>Bloom, Michael S. ; Neamtiu, Iulia A. ; Surdu, Simona ; Pop, Cristian ; Anastasiu, Doru ; Appleton, Allison A. ; Fitzgerald, Edward F. ; Gurzau, Eugen S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-67a01a53618a4240f56c5be7b8f5d7bf583d45516d695a9ce982587ec65abc4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Arsenic</topic><topic>Arsenic - adverse effects</topic><topic>Arsenic - analysis</topic><topic>Birth length</topic><topic>Birth outcomes</topic><topic>Birth size</topic><topic>Birth Weight</topic><topic>Body Size</topic><topic>Case-Control Studies</topic><topic>Drinking</topic><topic>Drinking water</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Head - anatomy & histology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Maternal Exposure - adverse effects</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Ponderal index</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Romania</topic><topic>Self Report</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><topic>Time Factors</topic><topic>Water Pollutants, Chemical - adverse effects</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Supply</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bloom, Michael S.</creatorcontrib><creatorcontrib>Neamtiu, Iulia A.</creatorcontrib><creatorcontrib>Surdu, Simona</creatorcontrib><creatorcontrib>Pop, Cristian</creatorcontrib><creatorcontrib>Anastasiu, Doru</creatorcontrib><creatorcontrib>Appleton, Allison A.</creatorcontrib><creatorcontrib>Fitzgerald, Edward F.</creatorcontrib><creatorcontrib>Gurzau, Eugen S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bloom, Michael S.</au><au>Neamtiu, Iulia A.</au><au>Surdu, Simona</au><au>Pop, Cristian</au><au>Anastasiu, Doru</au><au>Appleton, Allison A.</au><au>Fitzgerald, Edward F.</au><au>Gurzau, Eugen S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low level arsenic contaminated water consumption and birth outcomes in Romania—An exploratory study</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>59</volume><spage>8</spage><epage>16</epage><pages>8-16</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>•We prospectively followed 122 women with singleton live births residing in Romania.•We measured arsenic in drinking water and abstracted data from delivery records.•Women were exposed to low levels of drinking water arsenic, mostly <10μg/L.•Higher arsenic associated with lower birth weight and shorter length among smokers.•Higher arsenic was associated with lower ponderal index in boys only.
Women are exposed to drinking water with low arsenic concentrations (<10.0μg/L) worldwide, yet little work has been done to assess the risk. To begin to address this data gap, we conducted an exploratory study of birth outcomes in Timis County, Romania. We prospectively followed 122 women with singleton deliveries, for whom we constructed individual exposure indicators using self-reported water consumption weighted by arsenic measured in drinking water sources. There were no overall confounder-adjusted effects for arsenic exposure on birth outcomes. Yet, higher average arsenic (10μg/L) was associated with a −2.45 lower birth weight Z-score (P=0.021) and a −1.17 shorter birth length Z-score (P=0.029) among smokers. Higher average iAs (10μg/L) was also associated with smaller ponderal index in boys (P=0.023). Our results suggest smoking may potentiate an otherwise benign arsenic exposure. A larger, more definitive biomarker-based study is needed to investigate the potential risks in conjunction with smoking.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26518419</pmid><doi>10.1016/j.reprotox.2015.10.012</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0028-5494</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2016-01, Vol.59, p.8-16 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Arsenic Arsenic - adverse effects Arsenic - analysis Birth length Birth outcomes Birth size Birth Weight Body Size Case-Control Studies Drinking Drinking water Female Gestational Age Head - anatomy & histology Humans Logistic Models Maternal Exposure - adverse effects Multivariate Analysis Odds Ratio Ponderal index Pregnancy Pregnancy Outcome Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Romania Self Report Sex Factors Smoking - adverse effects Time Factors Water Pollutants, Chemical - adverse effects Water Pollutants, Chemical - analysis Water Supply Young Adult |
| title | Low level arsenic contaminated water consumption and birth outcomes in Romania—An exploratory study |
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