Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats
The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy in young rats. Six-week-old male Sprague-Dawley rats maintained on a low salt diet were given CsA (15 mg/kg), CsA and LSR...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2016-03, Vol.6 (1), p.22374, Article 22374 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 22374 |
| container_title | Scientific reports |
| container_volume | 6 |
| creator | Kim, Ji Hong Lee, Yeon Hee Lim, Beom Jin Jeong, Hyeon Joo Kim, Pyung Kil Shin, Jae Il |
| description | The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy in young rats. Six-week-old male Sprague-Dawley rats maintained on a low salt diet were given CsA (15 mg/kg), CsA and LSRT (30 mg/kg/day), CsA and MZR (5 mg/kg), or a combination of CsA, LSRT, and MZR for 4 and 7 weeks (two experiments) and compared with control group (olive oil-treated). Histopathology and glomerular size, inflammatory and fibrotic factors were studied. The score of acute CsA toxicity significantly decreased in the CsA + MZR group compared to the CsA group (p |
| doi_str_mv | 10.1038/srep22374 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4780085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1898715948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-cf43ec9954ad0ab08262ddf6826bed1124d6104837e1a1055cecfc99c0a19b3b3</originalsourceid><addsrcrecordid>eNplkc1KxDAUhYMoKqMLX0ACrhRGkzT92wgy-AeCG12HNL3pVDpJTVJ1fAFf25TRYcRsbuB-55wLB6EjSs4pSYoL76BnLMn5FtpnhKdTljC2vfHfQ4fev5D4UlZyWu6iPZaVPM8zvo--7o3uBjAKsNVYLVVnfW9dawBfYWtw09kFuKGTDjfOvoc5lqbGYQ4YtAYVRtWi_YyKatSMy-ggXZBmlP8xNNDPnQ32o1VtWOLW4KUdTIOdDP4A7WjZeTj8mRP0fHP9NLubPjze3s-uHqaKJ0WYKs0TUGWZclkTWZGCZayudRZnBTWljNcZJbxIcqCSkjRVoHTkFZG0rJIqmaDLlW8_VAuoFZjgZCd61y6kWworW_F3Y9q5aOyb4HlBSJFGg5MfA2dfB_BBvNjBmXizoEVZ5DQtY_wEna4o5ayPDel1AiVirE2sa4vs8eZJa_K3pAicrQAfV6YBtxH5z-0bQcKlwQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1898715948</pqid></control><display><type>article</type><title>Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Kim, Ji Hong ; Lee, Yeon Hee ; Lim, Beom Jin ; Jeong, Hyeon Joo ; Kim, Pyung Kil ; Shin, Jae Il</creator><creatorcontrib>Kim, Ji Hong ; Lee, Yeon Hee ; Lim, Beom Jin ; Jeong, Hyeon Joo ; Kim, Pyung Kil ; Shin, Jae Il</creatorcontrib><description>The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy in young rats. Six-week-old male Sprague-Dawley rats maintained on a low salt diet were given CsA (15 mg/kg), CsA and LSRT (30 mg/kg/day), CsA and MZR (5 mg/kg), or a combination of CsA, LSRT, and MZR for 4 and 7 weeks (two experiments) and compared with control group (olive oil-treated). Histopathology and glomerular size, inflammatory and fibrotic factors were studied. The score of acute CsA toxicity significantly decreased in the CsA + MZR group compared to the CsA group (p < 0.01). MZR and MZR + LSRT reduced tubulointerstitial fibrosis and TGF-β1 mRNA expression at 7 weeks. Osteopontin (OPN) mRNA expression was decreased at 7 weeks in MZR + LSRT (p < 0.01). Glomerular area decreased CsA group and recovered in MZR (p < 0.01) and MZR + LSRT (p < 0.01) at 7weeks. This study demonstrated that MZR and LSRT had suppressive effects on inflammatory process in chronic CsA nephropathy and led to improvement of tubular damage, tubulointerstitial fibrosis and arteriolopathy by down regulation of OPN and TGF-β1 and glomerular size contraction.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep22374</identifier><identifier>PMID: 26947764</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/272/1684/1587 ; 692/4022/1585/2760/267 ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - metabolism ; Contraction ; Cyclosporine - toxicity ; Cyclosporins ; Fibrosis ; Gene expression ; Histocytochemistry ; Histopathology ; Humanities and Social Sciences ; Inflammation ; Kidney - pathology ; Kidney Diseases - chemically induced ; Kidney Diseases - prevention & control ; Kidney Glomerulus - drug effects ; Losartan - metabolism ; Male ; multidisciplinary ; Nephropathy ; Olive oil ; Osteopontin ; Rats, Sprague-Dawley ; Ribonucleosides - metabolism ; Rodents ; Science ; Science (multidisciplinary) ; Toxicity ; Transforming growth factor-b1</subject><ispartof>Scientific reports, 2016-03, Vol.6 (1), p.22374, Article 22374</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-cf43ec9954ad0ab08262ddf6826bed1124d6104837e1a1055cecfc99c0a19b3b3</citedby><cites>FETCH-LOGICAL-c438t-cf43ec9954ad0ab08262ddf6826bed1124d6104837e1a1055cecfc99c0a19b3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780085/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780085/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26947764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ji Hong</creatorcontrib><creatorcontrib>Lee, Yeon Hee</creatorcontrib><creatorcontrib>Lim, Beom Jin</creatorcontrib><creatorcontrib>Jeong, Hyeon Joo</creatorcontrib><creatorcontrib>Kim, Pyung Kil</creatorcontrib><creatorcontrib>Shin, Jae Il</creatorcontrib><title>Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy in young rats. Six-week-old male Sprague-Dawley rats maintained on a low salt diet were given CsA (15 mg/kg), CsA and LSRT (30 mg/kg/day), CsA and MZR (5 mg/kg), or a combination of CsA, LSRT, and MZR for 4 and 7 weeks (two experiments) and compared with control group (olive oil-treated). Histopathology and glomerular size, inflammatory and fibrotic factors were studied. The score of acute CsA toxicity significantly decreased in the CsA + MZR group compared to the CsA group (p < 0.01). MZR and MZR + LSRT reduced tubulointerstitial fibrosis and TGF-β1 mRNA expression at 7 weeks. Osteopontin (OPN) mRNA expression was decreased at 7 weeks in MZR + LSRT (p < 0.01). Glomerular area decreased CsA group and recovered in MZR (p < 0.01) and MZR + LSRT (p < 0.01) at 7weeks. This study demonstrated that MZR and LSRT had suppressive effects on inflammatory process in chronic CsA nephropathy and led to improvement of tubular damage, tubulointerstitial fibrosis and arteriolopathy by down regulation of OPN and TGF-β1 and glomerular size contraction.</description><subject>631/443/272/1684/1587</subject><subject>692/4022/1585/2760/267</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - metabolism</subject><subject>Contraction</subject><subject>Cyclosporine - toxicity</subject><subject>Cyclosporins</subject><subject>Fibrosis</subject><subject>Gene expression</subject><subject>Histocytochemistry</subject><subject>Histopathology</subject><subject>Humanities and Social Sciences</subject><subject>Inflammation</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - prevention & control</subject><subject>Kidney Glomerulus - drug effects</subject><subject>Losartan - metabolism</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Nephropathy</subject><subject>Olive oil</subject><subject>Osteopontin</subject><subject>Rats, Sprague-Dawley</subject><subject>Ribonucleosides - metabolism</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Toxicity</subject><subject>Transforming growth factor-b1</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkc1KxDAUhYMoKqMLX0ACrhRGkzT92wgy-AeCG12HNL3pVDpJTVJ1fAFf25TRYcRsbuB-55wLB6EjSs4pSYoL76BnLMn5FtpnhKdTljC2vfHfQ4fev5D4UlZyWu6iPZaVPM8zvo--7o3uBjAKsNVYLVVnfW9dawBfYWtw09kFuKGTDjfOvoc5lqbGYQ4YtAYVRtWi_YyKatSMy-ggXZBmlP8xNNDPnQ32o1VtWOLW4KUdTIOdDP4A7WjZeTj8mRP0fHP9NLubPjze3s-uHqaKJ0WYKs0TUGWZclkTWZGCZayudRZnBTWljNcZJbxIcqCSkjRVoHTkFZG0rJIqmaDLlW8_VAuoFZjgZCd61y6kWworW_F3Y9q5aOyb4HlBSJFGg5MfA2dfB_BBvNjBmXizoEVZ5DQtY_wEna4o5ayPDel1AiVirE2sa4vs8eZJa_K3pAicrQAfV6YBtxH5z-0bQcKlwQ</recordid><startdate>20160307</startdate><enddate>20160307</enddate><creator>Kim, Ji Hong</creator><creator>Lee, Yeon Hee</creator><creator>Lim, Beom Jin</creator><creator>Jeong, Hyeon Joo</creator><creator>Kim, Pyung Kil</creator><creator>Shin, Jae Il</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20160307</creationdate><title>Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats</title><author>Kim, Ji Hong ; Lee, Yeon Hee ; Lim, Beom Jin ; Jeong, Hyeon Joo ; Kim, Pyung Kil ; Shin, Jae Il</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-cf43ec9954ad0ab08262ddf6826bed1124d6104837e1a1055cecfc99c0a19b3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/443/272/1684/1587</topic><topic>692/4022/1585/2760/267</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - metabolism</topic><topic>Contraction</topic><topic>Cyclosporine - toxicity</topic><topic>Cyclosporins</topic><topic>Fibrosis</topic><topic>Gene expression</topic><topic>Histocytochemistry</topic><topic>Histopathology</topic><topic>Humanities and Social Sciences</topic><topic>Inflammation</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - prevention & control</topic><topic>Kidney Glomerulus - drug effects</topic><topic>Losartan - metabolism</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Nephropathy</topic><topic>Olive oil</topic><topic>Osteopontin</topic><topic>Rats, Sprague-Dawley</topic><topic>Ribonucleosides - metabolism</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Toxicity</topic><topic>Transforming growth factor-b1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ji Hong</creatorcontrib><creatorcontrib>Lee, Yeon Hee</creatorcontrib><creatorcontrib>Lim, Beom Jin</creatorcontrib><creatorcontrib>Jeong, Hyeon Joo</creatorcontrib><creatorcontrib>Kim, Pyung Kil</creatorcontrib><creatorcontrib>Shin, Jae Il</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ji Hong</au><au>Lee, Yeon Hee</au><au>Lim, Beom Jin</au><au>Jeong, Hyeon Joo</au><au>Kim, Pyung Kil</au><au>Shin, Jae Il</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-03-07</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>22374</spage><pages>22374-</pages><artnum>22374</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy in young rats. Six-week-old male Sprague-Dawley rats maintained on a low salt diet were given CsA (15 mg/kg), CsA and LSRT (30 mg/kg/day), CsA and MZR (5 mg/kg), or a combination of CsA, LSRT, and MZR for 4 and 7 weeks (two experiments) and compared with control group (olive oil-treated). Histopathology and glomerular size, inflammatory and fibrotic factors were studied. The score of acute CsA toxicity significantly decreased in the CsA + MZR group compared to the CsA group (p < 0.01). MZR and MZR + LSRT reduced tubulointerstitial fibrosis and TGF-β1 mRNA expression at 7 weeks. Osteopontin (OPN) mRNA expression was decreased at 7 weeks in MZR + LSRT (p < 0.01). Glomerular area decreased CsA group and recovered in MZR (p < 0.01) and MZR + LSRT (p < 0.01) at 7weeks. This study demonstrated that MZR and LSRT had suppressive effects on inflammatory process in chronic CsA nephropathy and led to improvement of tubular damage, tubulointerstitial fibrosis and arteriolopathy by down regulation of OPN and TGF-β1 and glomerular size contraction.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26947764</pmid><doi>10.1038/srep22374</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2016-03, Vol.6 (1), p.22374, Article 22374 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4780085 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/443/272/1684/1587 692/4022/1585/2760/267 Animals Anti-Inflammatory Agents, Non-Steroidal - metabolism Contraction Cyclosporine - toxicity Cyclosporins Fibrosis Gene expression Histocytochemistry Histopathology Humanities and Social Sciences Inflammation Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - prevention & control Kidney Glomerulus - drug effects Losartan - metabolism Male multidisciplinary Nephropathy Olive oil Osteopontin Rats, Sprague-Dawley Ribonucleosides - metabolism Rodents Science Science (multidisciplinary) Toxicity Transforming growth factor-b1 |
| title | Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T18%3A29%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20cyclosporine%20A%20on%20glomerular%20growth%20and%20the%20effect%20of%20mizoribine%20and%20losartan%20on%20cyclosporine%20nephrotoxicity%20in%20young%20rats&rft.jtitle=Scientific%20reports&rft.au=Kim,%20Ji%20Hong&rft.date=2016-03-07&rft.volume=6&rft.issue=1&rft.spage=22374&rft.pages=22374-&rft.artnum=22374&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep22374&rft_dat=%3Cproquest_pubme%3E1898715948%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1898715948&rft_id=info:pmid/26947764&rfr_iscdi=true |