Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions

Previous studies suggested that an amorphous solid dispersion with a copolymer consisting of both hydrophobic and hydrophilic monomers could improve the dissolution profile of a poorly water-soluble drug compared to the crystalline form. Therefore, this study investigated the influence of the copoly...

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Veröffentlicht in:	The AAPS journal 2016-03, Vol.18 (2), p.416-423
Hauptverfasser:	Knopp, Matthias Manne, Nguyen, Julia Hoang, Mu, Huiling, Langguth, Peter, Rades, Thomas, Holm, René
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Celecoxib - blood Celecoxib - chemistry Chemistry, Pharmaceutical Male Pharmacology/Toxicology Pharmacy Polymers - chemistry Polymers - metabolism Povidone - chemistry Povidone - metabolism Rats Rats, Sprague-Dawley Research Article Solubility Vinyl Compounds - blood Vinyl Compounds - chemistry X-Ray Diffraction
Online-Zugang:	Volltext
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