MULTIDRUG-RESISTANT ENTEROCOCCUS FAECIUM MENINGITIS IN A TODDLER: CHARACTERIZATION OF THE ORGANISM AND SUCCESSFUL TREATMENT WITH INTRAVENTRICULAR DAPTOMYCIN AND INTRAVENOUS TIGECYCLINE

A case of enterococcal meningitis in a toddler is presented. The organism was highly resistant to all drugs previously used for pediatric Gram-positive meningitis. She was successfully treated with intraventricular and intravenous daptomycin and intravenous tigecycline. The organism was characterize...

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Veröffentlicht in:	The Pediatric infectious disease journal 2010-04, Vol.29 (4), p.379-381
Hauptverfasser:	JASPAN, Heather B, BROTHERS, Adam W, CAMPBELL, Angela J. P, MCGUIRE, John K, BROWD, Samuel R, MANLEY, Thomas J, PAK, Daniel, WEISSMAN, Scott J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Daptomycin - administration & dosage Daptomycin - therapeutic use Drug Resistance, Multiple, Bacterial Enterococcus faecium - classification Enterococcus faecium - drug effects Enterococcus faecium - isolation & purification Female Humans Infant Infectious diseases Injections, Intravenous Injections, Intraventricular Medical sciences Meningitis, Bacterial - drug therapy Meningitis, Bacterial - microbiology Minocycline - administration & dosage Minocycline - analogs & derivatives Minocycline - therapeutic use Pharmacology. Drug treatments Treatment Outcome Vancomycin Resistance
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Zusammenfassung:	A case of enterococcal meningitis in a toddler is presented. The organism was highly resistant to all drugs previously used for pediatric Gram-positive meningitis. She was successfully treated with intraventricular and intravenous daptomycin and intravenous tigecycline. The organism was characterized as a member of CC17, a notorious emerging nosocomial clone of Enterococcus faecium.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e3181c806d8