Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards
The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and com...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical semantics 2016-03, Vol.7 (10), p.10-10, Article 10 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | 10 |
| container_start_page | 10 |
| container_title | Journal of biomedical semantics |
| container_volume | 7 |
| creator | Jiang, Guoqian Evans, Julie Endle, Cory M Solbrig, Harold R Chute, Christopher G |
| description | The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development.
We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates.
A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6).
Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research. |
| doi_str_mv | 10.1186/s13326-016-0053-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4778326</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A445049172</galeid><sourcerecordid>A445049172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-4474f6bac13fa722992a3557e4f923828f7a3e7b7a01cefc340497de1519b8ed3</originalsourceid><addsrcrecordid>eNptkl9r1jAUxosobsx9AG8k4I03nUmTNumNMIabwsALHV6G0_Skb0ab1CQVBn548_LOuYkJIf9-z0nO4amq14yeMaa694lx3nQ1ZWXQltfts-q4oYLVTCj6_NH6qDpN6ZaWxjmjir-sjpquF31L1XH16yY5P5GvuIDPzpDvOJCMZufDHCaHidgQSd4hmdBjhOyCJ8GSMSzgfJ1WNM4WWcZlnSEXPgeStnUNMRMzO-8MzCTlbbwjC2YYIUPZgh8hjulV9cLCnPD0fj6pbi4_frv4VF9_ufp8cX5dG9GLXAshhe0GMIxbkE3T9w3wtpUobN9w1SgrgaMcJFBm0BouqOjliKxl_aBw5CfVh0PcdRsWHA36HGHWa3QLxDsdwOmnN97t9BR-aiGlKkUuAd7dB4jhx4Yp68Ulg_MMHsOWNJOSCaFYqwr69h_0NmzRl_QK1bd9pxrO_1ITzKidt6G8a_ZB9bkQbfk_k02hzv5DlT7i4kzwaF05fyJgB4GJIaWI9iFHRvXeNfrgGl1co_eu0W3RvHlcnAfFH4_w39Prvhg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1795968233</pqid></control><display><type>article</type><title>Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SpringerNature Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Jiang, Guoqian ; Evans, Julie ; Endle, Cory M ; Solbrig, Harold R ; Chute, Christopher G</creator><creatorcontrib>Jiang, Guoqian ; Evans, Julie ; Endle, Cory M ; Solbrig, Harold R ; Chute, Christopher G</creatorcontrib><description>The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development.
We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates.
A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6).
Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.</description><identifier>ISSN: 2041-1480</identifier><identifier>EISSN: 2041-1480</identifier><identifier>DOI: 10.1186/s13326-016-0053-5</identifier><identifier>PMID: 26949508</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Biomedical Research ; Clinical trials ; Collaboration ; Consortia ; Data exchange ; Data models ; Digital libraries ; Electronic health records ; Health care ; Human subjects ; Humans ; Initiatives ; Internet ; Interoperability ; Laboratories ; Library collections ; Life sciences ; Medical Informatics - methods ; Medical Informatics - standards ; Metadata ; Models, Theoretical ; Ontology ; Reference Standards ; Regulatory agencies ; Resource Description Framework-RDF ; Semantic web ; Semantics ; Statistical analysis ; Web Ontology Language-OWL ; World Wide Web</subject><ispartof>Journal of biomedical semantics, 2016-03, Vol.7 (10), p.10-10, Article 10</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Jiang et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-4474f6bac13fa722992a3557e4f923828f7a3e7b7a01cefc340497de1519b8ed3</citedby><cites>FETCH-LOGICAL-c494t-4474f6bac13fa722992a3557e4f923828f7a3e7b7a01cefc340497de1519b8ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778326/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778326/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26949508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Guoqian</creatorcontrib><creatorcontrib>Evans, Julie</creatorcontrib><creatorcontrib>Endle, Cory M</creatorcontrib><creatorcontrib>Solbrig, Harold R</creatorcontrib><creatorcontrib>Chute, Christopher G</creatorcontrib><title>Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards</title><title>Journal of biomedical semantics</title><addtitle>J Biomed Semantics</addtitle><description>The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development.
We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates.
A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6).
Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.</description><subject>Biomedical Research</subject><subject>Clinical trials</subject><subject>Collaboration</subject><subject>Consortia</subject><subject>Data exchange</subject><subject>Data models</subject><subject>Digital libraries</subject><subject>Electronic health records</subject><subject>Health care</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Initiatives</subject><subject>Internet</subject><subject>Interoperability</subject><subject>Laboratories</subject><subject>Library collections</subject><subject>Life sciences</subject><subject>Medical Informatics - methods</subject><subject>Medical Informatics - standards</subject><subject>Metadata</subject><subject>Models, Theoretical</subject><subject>Ontology</subject><subject>Reference Standards</subject><subject>Regulatory agencies</subject><subject>Resource Description Framework-RDF</subject><subject>Semantic web</subject><subject>Semantics</subject><subject>Statistical analysis</subject><subject>Web Ontology Language-OWL</subject><subject>World Wide Web</subject><issn>2041-1480</issn><issn>2041-1480</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkl9r1jAUxosobsx9AG8k4I03nUmTNumNMIabwsALHV6G0_Skb0ab1CQVBn548_LOuYkJIf9-z0nO4amq14yeMaa694lx3nQ1ZWXQltfts-q4oYLVTCj6_NH6qDpN6ZaWxjmjir-sjpquF31L1XH16yY5P5GvuIDPzpDvOJCMZufDHCaHidgQSd4hmdBjhOyCJ8GSMSzgfJ1WNM4WWcZlnSEXPgeStnUNMRMzO-8MzCTlbbwjC2YYIUPZgh8hjulV9cLCnPD0fj6pbi4_frv4VF9_ufp8cX5dG9GLXAshhe0GMIxbkE3T9w3wtpUobN9w1SgrgaMcJFBm0BouqOjliKxl_aBw5CfVh0PcdRsWHA36HGHWa3QLxDsdwOmnN97t9BR-aiGlKkUuAd7dB4jhx4Yp68Ulg_MMHsOWNJOSCaFYqwr69h_0NmzRl_QK1bd9pxrO_1ITzKidt6G8a_ZB9bkQbfk_k02hzv5DlT7i4kzwaF05fyJgB4GJIaWI9iFHRvXeNfrgGl1co_eu0W3RvHlcnAfFH4_w39Prvhg</recordid><startdate>20160303</startdate><enddate>20160303</enddate><creator>Jiang, Guoqian</creator><creator>Evans, Julie</creator><creator>Endle, Cory M</creator><creator>Solbrig, Harold R</creator><creator>Chute, Christopher G</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160303</creationdate><title>Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards</title><author>Jiang, Guoqian ; Evans, Julie ; Endle, Cory M ; Solbrig, Harold R ; Chute, Christopher G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-4474f6bac13fa722992a3557e4f923828f7a3e7b7a01cefc340497de1519b8ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomedical Research</topic><topic>Clinical trials</topic><topic>Collaboration</topic><topic>Consortia</topic><topic>Data exchange</topic><topic>Data models</topic><topic>Digital libraries</topic><topic>Electronic health records</topic><topic>Health care</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Initiatives</topic><topic>Internet</topic><topic>Interoperability</topic><topic>Laboratories</topic><topic>Library collections</topic><topic>Life sciences</topic><topic>Medical Informatics - methods</topic><topic>Medical Informatics - standards</topic><topic>Metadata</topic><topic>Models, Theoretical</topic><topic>Ontology</topic><topic>Reference Standards</topic><topic>Regulatory agencies</topic><topic>Resource Description Framework-RDF</topic><topic>Semantic web</topic><topic>Semantics</topic><topic>Statistical analysis</topic><topic>Web Ontology Language-OWL</topic><topic>World Wide Web</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Guoqian</creatorcontrib><creatorcontrib>Evans, Julie</creatorcontrib><creatorcontrib>Endle, Cory M</creatorcontrib><creatorcontrib>Solbrig, Harold R</creatorcontrib><creatorcontrib>Chute, Christopher G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical semantics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Guoqian</au><au>Evans, Julie</au><au>Endle, Cory M</au><au>Solbrig, Harold R</au><au>Chute, Christopher G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards</atitle><jtitle>Journal of biomedical semantics</jtitle><addtitle>J Biomed Semantics</addtitle><date>2016-03-03</date><risdate>2016</risdate><volume>7</volume><issue>10</issue><spage>10</spage><epage>10</epage><pages>10-10</pages><artnum>10</artnum><issn>2041-1480</issn><eissn>2041-1480</eissn><abstract>The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development.
We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates.
A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6).
Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26949508</pmid><doi>10.1186/s13326-016-0053-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2041-1480 |
| ispartof | Journal of biomedical semantics, 2016-03, Vol.7 (10), p.10-10, Article 10 |
| issn | 2041-1480 2041-1480 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4778326 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biomedical Research Clinical trials Collaboration Consortia Data exchange Data models Digital libraries Electronic health records Health care Human subjects Humans Initiatives Internet Interoperability Laboratories Library collections Life sciences Medical Informatics - methods Medical Informatics - standards Metadata Models, Theoretical Ontology Reference Standards Regulatory agencies Resource Description Framework-RDF Semantic web Semantics Statistical analysis Web Ontology Language-OWL World Wide Web |
| title | Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A48%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Using%20Semantic%20Web%20technologies%20for%20the%20generation%20of%20domain-specific%20templates%20to%20support%20clinical%20study%20metadata%20standards&rft.jtitle=Journal%20of%20biomedical%20semantics&rft.au=Jiang,%20Guoqian&rft.date=2016-03-03&rft.volume=7&rft.issue=10&rft.spage=10&rft.epage=10&rft.pages=10-10&rft.artnum=10&rft.issn=2041-1480&rft.eissn=2041-1480&rft_id=info:doi/10.1186/s13326-016-0053-5&rft_dat=%3Cgale_pubme%3EA445049172%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1795968233&rft_id=info:pmid/26949508&rft_galeid=A445049172&rfr_iscdi=true |