CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10
The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPC...
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| Veröffentlicht in: | Scientific reports 2016-03, Vol.6 (1), p.22649-22649, Article 22649 |
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| creator | Hessner, F. Dlugos, C. P. Chehab, T. Schaefer, C. Homey, B. Gerke, V. Weide, T. Pavenstädt, H. Rescher, U. |
| description | The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca
2+
binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention. |
| doi_str_mv | 10.1038/srep22649 |
| format | Article |
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2+
binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep22649</identifier><identifier>PMID: 26941067</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/19 ; 631/1647/245/2225 ; 631/45/612/194 ; 82/80 ; 96/106 ; 96/109 ; 96/31 ; Annexin A2 - metabolism ; Calcium ; Calcium-binding protein ; Cell Line, Tumor ; Cell surface ; Chemokines ; G protein-coupled receptors ; Gene Expression Regulation ; Humanities and Social Sciences ; Humans ; Immune response ; Melanocytes ; Melanocytes - metabolism ; Membrane Proteins - metabolism ; multidisciplinary ; Protein Binding ; Protein Interaction Mapping ; Receptors, CCR10 - metabolism ; S100 protein ; S100 Proteins - metabolism ; Science ; Science (multidisciplinary) ; Tumors</subject><ispartof>Scientific reports, 2016-03, Vol.6 (1), p.22649-22649, Article 22649</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-65917f1296b856ec2a88f9d8e9b47a22aa349b2282ecc8710dc67e3c902deee23</citedby><cites>FETCH-LOGICAL-c438t-65917f1296b856ec2a88f9d8e9b47a22aa349b2282ecc8710dc67e3c902deee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778132/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778132/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26941067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hessner, F.</creatorcontrib><creatorcontrib>Dlugos, C. P.</creatorcontrib><creatorcontrib>Chehab, T.</creatorcontrib><creatorcontrib>Schaefer, C.</creatorcontrib><creatorcontrib>Homey, B.</creatorcontrib><creatorcontrib>Gerke, V.</creatorcontrib><creatorcontrib>Weide, T.</creatorcontrib><creatorcontrib>Pavenstädt, H.</creatorcontrib><creatorcontrib>Rescher, U.</creatorcontrib><title>CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca
2+
binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.</description><subject>14/19</subject><subject>631/1647/245/2225</subject><subject>631/45/612/194</subject><subject>82/80</subject><subject>96/106</subject><subject>96/109</subject><subject>96/31</subject><subject>Annexin A2 - metabolism</subject><subject>Calcium</subject><subject>Calcium-binding protein</subject><subject>Cell Line, Tumor</subject><subject>Cell surface</subject><subject>Chemokines</subject><subject>G protein-coupled receptors</subject><subject>Gene Expression Regulation</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune response</subject><subject>Melanocytes</subject><subject>Melanocytes - metabolism</subject><subject>Membrane Proteins - metabolism</subject><subject>multidisciplinary</subject><subject>Protein Binding</subject><subject>Protein Interaction Mapping</subject><subject>Receptors, CCR10 - metabolism</subject><subject>S100 protein</subject><subject>S100 Proteins - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tumors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkUFv1DAQhS0EolXpgT-ALHEBpAV74sT2BalatYBUiQNwthxnspuS2MF2ivbf42XLagFfPNJ88_zGj5DnnL3lrFLvUsQZoBH6ETkHJuoVVACPT-ozcpnSHSunBi24fkrOoCkFa-Q5-bleU7fFKXwfPNKIDuccIuWMOhxHmpbYW4d0jpjQZ5uH4Ong6YSj9cHtMiY6pDK3WUabsaPtjuYtUh_ucSxgxmjd76HZxuwx0i-csSvOnpEnvR0TXj7cF-TbzfXX9cfV7ecPn9ZXtysnKpVXTa257DnoplV1gw6sUr3uFOpWSAtgbSV0C6AAnVOSs841EiunGXSICNUFeX_QnZd2ws6VJaIdzRyHycadCXYwf3f8sDWbcG-ElIpXe4FXDwIx_FgwZTMNaf831mNYkuFSMiUFr0RBX_6D3oUl-rKe4UoXd7VkslCvD5SLIZXw-qMZzsw-UXNMtLAvTt0fyT_5FeDNAUil5TcYT578T-0XSJarIA</recordid><startdate>20160304</startdate><enddate>20160304</enddate><creator>Hessner, F.</creator><creator>Dlugos, C. 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P.</creatorcontrib><creatorcontrib>Chehab, T.</creatorcontrib><creatorcontrib>Schaefer, C.</creatorcontrib><creatorcontrib>Homey, B.</creatorcontrib><creatorcontrib>Gerke, V.</creatorcontrib><creatorcontrib>Weide, T.</creatorcontrib><creatorcontrib>Pavenstädt, H.</creatorcontrib><creatorcontrib>Rescher, U.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hessner, F.</au><au>Dlugos, C. P.</au><au>Chehab, T.</au><au>Schaefer, C.</au><au>Homey, B.</au><au>Gerke, V.</au><au>Weide, T.</au><au>Pavenstädt, H.</au><au>Rescher, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-03-04</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>22649</spage><epage>22649</epage><pages>22649-22649</pages><artnum>22649</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca
2+
binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26941067</pmid><doi>10.1038/srep22649</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 14/19 631/1647/245/2225 631/45/612/194 82/80 96/106 96/109 96/31 Annexin A2 - metabolism Calcium Calcium-binding protein Cell Line, Tumor Cell surface Chemokines G protein-coupled receptors Gene Expression Regulation Humanities and Social Sciences Humans Immune response Melanocytes Melanocytes - metabolism Membrane Proteins - metabolism multidisciplinary Protein Binding Protein Interaction Mapping Receptors, CCR10 - metabolism S100 protein S100 Proteins - metabolism Science Science (multidisciplinary) Tumors |
| title | CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10 |
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