HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution
The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of HoxD genes, as well as the cluster-associated genes Evx2 and LNP , in the paddlefi...
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| Veröffentlicht in: | Scientific reports 2016-03, Vol.6 (1), p.22720-22720, Article 22720 |
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| creator | Tulenko, Frank J. Augustus, Gaius J. Massey, James L. Sims, Seth E. Mazan, Sylvie Davis, Marcus C. |
| description | The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of
HoxD
genes, as well as the cluster-associated genes
Evx2
and
LNP
, in the paddlefish
Polyodon spathula
, a basal ray-finned fish. Our results demonstrate a collinear pattern of nesting in early fin buds that includes
HoxD14
, a gene previously thought to be isolated from global
Hox
regulation. We also show that in both
Polyodon
and the catshark
Scyliorhinus canicula
(a representative chondrichthyan) late phase
HoxD
transcripts are present in cells of the fin-fold and co-localize with
And1
, a component of the dermal skeleton. These new data support an ancestral role for
HoxD
genes in patterning the fin-folds of jawed vertebrates, and fuel new hypotheses about the evolution of cluster regulation and the potential downstream differentiation outcomes of distinct
HoxD
-regulated compartments. |
| doi_str_mv | 10.1038/srep22720 |
| format | Article |
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HoxD
genes, as well as the cluster-associated genes
Evx2
and
LNP
, in the paddlefish
Polyodon spathula
, a basal ray-finned fish. Our results demonstrate a collinear pattern of nesting in early fin buds that includes
HoxD14
, a gene previously thought to be isolated from global
Hox
regulation. We also show that in both
Polyodon
and the catshark
Scyliorhinus canicula
(a representative chondrichthyan) late phase
HoxD
transcripts are present in cells of the fin-fold and co-localize with
And1
, a component of the dermal skeleton. These new data support an ancestral role for
HoxD
genes in patterning the fin-folds of jawed vertebrates, and fuel new hypotheses about the evolution of cluster regulation and the potential downstream differentiation outcomes of distinct
HoxD
-regulated compartments.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep22720</identifier><identifier>PMID: 26940624</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/63 ; 38 ; 38/23 ; 38/77 ; 631/136/756 ; 631/181/2806 ; Animal Fins - embryology ; Animals ; Buds ; Earth Sciences ; Evolution ; Fishes - embryology ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genes ; Homeobox ; Homeodomain Proteins - biosynthesis ; Humanities and Social Sciences ; Life Sciences ; multidisciplinary ; Nesting ; Oceanography ; Science ; Science (multidisciplinary) ; Sciences of the Universe ; Sequence Analysis, DNA ; Skin ; Transcription factors</subject><ispartof>Scientific reports, 2016-03, Vol.6 (1), p.22720-22720, Article 22720</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Attribution</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-6aacbd5a66253147068ae9101d1035fbf67bee9dc490f91d0d0c59952d0b46113</citedby><cites>FETCH-LOGICAL-c538t-6aacbd5a66253147068ae9101d1035fbf67bee9dc490f91d0d0c59952d0b46113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778128/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778128/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26940624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-01285085$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tulenko, Frank J.</creatorcontrib><creatorcontrib>Augustus, Gaius J.</creatorcontrib><creatorcontrib>Massey, James L.</creatorcontrib><creatorcontrib>Sims, Seth E.</creatorcontrib><creatorcontrib>Mazan, Sylvie</creatorcontrib><creatorcontrib>Davis, Marcus C.</creatorcontrib><title>HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of
HoxD
genes, as well as the cluster-associated genes
Evx2
and
LNP
, in the paddlefish
Polyodon spathula
, a basal ray-finned fish. Our results demonstrate a collinear pattern of nesting in early fin buds that includes
HoxD14
, a gene previously thought to be isolated from global
Hox
regulation. We also show that in both
Polyodon
and the catshark
Scyliorhinus canicula
(a representative chondrichthyan) late phase
HoxD
transcripts are present in cells of the fin-fold and co-localize with
And1
, a component of the dermal skeleton. These new data support an ancestral role for
HoxD
genes in patterning the fin-folds of jawed vertebrates, and fuel new hypotheses about the evolution of cluster regulation and the potential downstream differentiation outcomes of distinct
HoxD
-regulated compartments.</description><subject>14/63</subject><subject>38</subject><subject>38/23</subject><subject>38/77</subject><subject>631/136/756</subject><subject>631/181/2806</subject><subject>Animal Fins - embryology</subject><subject>Animals</subject><subject>Buds</subject><subject>Earth Sciences</subject><subject>Evolution</subject><subject>Fishes - embryology</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Homeobox</subject><subject>Homeodomain Proteins - biosynthesis</subject><subject>Humanities and Social Sciences</subject><subject>Life Sciences</subject><subject>multidisciplinary</subject><subject>Nesting</subject><subject>Oceanography</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sciences of the Universe</subject><subject>Sequence Analysis, DNA</subject><subject>Skin</subject><subject>Transcription factors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkVFvFCEUhYnR2Kb2wT9gSHxRk1FgYAZeTJqqXZNNfNFnwgyXXZoZmMLMpv572Wxdt5UXyL0f53A5CL2m5CMltfyUE0yMtYw8Q-eMcFGxmrHnJ-czdJnzLSlLMMWpeonOWKM4aRg_R3ereP8Fw_2UIGcfA_YBz1vAzofKxcHiPo6TSfMIYcbR4c5kM-BNMPM25jmOkLEJFvtxGnxv5qKQsYsJT8YnsNhMEwRrNoBhF4dl33-FXjgzZLh82C_Qr29ff16vqvWPm-_XV-uqF7Wcq8aYvrPCNA0TNeUtaaQBRQm1ZWrhOte0HYCyPVfEKWqJJb1QSjBLOt5QWl-gzwfdaelGsH0ZIJlBT8mPJv3W0Xj9uBP8Vm_iTvO2lZTJIvD-ILB9cm11tdb7GimUIFLs9mbvHsxSvFsgz3r0uYdhMAHikjVtWyJbTqko6Nsn6G1cUihfoalUsqVCSPbPvE8xl4jd8QWU6H3u-ph7Yd-cTnok_6ZcgA8HIJdW2EA6sfxP7Q-xo7f0</recordid><startdate>20160304</startdate><enddate>20160304</enddate><creator>Tulenko, Frank J.</creator><creator>Augustus, Gaius J.</creator><creator>Massey, James L.</creator><creator>Sims, Seth E.</creator><creator>Mazan, Sylvie</creator><creator>Davis, Marcus C.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope></search><sort><creationdate>20160304</creationdate><title>HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution</title><author>Tulenko, Frank J. ; Augustus, Gaius J. ; Massey, James L. ; Sims, Seth E. ; Mazan, Sylvie ; Davis, Marcus C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-6aacbd5a66253147068ae9101d1035fbf67bee9dc490f91d0d0c59952d0b46113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>14/63</topic><topic>38</topic><topic>38/23</topic><topic>38/77</topic><topic>631/136/756</topic><topic>631/181/2806</topic><topic>Animal Fins - embryology</topic><topic>Animals</topic><topic>Buds</topic><topic>Earth Sciences</topic><topic>Evolution</topic><topic>Fishes - embryology</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Homeobox</topic><topic>Homeodomain Proteins - biosynthesis</topic><topic>Humanities and Social Sciences</topic><topic>Life Sciences</topic><topic>multidisciplinary</topic><topic>Nesting</topic><topic>Oceanography</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sciences of the Universe</topic><topic>Sequence Analysis, DNA</topic><topic>Skin</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tulenko, Frank J.</creatorcontrib><creatorcontrib>Augustus, Gaius J.</creatorcontrib><creatorcontrib>Massey, James L.</creatorcontrib><creatorcontrib>Sims, Seth E.</creatorcontrib><creatorcontrib>Mazan, Sylvie</creatorcontrib><creatorcontrib>Davis, Marcus C.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tulenko, Frank J.</au><au>Augustus, Gaius J.</au><au>Massey, James L.</au><au>Sims, Seth E.</au><au>Mazan, Sylvie</au><au>Davis, Marcus C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-03-04</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>22720</spage><epage>22720</epage><pages>22720-22720</pages><artnum>22720</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of
HoxD
genes, as well as the cluster-associated genes
Evx2
and
LNP
, in the paddlefish
Polyodon spathula
, a basal ray-finned fish. Our results demonstrate a collinear pattern of nesting in early fin buds that includes
HoxD14
, a gene previously thought to be isolated from global
Hox
regulation. We also show that in both
Polyodon
and the catshark
Scyliorhinus canicula
(a representative chondrichthyan) late phase
HoxD
transcripts are present in cells of the fin-fold and co-localize with
And1
, a component of the dermal skeleton. These new data support an ancestral role for
HoxD
genes in patterning the fin-folds of jawed vertebrates, and fuel new hypotheses about the evolution of cluster regulation and the potential downstream differentiation outcomes of distinct
HoxD
-regulated compartments.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26940624</pmid><doi>10.1038/srep22720</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 14/63 38 38/23 38/77 631/136/756 631/181/2806 Animal Fins - embryology Animals Buds Earth Sciences Evolution Fishes - embryology Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Genes Homeobox Homeodomain Proteins - biosynthesis Humanities and Social Sciences Life Sciences multidisciplinary Nesting Oceanography Science Science (multidisciplinary) Sciences of the Universe Sequence Analysis, DNA Skin Transcription factors |
| title | HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution |
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