Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

Exosomes are small extracellular vesicles released by cells and play important roles in intercellular communication and pathogen transfer. Exosomes have been implicated in several neurodegenerative diseases, including prion disease and Alzheimer disease. Prion disease arises upon misfolding of the n...

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Veröffentlicht in:	The Journal of biological chemistry 2016-03, Vol.291 (10), p.5128-5137
Hauptverfasser:	Guo, Belinda B., Bellingham, Shayne A., Hill, Andrew F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Animals Benzylidene Compounds - pharmacology cell biology Cell Line Cell Membrane - drug effects Cell Membrane - metabolism exosome (vesicle) exosomes Exosomes - drug effects Exosomes - metabolism extracellular vesicles Mice Molecular Bases of Disease monensin Monensin - pharmacology neutral sphingomy neutral sphingomyelinase prion prion disease Prions - chemistry Prions - metabolism Protein Stability Protein Transport Rabbits transwell
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