Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches

Purpose This study tested the hypothesis that encapsulation of influenza vaccine in microneedle patches increases vaccine stability during storage at elevated temperature. Methods Whole inactivated influenza virus vaccine (A/Puerto Rico/8/34) was formulated into dissolving microneedle patches and va...

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Veröffentlicht in:	Pharmaceutical research 2016-04, Vol.33 (4), p.868-878
Hauptverfasser:	Chu, Leonard Y., Ye, Ling, Dong, Ke, Compans, Richard W., Yang, Chinglai, Prausnitz, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Drug Delivery Systems Drug Storage Enzyme-linked immunosorbent assay Hot Temperature Humans Immunization Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza Vaccines - therapeutic use Influenza virus Influenza viruses Influenza, Human - immunology Influenza, Human - prevention & control Medical Law Mice Needles Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pharmacology Pharmacology/Toxicology Pharmacy Research Paper Transdermal Patch Vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Vaccines, Inactivated - therapeutic use
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