A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery
In this single-center trial comparing chlorhexidine–alcohol with iodine–alcohol for skin antisepsis before cesarean delivery, the use of chlorhexidine–alcohol resulted in a risk of surgical-site infection that was significantly lower than that associated with iodine–alcohol. Cesarean delivery is the...
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| Veröffentlicht in: | The New England journal of medicine 2016-02, Vol.374 (7), p.647-55 |
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| container_title | The New England journal of medicine |
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| creator | Tuuli, Methodius G Liu, Jingxia Stout, Molly J Martin, Shannon Cahill, Alison G Odibo, Anthony O Colditz, Graham A Macones, George A |
| description | In this single-center trial comparing chlorhexidine–alcohol with iodine–alcohol for skin antisepsis before cesarean delivery, the use of chlorhexidine–alcohol resulted in a risk of surgical-site infection that was significantly lower than that associated with iodine–alcohol.
Cesarean delivery is the most common major surgical procedure among women in the United States.
1
In 2013, more than 32.7% (1.3 million) of the 3.9 million births were by cesarean section.
2
Surgical-site infections complicate 2 to 5% of all surgical procedures and 5 to 12% of cesarean deliveries.
3
–
6
Infection occurring after delivery places an extra burden on the new mother and may impair mother–infant bonding and breast-feeding. The average attributable hospital cost per surgical-site infection after cesarean delivery is estimated to be $3,529.
7
The skin is a major source of pathogens that cause surgical-site infections. Therefore, preoperative skin antisepsis . . . |
| doi_str_mv | 10.1056/NEJMoa1511048 |
| format | Article |
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Cesarean delivery is the most common major surgical procedure among women in the United States.
1
In 2013, more than 32.7% (1.3 million) of the 3.9 million births were by cesarean section.
2
Surgical-site infections complicate 2 to 5% of all surgical procedures and 5 to 12% of cesarean deliveries.
3
–
6
Infection occurring after delivery places an extra burden on the new mother and may impair mother–infant bonding and breast-feeding. The average attributable hospital cost per surgical-site infection after cesarean delivery is estimated to be $3,529.
7
The skin is a major source of pathogens that cause surgical-site infections. Therefore, preoperative skin antisepsis . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1511048</identifier><identifier>PMID: 26844840</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Anti-Infective Agents, Local - adverse effects ; Anti-Infective Agents, Local - therapeutic use ; Antimicrobial agents ; Antisepsis - methods ; Cesarean Section ; Chlorhexidine ; Chlorhexidine - adverse effects ; Chlorhexidine - therapeutic use ; Clinical trials ; Evidence-based medicine ; Female ; Humans ; Infections ; Iodine ; Iodine - adverse effects ; Iodine - therapeutic use ; Motivation ; Pathogens ; Pregnancy ; Prevention ; Skin ; Skin - drug effects ; Surgical site infections ; Surgical Wound Infection - prevention & control</subject><ispartof>The New England journal of medicine, 2016-02, Vol.374 (7), p.647-55</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-c7d9cb2ac4c799d03b8f37e8a7d542cc7767e579017925bd30f78114cf95ce563</citedby><cites>FETCH-LOGICAL-c511t-c7d9cb2ac4c799d03b8f37e8a7d542cc7767e579017925bd30f78114cf95ce563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1511048$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1511048$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26844840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuuli, Methodius G</creatorcontrib><creatorcontrib>Liu, Jingxia</creatorcontrib><creatorcontrib>Stout, Molly J</creatorcontrib><creatorcontrib>Martin, Shannon</creatorcontrib><creatorcontrib>Cahill, Alison G</creatorcontrib><creatorcontrib>Odibo, Anthony O</creatorcontrib><creatorcontrib>Colditz, Graham A</creatorcontrib><creatorcontrib>Macones, George A</creatorcontrib><title>A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this single-center trial comparing chlorhexidine–alcohol with iodine–alcohol for skin antisepsis before cesarean delivery, the use of chlorhexidine–alcohol resulted in a risk of surgical-site infection that was significantly lower than that associated with iodine–alcohol.
Cesarean delivery is the most common major surgical procedure among women in the United States.
1
In 2013, more than 32.7% (1.3 million) of the 3.9 million births were by cesarean section.
2
Surgical-site infections complicate 2 to 5% of all surgical procedures and 5 to 12% of cesarean deliveries.
3
–
6
Infection occurring after delivery places an extra burden on the new mother and may impair mother–infant bonding and breast-feeding. The average attributable hospital cost per surgical-site infection after cesarean delivery is estimated to be $3,529.
7
The skin is a major source of pathogens that cause surgical-site infections. Therefore, preoperative skin antisepsis . . .</description><subject>Adult</subject><subject>Anti-Infective Agents, Local - adverse effects</subject><subject>Anti-Infective Agents, Local - therapeutic use</subject><subject>Antimicrobial agents</subject><subject>Antisepsis - methods</subject><subject>Cesarean Section</subject><subject>Chlorhexidine</subject><subject>Chlorhexidine - adverse effects</subject><subject>Chlorhexidine - therapeutic use</subject><subject>Clinical trials</subject><subject>Evidence-based medicine</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Iodine</subject><subject>Iodine - adverse effects</subject><subject>Iodine - therapeutic use</subject><subject>Motivation</subject><subject>Pathogens</subject><subject>Pregnancy</subject><subject>Prevention</subject><subject>Skin</subject><subject>Skin - drug effects</subject><subject>Surgical site infections</subject><subject>Surgical Wound Infection - prevention & control</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kMFLwzAUh4Mobk6PXiUgHqtJm_Y1F2HM6ZSpoPMc0jSdmW06k24w_3orm8MdfJd3eB-_9_FD6JSSS0ri5Opp-PBYSxpTSli6h7o0jqKAMZLsoy4hYRow4FEHHXk_I-1Qxg9RJ0xSxlJGumjUxy_S5nVlvnSOJ87IEg_qai6dsVP8-mEs7tvGeD1vjML9qbaNx7LBA-2l09LiG12apXarY3RQyNLrk83uobfb4WQwCsbPd_eD_jhQrWITKMi5ykKpmALOcxJlaRGBTiXkMQuVAkhAx8AJBR7GWR6RAlJKmSp4rHScRD10vc6dL7JK56oVcrIUc2cq6VailkbsXqx5F9N6KRgARCG0AeebAFd_LrRvxKxeONs6CwpJEvIQKGupYE0pV3vvdLH9QIn4KV7sFN_yZ3-1tvRv0y1wsQaqygurZ9U_Qd_IaYmp</recordid><startdate>20160218</startdate><enddate>20160218</enddate><creator>Tuuli, Methodius G</creator><creator>Liu, Jingxia</creator><creator>Stout, Molly J</creator><creator>Martin, Shannon</creator><creator>Cahill, Alison G</creator><creator>Odibo, Anthony O</creator><creator>Colditz, Graham A</creator><creator>Macones, George A</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20160218</creationdate><title>A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery</title><author>Tuuli, Methodius G ; Liu, Jingxia ; Stout, Molly J ; Martin, Shannon ; Cahill, Alison G ; Odibo, Anthony O ; Colditz, Graham A ; Macones, George A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-c7d9cb2ac4c799d03b8f37e8a7d542cc7767e579017925bd30f78114cf95ce563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anti-Infective Agents, Local - adverse effects</topic><topic>Anti-Infective Agents, Local - therapeutic use</topic><topic>Antimicrobial agents</topic><topic>Antisepsis - methods</topic><topic>Cesarean Section</topic><topic>Chlorhexidine</topic><topic>Chlorhexidine - adverse effects</topic><topic>Chlorhexidine - therapeutic use</topic><topic>Clinical trials</topic><topic>Evidence-based medicine</topic><topic>Female</topic><topic>Humans</topic><topic>Infections</topic><topic>Iodine</topic><topic>Iodine - adverse effects</topic><topic>Iodine - therapeutic use</topic><topic>Motivation</topic><topic>Pathogens</topic><topic>Pregnancy</topic><topic>Prevention</topic><topic>Skin</topic><topic>Skin - drug effects</topic><topic>Surgical site infections</topic><topic>Surgical Wound Infection - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuuli, Methodius G</creatorcontrib><creatorcontrib>Liu, Jingxia</creatorcontrib><creatorcontrib>Stout, Molly J</creatorcontrib><creatorcontrib>Martin, Shannon</creatorcontrib><creatorcontrib>Cahill, Alison G</creatorcontrib><creatorcontrib>Odibo, Anthony O</creatorcontrib><creatorcontrib>Colditz, Graham A</creatorcontrib><creatorcontrib>Macones, George A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuuli, Methodius G</au><au>Liu, Jingxia</au><au>Stout, Molly J</au><au>Martin, Shannon</au><au>Cahill, Alison G</au><au>Odibo, Anthony O</au><au>Colditz, Graham A</au><au>Macones, George A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2016-02-18</date><risdate>2016</risdate><volume>374</volume><issue>7</issue><spage>647</spage><epage>55</epage><pages>647-55</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>In this single-center trial comparing chlorhexidine–alcohol with iodine–alcohol for skin antisepsis before cesarean delivery, the use of chlorhexidine–alcohol resulted in a risk of surgical-site infection that was significantly lower than that associated with iodine–alcohol.
Cesarean delivery is the most common major surgical procedure among women in the United States.
1
In 2013, more than 32.7% (1.3 million) of the 3.9 million births were by cesarean section.
2
Surgical-site infections complicate 2 to 5% of all surgical procedures and 5 to 12% of cesarean deliveries.
3
–
6
Infection occurring after delivery places an extra burden on the new mother and may impair mother–infant bonding and breast-feeding. The average attributable hospital cost per surgical-site infection after cesarean delivery is estimated to be $3,529.
7
The skin is a major source of pathogens that cause surgical-site infections. Therefore, preoperative skin antisepsis . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26844840</pmid><doi>10.1056/NEJMoa1511048</doi><tpages>-591</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2016-02, Vol.374 (7), p.647-55 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Anti-Infective Agents, Local - adverse effects Anti-Infective Agents, Local - therapeutic use Antimicrobial agents Antisepsis - methods Cesarean Section Chlorhexidine Chlorhexidine - adverse effects Chlorhexidine - therapeutic use Clinical trials Evidence-based medicine Female Humans Infections Iodine Iodine - adverse effects Iodine - therapeutic use Motivation Pathogens Pregnancy Prevention Skin Skin - drug effects Surgical site infections Surgical Wound Infection - prevention & control |
| title | A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery |
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