Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancom...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2016-03, Vol.60 (3), p.1865-1868 |
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| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 60 |
| creator | Albayati, Zaineb A F Sunkara, Manjula Schmidt-Malan, Suzannah M Karau, Melissa J Morris, Andrew J Steckelberg, James M Patel, Robin Breen, Philip J Smeltzer, Mark S Taylor, K Grant Merten, Kevyn E Pierce, William M Crooks, Peter A |
| description | We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome. |
| doi_str_mv | 10.1128/AAC.01609-15 |
| format | Article |
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The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01609-15</identifier><identifier>PMID: 26666918</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Anti-Bacterial Agents ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - therapeutic use ; Bone and Bones - metabolism ; Debridement ; Disease Models, Animal ; Drug Carriers ; Drug Carriers - therapeutic use ; Durapatite ; Durapatite - metabolism ; Experimental Therapeutics ; Humans ; Osteomyelitis ; Osteomyelitis - drug therapy ; Osteomyelitis - microbiology ; Polyethylene Glycols - chemistry ; Rats ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus aureus - drug effects ; Vancomycin ; Vancomycin - administration & dosage ; Vancomycin - pharmacokinetics ; Vancomycin - therapeutic use</subject><ispartof>Antimicrobial agents and chemotherapy, 2016-03, Vol.60 (3), p.1865-1868</ispartof><rights>Copyright © 2016, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2016, American Society for Microbiology. All Rights Reserved. 2016 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-4cc3a63111e691eb8a6e5a02c274e4752fbd5baaac5edcba252dedaf99455d013</citedby><cites>FETCH-LOGICAL-a418t-4cc3a63111e691eb8a6e5a02c274e4752fbd5baaac5edcba252dedaf99455d013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776008/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776008/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26666918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albayati, Zaineb A F</creatorcontrib><creatorcontrib>Sunkara, Manjula</creatorcontrib><creatorcontrib>Schmidt-Malan, Suzannah M</creatorcontrib><creatorcontrib>Karau, Melissa J</creatorcontrib><creatorcontrib>Morris, Andrew J</creatorcontrib><creatorcontrib>Steckelberg, James M</creatorcontrib><creatorcontrib>Patel, Robin</creatorcontrib><creatorcontrib>Breen, Philip J</creatorcontrib><creatorcontrib>Smeltzer, Mark S</creatorcontrib><creatorcontrib>Taylor, K Grant</creatorcontrib><creatorcontrib>Merten, Kevyn E</creatorcontrib><creatorcontrib>Pierce, William M</creatorcontrib><creatorcontrib>Crooks, Peter A</creatorcontrib><title>Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.</description><subject>Animals</subject><subject>Anti-Bacterial Agents</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bone and Bones - metabolism</subject><subject>Debridement</subject><subject>Disease Models, Animal</subject><subject>Drug Carriers</subject><subject>Drug Carriers - therapeutic use</subject><subject>Durapatite</subject><subject>Durapatite - metabolism</subject><subject>Experimental Therapeutics</subject><subject>Humans</subject><subject>Osteomyelitis</subject><subject>Osteomyelitis - drug therapy</subject><subject>Osteomyelitis - microbiology</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Rats</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Vancomycin</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - pharmacokinetics</subject><subject>Vancomycin - therapeutic use</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PwzAMhiMEgvFx44x6BImOpG3S9oJUxqc0wQW4Rm7qjqI2GUk7af-esA0EB3yxHD957bwh5JjRMWNRdlEUkzFlguYh41tkxGiehYLnYpuMKBUiTDKa7JF9596pr3lOd8leJHzkLBuR20ezwDa4MhrDZ7Az7Bs9C4oZ6j6ojQ1u9BtohVVwjW2zQLsMTB28-iPTLVWjg96s7h6SnRpah0ebfEBebm-eJ_fh9OnuYVJMQ0hY1oeJUjGImDGGfjyWGQjkQCMVpQkmKY_qsuIlACiOlSoh4lGFFdR5nnBeURYfkMu17nwoO4_4NS20cm6bDuxSGmjk345u3uTMLGSSpoLSzAucbgSs-RjQ9bJrnMK2BY1mcJKlIuN-QyE8er5GlTXOWax_xjAqv6yX3nq5sl4y7vGzNQ6ui-S7Gaz2TvzHnvx-xo_w97_En2wtjB8</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Albayati, Zaineb A F</creator><creator>Sunkara, Manjula</creator><creator>Schmidt-Malan, Suzannah M</creator><creator>Karau, Melissa J</creator><creator>Morris, Andrew J</creator><creator>Steckelberg, James M</creator><creator>Patel, Robin</creator><creator>Breen, Philip J</creator><creator>Smeltzer, Mark S</creator><creator>Taylor, K Grant</creator><creator>Merten, Kevyn E</creator><creator>Pierce, William M</creator><creator>Crooks, Peter A</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone</title><author>Albayati, Zaineb A F ; Sunkara, Manjula ; Schmidt-Malan, Suzannah M ; Karau, Melissa J ; Morris, Andrew J ; Steckelberg, James M ; Patel, Robin ; Breen, Philip J ; Smeltzer, Mark S ; Taylor, K Grant ; Merten, Kevyn E ; Pierce, William M ; Crooks, Peter A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-4cc3a63111e691eb8a6e5a02c274e4752fbd5baaac5edcba252dedaf99455d013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bone and Bones - metabolism</topic><topic>Debridement</topic><topic>Disease Models, Animal</topic><topic>Drug Carriers</topic><topic>Drug Carriers - therapeutic use</topic><topic>Durapatite</topic><topic>Durapatite - metabolism</topic><topic>Experimental Therapeutics</topic><topic>Humans</topic><topic>Osteomyelitis</topic><topic>Osteomyelitis - drug therapy</topic><topic>Osteomyelitis - microbiology</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Rats</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Vancomycin</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - pharmacokinetics</topic><topic>Vancomycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albayati, Zaineb A F</creatorcontrib><creatorcontrib>Sunkara, Manjula</creatorcontrib><creatorcontrib>Schmidt-Malan, Suzannah M</creatorcontrib><creatorcontrib>Karau, Melissa J</creatorcontrib><creatorcontrib>Morris, Andrew J</creatorcontrib><creatorcontrib>Steckelberg, James M</creatorcontrib><creatorcontrib>Patel, Robin</creatorcontrib><creatorcontrib>Breen, Philip J</creatorcontrib><creatorcontrib>Smeltzer, Mark S</creatorcontrib><creatorcontrib>Taylor, K Grant</creatorcontrib><creatorcontrib>Merten, Kevyn E</creatorcontrib><creatorcontrib>Pierce, William M</creatorcontrib><creatorcontrib>Crooks, Peter A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albayati, Zaineb A F</au><au>Sunkara, Manjula</au><au>Schmidt-Malan, Suzannah M</au><au>Karau, Melissa J</au><au>Morris, Andrew J</au><au>Steckelberg, James M</au><au>Patel, Robin</au><au>Breen, Philip J</au><au>Smeltzer, Mark S</au><au>Taylor, K Grant</au><au>Merten, Kevyn E</au><au>Pierce, William M</au><au>Crooks, Peter A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>60</volume><issue>3</issue><spage>1865</spage><epage>1868</epage><pages>1865-1868</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>26666918</pmid><doi>10.1128/AAC.01609-15</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Anti-Bacterial Agents Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Bone and Bones - metabolism Debridement Disease Models, Animal Drug Carriers Drug Carriers - therapeutic use Durapatite Durapatite - metabolism Experimental Therapeutics Humans Osteomyelitis Osteomyelitis - drug therapy Osteomyelitis - microbiology Polyethylene Glycols - chemistry Rats Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Vancomycin Vancomycin - administration & dosage Vancomycin - pharmacokinetics Vancomycin - therapeutic use |
| title | Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone |
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