Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy
Adjuvant chemotherapy is benefit for high-risk stage II and stage III colon cancer after curative resection. But, the optimal time between surgical and initiation of adjuvant chemotherapy remains unclear. Moreover, no study of efficacy with different lengths of adjuvant chemotherapy has appeared. Th...
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| Veröffentlicht in: | Indian journal of surgery 2015-12, Vol.77 (Suppl 3), p.1252-1257 |
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| creator | Jeong, In Seob Yoo, Jong Han Seo, Sang Hyuk An, Min Sung Kim, Kwang Hee Bae, Ki Beom Choi, Chang Soo Hwang, Jin Won Kim, Ji Hyun Kang, Mi Seon Oh, Min Kyung Hong, Kwan Hee |
| description | Adjuvant chemotherapy is benefit for high-risk stage II and stage III colon cancer after curative resection. But, the optimal time between surgical and initiation of adjuvant chemotherapy remains unclear. Moreover, no study of efficacy with different lengths of adjuvant chemotherapy has appeared. This study was aimed to identify association between time (initiation and length) and oncological outcomes of adjuvant chemotherapy on the stages II and III colon cancer patients. A total of 406 high-risk stages II and III colon cancer patients were retrospectively enrolled in prospectively collected data. They were categorized into three groups representing chemotherapy initiation time: less than 4 weeks (group 1), 4 to 6 weeks (group 2), and more than 6 weeks (group 3). They were categorized into two groups representing chemotherapy length time : less than 200 days (group 1a) and more than 200 days (group 2a). The 5-year disease-free survival (DFS) rates were 74.97 % in group 1, 76.94 % in group 2, and 63.97 % in group 3 (
p
> 0.05). The 5-year DFS rates were 75.49 % in the group that received adjuvant chemotherapy within 6 weeks and 63.97 % in the group that received adjuvant chemotherapy >6 weeks (
p
= 0.0539). The 5-year DFS rates were 77.21 % in group 1a and 81.82 % in group 2a (
p
> 0.05). Adjuvant chemotherapy should be safely offered within 6 weeks after surgical excision in patients with colon cancer after considering the patient’s general physical condition and hematological factors, even if the chemotherapy length is prolonged. |
| doi_str_mv | 10.1007/s12262-015-1270-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4775653</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A444941823</galeid><sourcerecordid>A444941823</sourcerecordid><originalsourceid>FETCH-LOGICAL-c607t-bd1648c0490ac868afee602164ad5d5e96938ef3460577a60b61c9a14c7b656b3</originalsourceid><addsrcrecordid>eNp1Us1u1DAQjhCIlsIDcEGWuJRDiu04dnJBWla0VFppOSxny3Emu14l9mI7rfoUvDJOs5QWgXzwaL6f8Vhflr0l-IJgLD4GQimnOSZlTqjAefEsO8W1KPJa1MXz-5rmFPPqJHsVwh5jynhRvMxOEpmQkonT7OciBKeNisZZ9BniLYBFGzMAOr-2Jh4BZVu0AruNuw_39dpq17ut0apH6zFqN0BAnfMo7gB9SxqwMaBbE3domYgWLZXV4NHGg4rQzsii3Y83yka03MHgktKrw93r7EWn-gBvjvdZ9v3yy2b5NV-tr66Xi1WuORYxb1rCWaUxq7HSFa9UB8AxTU3Vlm0JNa-LCrqCcVwKoThuONG1IkyLhpe8Kc6yT7PvYWwGaHV6sFe9PHgzKH8nnTLyKWLNTm7djWRClLwsksH50cC7HyOEKAcTNPS9suDGIIkQHFei5iJR3_9F3bvR27SeJJUgJWUlq_6wtqoHaWzn0lw9mcoFY6xmpKLT2It_sNJpYTDaWehM6j8RkFmgvQvBQ_ewI8FySpGcUyRTiuSUIjlp3j3-nAfF79gkAp0JIUF2C_7RRv91_QX9pdKC</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1871524548</pqid></control><display><type>article</type><title>Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy</title><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Jeong, In Seob ; Yoo, Jong Han ; Seo, Sang Hyuk ; An, Min Sung ; Kim, Kwang Hee ; Bae, Ki Beom ; Choi, Chang Soo ; Hwang, Jin Won ; Kim, Ji Hyun ; Kang, Mi Seon ; Oh, Min Kyung ; Hong, Kwan Hee</creator><creatorcontrib>Jeong, In Seob ; Yoo, Jong Han ; Seo, Sang Hyuk ; An, Min Sung ; Kim, Kwang Hee ; Bae, Ki Beom ; Choi, Chang Soo ; Hwang, Jin Won ; Kim, Ji Hyun ; Kang, Mi Seon ; Oh, Min Kyung ; Hong, Kwan Hee</creatorcontrib><description>Adjuvant chemotherapy is benefit for high-risk stage II and stage III colon cancer after curative resection. But, the optimal time between surgical and initiation of adjuvant chemotherapy remains unclear. Moreover, no study of efficacy with different lengths of adjuvant chemotherapy has appeared. This study was aimed to identify association between time (initiation and length) and oncological outcomes of adjuvant chemotherapy on the stages II and III colon cancer patients. A total of 406 high-risk stages II and III colon cancer patients were retrospectively enrolled in prospectively collected data. They were categorized into three groups representing chemotherapy initiation time: less than 4 weeks (group 1), 4 to 6 weeks (group 2), and more than 6 weeks (group 3). They were categorized into two groups representing chemotherapy length time : less than 200 days (group 1a) and more than 200 days (group 2a). The 5-year disease-free survival (DFS) rates were 74.97 % in group 1, 76.94 % in group 2, and 63.97 % in group 3 (
p
> 0.05). The 5-year DFS rates were 75.49 % in the group that received adjuvant chemotherapy within 6 weeks and 63.97 % in the group that received adjuvant chemotherapy >6 weeks (
p
= 0.0539). The 5-year DFS rates were 77.21 % in group 1a and 81.82 % in group 2a (
p
> 0.05). Adjuvant chemotherapy should be safely offered within 6 weeks after surgical excision in patients with colon cancer after considering the patient’s general physical condition and hematological factors, even if the chemotherapy length is prolonged.</description><identifier>ISSN: 0972-2068</identifier><identifier>EISSN: 0973-9793</identifier><identifier>DOI: 10.1007/s12262-015-1270-3</identifier><identifier>PMID: 27011547</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adjuvant chemotherapy ; Cancer patients ; Cardiac Surgery ; Care and treatment ; Chemotherapy ; Clinical outcomes ; Colon cancer ; Colorectal cancer ; Colorectal surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Original ; Original Article ; Patient outcomes ; Pediatric Surgery ; Plastic Surgery ; Surgery ; Thoracic Surgery ; Timing issues</subject><ispartof>Indian journal of surgery, 2015-12, Vol.77 (Suppl 3), p.1252-1257</ispartof><rights>Association of Surgeons of India 2015</rights><rights>COPYRIGHT 2015 Springer</rights><rights>Indian Journal of Surgery is a copyright of Springer, 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-bd1648c0490ac868afee602164ad5d5e96938ef3460577a60b61c9a14c7b656b3</citedby><cites>FETCH-LOGICAL-c607t-bd1648c0490ac868afee602164ad5d5e96938ef3460577a60b61c9a14c7b656b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775653/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775653/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27011547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, In Seob</creatorcontrib><creatorcontrib>Yoo, Jong Han</creatorcontrib><creatorcontrib>Seo, Sang Hyuk</creatorcontrib><creatorcontrib>An, Min Sung</creatorcontrib><creatorcontrib>Kim, Kwang Hee</creatorcontrib><creatorcontrib>Bae, Ki Beom</creatorcontrib><creatorcontrib>Choi, Chang Soo</creatorcontrib><creatorcontrib>Hwang, Jin Won</creatorcontrib><creatorcontrib>Kim, Ji Hyun</creatorcontrib><creatorcontrib>Kang, Mi Seon</creatorcontrib><creatorcontrib>Oh, Min Kyung</creatorcontrib><creatorcontrib>Hong, Kwan Hee</creatorcontrib><title>Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy</title><title>Indian journal of surgery</title><addtitle>Indian J Surg</addtitle><addtitle>Indian J Surg</addtitle><description>Adjuvant chemotherapy is benefit for high-risk stage II and stage III colon cancer after curative resection. But, the optimal time between surgical and initiation of adjuvant chemotherapy remains unclear. Moreover, no study of efficacy with different lengths of adjuvant chemotherapy has appeared. This study was aimed to identify association between time (initiation and length) and oncological outcomes of adjuvant chemotherapy on the stages II and III colon cancer patients. A total of 406 high-risk stages II and III colon cancer patients were retrospectively enrolled in prospectively collected data. They were categorized into three groups representing chemotherapy initiation time: less than 4 weeks (group 1), 4 to 6 weeks (group 2), and more than 6 weeks (group 3). They were categorized into two groups representing chemotherapy length time : less than 200 days (group 1a) and more than 200 days (group 2a). The 5-year disease-free survival (DFS) rates were 74.97 % in group 1, 76.94 % in group 2, and 63.97 % in group 3 (
p
> 0.05). The 5-year DFS rates were 75.49 % in the group that received adjuvant chemotherapy within 6 weeks and 63.97 % in the group that received adjuvant chemotherapy >6 weeks (
p
= 0.0539). The 5-year DFS rates were 77.21 % in group 1a and 81.82 % in group 2a (
p
> 0.05). Adjuvant chemotherapy should be safely offered within 6 weeks after surgical excision in patients with colon cancer after considering the patient’s general physical condition and hematological factors, even if the chemotherapy length is prolonged.</description><subject>Adjuvant chemotherapy</subject><subject>Cancer patients</subject><subject>Cardiac Surgery</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Original</subject><subject>Original Article</subject><subject>Patient outcomes</subject><subject>Pediatric Surgery</subject><subject>Plastic Surgery</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Timing issues</subject><issn>0972-2068</issn><issn>0973-9793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1Us1u1DAQjhCIlsIDcEGWuJRDiu04dnJBWla0VFppOSxny3Emu14l9mI7rfoUvDJOs5QWgXzwaL6f8Vhflr0l-IJgLD4GQimnOSZlTqjAefEsO8W1KPJa1MXz-5rmFPPqJHsVwh5jynhRvMxOEpmQkonT7OciBKeNisZZ9BniLYBFGzMAOr-2Jh4BZVu0AruNuw_39dpq17ut0apH6zFqN0BAnfMo7gB9SxqwMaBbE3domYgWLZXV4NHGg4rQzsii3Y83yka03MHgktKrw93r7EWn-gBvjvdZ9v3yy2b5NV-tr66Xi1WuORYxb1rCWaUxq7HSFa9UB8AxTU3Vlm0JNa-LCrqCcVwKoThuONG1IkyLhpe8Kc6yT7PvYWwGaHV6sFe9PHgzKH8nnTLyKWLNTm7djWRClLwsksH50cC7HyOEKAcTNPS9suDGIIkQHFei5iJR3_9F3bvR27SeJJUgJWUlq_6wtqoHaWzn0lw9mcoFY6xmpKLT2It_sNJpYTDaWehM6j8RkFmgvQvBQ_ewI8FySpGcUyRTiuSUIjlp3j3-nAfF79gkAp0JIUF2C_7RRv91_QX9pdKC</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Jeong, In Seob</creator><creator>Yoo, Jong Han</creator><creator>Seo, Sang Hyuk</creator><creator>An, Min Sung</creator><creator>Kim, Kwang Hee</creator><creator>Bae, Ki Beom</creator><creator>Choi, Chang Soo</creator><creator>Hwang, Jin Won</creator><creator>Kim, Ji Hyun</creator><creator>Kang, Mi Seon</creator><creator>Oh, Min Kyung</creator><creator>Hong, Kwan Hee</creator><general>Springer India</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04T</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy</title><author>Jeong, In Seob ; Yoo, Jong Han ; Seo, Sang Hyuk ; An, Min Sung ; Kim, Kwang Hee ; Bae, Ki Beom ; Choi, Chang Soo ; Hwang, Jin Won ; Kim, Ji Hyun ; Kang, Mi Seon ; Oh, Min Kyung ; Hong, Kwan Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-bd1648c0490ac868afee602164ad5d5e96938ef3460577a60b61c9a14c7b656b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adjuvant chemotherapy</topic><topic>Cancer patients</topic><topic>Cardiac Surgery</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Original</topic><topic>Original Article</topic><topic>Patient outcomes</topic><topic>Pediatric Surgery</topic><topic>Plastic Surgery</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Timing issues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, In Seob</creatorcontrib><creatorcontrib>Yoo, Jong Han</creatorcontrib><creatorcontrib>Seo, Sang Hyuk</creatorcontrib><creatorcontrib>An, Min Sung</creatorcontrib><creatorcontrib>Kim, Kwang Hee</creatorcontrib><creatorcontrib>Bae, Ki Beom</creatorcontrib><creatorcontrib>Choi, Chang Soo</creatorcontrib><creatorcontrib>Hwang, Jin Won</creatorcontrib><creatorcontrib>Kim, Ji Hyun</creatorcontrib><creatorcontrib>Kang, Mi Seon</creatorcontrib><creatorcontrib>Oh, Min Kyung</creatorcontrib><creatorcontrib>Hong, Kwan Hee</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Health & Medicine</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, In Seob</au><au>Yoo, Jong Han</au><au>Seo, Sang Hyuk</au><au>An, Min Sung</au><au>Kim, Kwang Hee</au><au>Bae, Ki Beom</au><au>Choi, Chang Soo</au><au>Hwang, Jin Won</au><au>Kim, Ji Hyun</au><au>Kang, Mi Seon</au><au>Oh, Min Kyung</au><au>Hong, Kwan Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy</atitle><jtitle>Indian journal of surgery</jtitle><stitle>Indian J Surg</stitle><addtitle>Indian J Surg</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>77</volume><issue>Suppl 3</issue><spage>1252</spage><epage>1257</epage><pages>1252-1257</pages><issn>0972-2068</issn><eissn>0973-9793</eissn><abstract>Adjuvant chemotherapy is benefit for high-risk stage II and stage III colon cancer after curative resection. But, the optimal time between surgical and initiation of adjuvant chemotherapy remains unclear. Moreover, no study of efficacy with different lengths of adjuvant chemotherapy has appeared. This study was aimed to identify association between time (initiation and length) and oncological outcomes of adjuvant chemotherapy on the stages II and III colon cancer patients. A total of 406 high-risk stages II and III colon cancer patients were retrospectively enrolled in prospectively collected data. They were categorized into three groups representing chemotherapy initiation time: less than 4 weeks (group 1), 4 to 6 weeks (group 2), and more than 6 weeks (group 3). They were categorized into two groups representing chemotherapy length time : less than 200 days (group 1a) and more than 200 days (group 2a). The 5-year disease-free survival (DFS) rates were 74.97 % in group 1, 76.94 % in group 2, and 63.97 % in group 3 (
p
> 0.05). The 5-year DFS rates were 75.49 % in the group that received adjuvant chemotherapy within 6 weeks and 63.97 % in the group that received adjuvant chemotherapy >6 weeks (
p
= 0.0539). The 5-year DFS rates were 77.21 % in group 1a and 81.82 % in group 2a (
p
> 0.05). Adjuvant chemotherapy should be safely offered within 6 weeks after surgical excision in patients with colon cancer after considering the patient’s general physical condition and hematological factors, even if the chemotherapy length is prolonged.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>27011547</pmid><doi>10.1007/s12262-015-1270-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adjuvant chemotherapy Cancer patients Cardiac Surgery Care and treatment Chemotherapy Clinical outcomes Colon cancer Colorectal cancer Colorectal surgery Medicine Medicine & Public Health Neurosurgery Original Original Article Patient outcomes Pediatric Surgery Plastic Surgery Surgery Thoracic Surgery Timing issues |
| title | Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy |
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