Natural history of muscle cramps in amyotrophic lateral sclerosis
ABSTRACT Introduction: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. Methods: We surveyed early stage ALS patients about their exper...
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| Veröffentlicht in: | Muscle & nerve 2016-04, Vol.53 (4), p.513-517 |
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| creator | Caress, James B. Ciarlone, Stephanie L. Sullivan, Elizabeth A. Griffin, Leah P. Cartwright, Michael S. |
| description | ABSTRACT
Introduction: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. Methods: We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. Results: Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from month‐to‐month and trended lower after the first year of illness (P = 0.26). Those with limb‐onset and age >60 years had more cramps than bulbar‐onset (P < 0.0001) and younger patients (P < 0.0001). Conclusions: The high variability of the number of cramps experienced suggests that clinical trials will need to use crossover designs or large numbers of participants, even when the treatment effect is substantial. Muscle Nerve 53: 513–517, 2016 |
| doi_str_mv | 10.1002/mus.24892 |
| format | Article |
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Introduction: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. Methods: We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. Results: Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from month‐to‐month and trended lower after the first year of illness (P = 0.26). Those with limb‐onset and age >60 years had more cramps than bulbar‐onset (P < 0.0001) and younger patients (P < 0.0001). Conclusions: The high variability of the number of cramps experienced suggests that clinical trials will need to use crossover designs or large numbers of participants, even when the treatment effect is substantial. Muscle Nerve 53: 513–517, 2016</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.24892</identifier><identifier>PMID: 26332705</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - diagnosis ; Amyotrophic Lateral Sclerosis - epidemiology ; Amyotrophic Lateral Sclerosis - physiopathology ; Clinical trials ; cramps ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Muscle Cramp - diagnosis ; Muscle Cramp - epidemiology ; Muscle Cramp - physiopathology ; muscle spasms ; natural history ; pain ; Surveys and Questionnaires</subject><ispartof>Muscle & nerve, 2016-04, Vol.53 (4), p.513-517</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6502-7a6a4c932bdbde181cce16f0ba27d1c2076099dfdf4898d3b8d862d79d96af4d3</citedby><cites>FETCH-LOGICAL-c6502-7a6a4c932bdbde181cce16f0ba27d1c2076099dfdf4898d3b8d862d79d96af4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.24892$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.24892$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26332705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caress, James B.</creatorcontrib><creatorcontrib>Ciarlone, Stephanie L.</creatorcontrib><creatorcontrib>Sullivan, Elizabeth A.</creatorcontrib><creatorcontrib>Griffin, Leah P.</creatorcontrib><creatorcontrib>Cartwright, Michael S.</creatorcontrib><title>Natural history of muscle cramps in amyotrophic lateral sclerosis</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. Methods: We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. Results: Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from month‐to‐month and trended lower after the first year of illness (P = 0.26). Those with limb‐onset and age >60 years had more cramps than bulbar‐onset (P < 0.0001) and younger patients (P < 0.0001). Conclusions: The high variability of the number of cramps experienced suggests that clinical trials will need to use crossover designs or large numbers of participants, even when the treatment effect is substantial. Muscle Nerve 53: 513–517, 2016</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - diagnosis</subject><subject>Amyotrophic Lateral Sclerosis - epidemiology</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Clinical trials</subject><subject>cramps</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Cramp - diagnosis</subject><subject>Muscle Cramp - epidemiology</subject><subject>Muscle Cramp - physiopathology</subject><subject>muscle spasms</subject><subject>natural history</subject><subject>pain</subject><subject>Surveys and Questionnaires</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1rFDEUhkNR2rV64R8oA97oxbT5_rgRyqKtUGtBi6U3IZNkumlnJmsyo-6_N-u2ixUEr3KR5zyc874AvETwEEGIj_opH2IqFd4BMwSVqClT8gmYQURlzYm62gPPcr6FECLJxS7Yw5wQLCCbgeNzM07JdNUi5DGmVRXbquhs5yubTL_MVRgq06_imOJyEWzVmdGv-TWSYg75OXjami77F_fvPrh8_-7L_LQ--3TyYX58VlvOIK6F4YZaRXDjGueRRNZ6xFvYGCwcshgKDpVyrWvLIdKRRjrJsRPKKW5a6sg-eLvxLqem9876YSx76GUKvUkrHU3Qj3-GsNA38bumQjDKUBG8vhek-G3yedR9yNZ3nRl8nLJGQkIGERPqP1DBEOeE4YK--gu9jVMaShJrilIsmCCFerOhbMksJ99u90ZQrzvUJXT9u8PCHvx56JZ8KK0ARxvgR-j86t8m_fHy84Oy3kyUkv3P7YRJd5oLIpj-en6i5_z0-kJeKI3JL1H5thI</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Caress, James B.</creator><creator>Ciarlone, Stephanie L.</creator><creator>Sullivan, Elizabeth A.</creator><creator>Griffin, Leah P.</creator><creator>Cartwright, Michael S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201604</creationdate><title>Natural history of muscle cramps in amyotrophic lateral sclerosis</title><author>Caress, James B. ; Ciarlone, Stephanie L. ; Sullivan, Elizabeth A. ; Griffin, Leah P. ; Cartwright, Michael S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6502-7a6a4c932bdbde181cce16f0ba27d1c2076099dfdf4898d3b8d862d79d96af4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - diagnosis</topic><topic>Amyotrophic Lateral Sclerosis - epidemiology</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Clinical trials</topic><topic>cramps</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Cramp - diagnosis</topic><topic>Muscle Cramp - epidemiology</topic><topic>Muscle Cramp - physiopathology</topic><topic>muscle spasms</topic><topic>natural history</topic><topic>pain</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caress, James B.</creatorcontrib><creatorcontrib>Ciarlone, Stephanie L.</creatorcontrib><creatorcontrib>Sullivan, Elizabeth A.</creatorcontrib><creatorcontrib>Griffin, Leah P.</creatorcontrib><creatorcontrib>Cartwright, Michael S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caress, James B.</au><au>Ciarlone, Stephanie L.</au><au>Sullivan, Elizabeth A.</au><au>Griffin, Leah P.</au><au>Cartwright, Michael S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural history of muscle cramps in amyotrophic lateral sclerosis</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2016-04</date><risdate>2016</risdate><volume>53</volume><issue>4</issue><spage>513</spage><epage>517</epage><pages>513-517</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>ABSTRACT
Introduction: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. Methods: We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. Results: Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from month‐to‐month and trended lower after the first year of illness (P = 0.26). Those with limb‐onset and age >60 years had more cramps than bulbar‐onset (P < 0.0001) and younger patients (P < 0.0001). Conclusions: The high variability of the number of cramps experienced suggests that clinical trials will need to use crossover designs or large numbers of participants, even when the treatment effect is substantial. Muscle Nerve 53: 513–517, 2016</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26332705</pmid><doi>10.1002/mus.24892</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - epidemiology Amyotrophic Lateral Sclerosis - physiopathology Clinical trials cramps Female Humans Longitudinal Studies Male Middle Aged Muscle Cramp - diagnosis Muscle Cramp - epidemiology Muscle Cramp - physiopathology muscle spasms natural history pain Surveys and Questionnaires |
| title | Natural history of muscle cramps in amyotrophic lateral sclerosis |
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