Protease inhibitors targeting coronavirus and filovirus entry

•We identify vinylsulfones as lead candidate inhibitors of Ebola virus and SARS-CoV.•K11777 inhibited Ebola virus and SARS-CoV entry in the sub-nanomolar range.•Potent inhibition correlated with the presence of a basic piperazine ring at P3.•Serine protease inhibitor and K11777 blocked coronavirus e...

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Veröffentlicht in:	Antiviral research 2015-04, Vol.116, p.76-84
Hauptverfasser:	Zhou, Yanchen, Vedantham, Punitha, Lu, Kai, Agudelo, Juliet, Carrion, Ricardo, Nunneley, Jerritt W., Barnard, Dale, Pöhlmann, Stefan, McKerrow, James H., Renslo, Adam R., Simmons, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Cathepsin Cathepsins - metabolism Cell Line, Tumor Coronavirus Coronavirus - drug effects Coronavirus - physiology Coronavirus Infections - drug therapy Dipeptides - pharmacology Ebola virus Ebolavirus - drug effects Ebolavirus - physiology Filoviridae - drug effects Filoviridae - physiology Filovirus Gabexate - analogs & derivatives Gabexate - pharmacology Humans Mice Mice, Inbred BALB C Protease Inhibitors - pharmacology SARS coronavirus SARS Virus - drug effects SARS Virus - physiology Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - pharmacology Vinyl Compounds - pharmacology Vinylsulfones Virus Internalization - drug effects
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