Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature
Richter's transformation induces an aggressive clinical course in chronic lymphocytic leukemia (CLL). In the majority of cases, Richter's transformation manifests itself as a high-grade B-cell non-Hodgkin's lymphoma (B-NHL). However, other histological types, such as classical Hodgkin...
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| Veröffentlicht in: | Molecular and clinical oncology 2016-03, Vol.4 (3), p.390-392 |
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| creator | JANJETOVIC, SNJEZANA BERND, HEINZ-WOLFRAM BOKEMEYER, CARSTEN FIEDLER, WALTER |
| description | Richter's transformation induces an aggressive clinical course in chronic lymphocytic leukemia (CLL). In the majority of cases, Richter's transformation manifests itself as a high-grade B-cell non-Hodgkin's lymphoma (B-NHL). However, other histological types, such as classical Hodgkin lymphoma (cHL), lymphoblastic lymphoma, hairy cell leukemia and high-grade T-cell NHL have been described previously. The present study reports a rare case of CLL with transformation into classical Hodgkin's lymphoma (cHL). The common clonal origin of CLL and cHL was documented by immunoglobulin gene rearrangement analysis performed using multiplex polymerase chain reaction. Following a review of the literature, treatment of secondary Hodgkin's lymphoma is discussed, and prognosis is often poor. |
| doi_str_mv | 10.3892/mco.2016.727 |
| format | Article |
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In the majority of cases, Richter's transformation manifests itself as a high-grade B-cell non-Hodgkin's lymphoma (B-NHL). However, other histological types, such as classical Hodgkin lymphoma (cHL), lymphoblastic lymphoma, hairy cell leukemia and high-grade T-cell NHL have been described previously. The present study reports a rare case of CLL with transformation into classical Hodgkin's lymphoma (cHL). The common clonal origin of CLL and cHL was documented by immunoglobulin gene rearrangement analysis performed using multiplex polymerase chain reaction. Following a review of the literature, treatment of secondary Hodgkin's lymphoma is discussed, and prognosis is often poor.</description><identifier>ISSN: 2049-9450</identifier><identifier>EISSN: 2049-9469</identifier><identifier>DOI: 10.3892/mco.2016.727</identifier><identifier>PMID: 26998289</identifier><language>eng</language><publisher>England: D.A. Spandidos</publisher><subject>Bone marrow ; Care and treatment ; Case reports ; Case studies ; Chemotherapy ; Chronic lymphocytic leukemia ; Complications and side effects ; Development and progression ; Hodgkin's disease ; Immunoglobulins ; Leukemia ; Lymphocytes ; Lymphoma ; Medical prognosis ; Oncology ; Patients ; Richter transformation</subject><ispartof>Molecular and clinical oncology, 2016-03, Vol.4 (3), p.390-392</ispartof><rights>Copyright: © Janjetovic et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Janjetovic et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-3aa6adfe014c6e09e103bb7ffa77fdee9412a0d085a73b95b993427f1e9debfe3</citedby><cites>FETCH-LOGICAL-c438t-3aa6adfe014c6e09e103bb7ffa77fdee9412a0d085a73b95b993427f1e9debfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774418/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774418/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,5571,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26998289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JANJETOVIC, SNJEZANA</creatorcontrib><creatorcontrib>BERND, HEINZ-WOLFRAM</creatorcontrib><creatorcontrib>BOKEMEYER, CARSTEN</creatorcontrib><creatorcontrib>FIEDLER, WALTER</creatorcontrib><title>Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>Richter's transformation induces an aggressive clinical course in chronic lymphocytic leukemia (CLL). In the majority of cases, Richter's transformation manifests itself as a high-grade B-cell non-Hodgkin's lymphoma (B-NHL). However, other histological types, such as classical Hodgkin lymphoma (cHL), lymphoblastic lymphoma, hairy cell leukemia and high-grade T-cell NHL have been described previously. The present study reports a rare case of CLL with transformation into classical Hodgkin's lymphoma (cHL). The common clonal origin of CLL and cHL was documented by immunoglobulin gene rearrangement analysis performed using multiplex polymerase chain reaction. Following a review of the literature, treatment of secondary Hodgkin's lymphoma is discussed, and prognosis is often poor.</description><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Case studies</subject><subject>Chemotherapy</subject><subject>Chronic lymphocytic leukemia</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Hodgkin's disease</subject><subject>Immunoglobulins</subject><subject>Leukemia</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Medical prognosis</subject><subject>Oncology</subject><subject>Patients</subject><subject>Richter transformation</subject><issn>2049-9450</issn><issn>2049-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk2LFDEQhhtR3GXdm2cJKOjBHpN0-iMehGFQV1hZED2H6nRlJrvdyZh0j8x_8EebZsbRFVOHFMlTb6jKm2VPGV0UjeRvBu0XnLJqUfP6QXbOqZC5FJV8eMpLepZdxnhL05I15aV8nJ3xSsqGN_I8-3nlu_WddS8j6ffDduMHIBAJkAAByQ6CBTcSb8gXqzcjhsSNAVw0PgwwWu-IdURvgndWHxX0fpxznO5wsPCWLImGiCTg1oeRgOtSurP4Y1YdN0h6m3RhnAI-yR4Z6CNeHveL7NuH919XV_n1zcdPq-V1rkXRjHkBUEFnkDKhK6QSGS3atjYG6tp0iFIwDrSjTQl10cqylbIQvDYMZYetweIie3fQ3U7tgJ1Gl3rq1TbYAcJeebDq_o2zG7X2OyXqWgjWJIFXR4Hgv08YRzXYqLHvwaGfomINr6oqTZkm9Pk_6K2fgkvtKSYLnv6noPIPtYYelXXGp3f1LKqWQjS0YGUzU4v_UCm6NGntHRqbzu8VvD4U6OBjDGhOPTKqZgOpZCA1G0glAyX82d9zOcG_7ZKAFwcgbtM_2s7HE_N5dZPTFLPOL7HFzyw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>JANJETOVIC, SNJEZANA</creator><creator>BERND, HEINZ-WOLFRAM</creator><creator>BOKEMEYER, CARSTEN</creator><creator>FIEDLER, WALTER</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature</title><author>JANJETOVIC, SNJEZANA ; BERND, HEINZ-WOLFRAM ; BOKEMEYER, CARSTEN ; FIEDLER, WALTER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-3aa6adfe014c6e09e103bb7ffa77fdee9412a0d085a73b95b993427f1e9debfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Bone marrow</topic><topic>Care and treatment</topic><topic>Case reports</topic><topic>Case studies</topic><topic>Chemotherapy</topic><topic>Chronic lymphocytic leukemia</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Hodgkin's disease</topic><topic>Immunoglobulins</topic><topic>Leukemia</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Medical prognosis</topic><topic>Oncology</topic><topic>Patients</topic><topic>Richter transformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JANJETOVIC, SNJEZANA</creatorcontrib><creatorcontrib>BERND, HEINZ-WOLFRAM</creatorcontrib><creatorcontrib>BOKEMEYER, CARSTEN</creatorcontrib><creatorcontrib>FIEDLER, WALTER</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JANJETOVIC, SNJEZANA</au><au>BERND, HEINZ-WOLFRAM</au><au>BOKEMEYER, CARSTEN</au><au>FIEDLER, WALTER</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature</atitle><jtitle>Molecular and clinical oncology</jtitle><addtitle>Mol Clin Oncol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>4</volume><issue>3</issue><spage>390</spage><epage>392</epage><pages>390-392</pages><issn>2049-9450</issn><eissn>2049-9469</eissn><abstract>Richter's transformation induces an aggressive clinical course in chronic lymphocytic leukemia (CLL). 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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Bone marrow Care and treatment Case reports Case studies Chemotherapy Chronic lymphocytic leukemia Complications and side effects Development and progression Hodgkin's disease Immunoglobulins Leukemia Lymphocytes Lymphoma Medical prognosis Oncology Patients Richter transformation |
| title | Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature |
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