Curcumin suppresses transforming growth factor-β1-induced cardiac fibroblast differentiation via inhibition of Smad-2 and p38 MAPK signaling pathways

The differentiation of cardiac fibroblasts (CFs) into myofibroblasts and the subsequent deposition of the extracellular matrix is associated with myocardial fibrosis following various types of myocardial injury. In the present study, the effect of curcumin, which is a pharmacologically-safe natural...

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Veröffentlicht in:	Experimental and therapeutic medicine 2016-03, Vol.11 (3), p.998-1004
Hauptverfasser:	LIU, HUZI, LIU, AIJUN, SHI, CHUNLI, LI, BAO
Format:	Artikel
Sprache:	eng
Schlagworte:	cardiac fibroblast Cell culture Cell differentiation Collagen curcumin Fibroblasts Genetic aspects Growth factors Heart failure Immunoglobulins Kinases Laboratory animals p38 mitogen-activated protein kinase Phosphorylation Physiological aspects Proteins Rodents Smad2 Studies transforming growth factor-β1 Transforming growth factors Turmeric
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