Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

Abstract β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked APP-βCTF generated by BACE1 (β-APP cleaving enzyme 1) to the development of endocytic abnormalities and cholinergic neur...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 2016-03, Vol.39, p.90-98
Hauptverfasser:	Jiang, Ying, Rigoglioso, Andrew, Peterhoff, Corrinne M, Pawlik, Monika, Sato, Yutaka, Bleiwas, Cynthia, Stavrides, Philip, Smiley, John F, Ginsberg, Stephen D, Mathews, Paul M, Levy, Efrat, Nixon, Ralph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - pathology Alleles Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - physiology Amyloid beta-Protein Precursor - physiology Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - physiology Animals APP-βCTF Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - physiology BACE1 Basal forebrain cholinergic neurons Choline O-Acetyltransferase - metabolism Cholinergic Neurons - pathology Disease Models, Animal Down Syndrome - genetics Down Syndrome - pathology Endosomes Endosomes - genetics Endosomes - pathology Gene Deletion Genetic Association Studies Internal Medicine Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Nerve Degeneration - genetics Nerve Degeneration - pathology Neurology Septal Nuclei - cytology Septal Nuclei - enzymology Trisomic mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!