The Structure of the Candida albicans Ess1 Prolyl Isomerase Reveals a Well-Ordered Linker that Restricts Domain Mobility

Ess1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that binds to the carboxy-terminal domain (CTD) of RNA polymerase II. Ess1 is thought to function by inducing conformational changes in the CTD that control the assembly of cofactor complexes on the transcription unit. Ess1 (also called Pin1) is...

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Veröffentlicht in:	Biochemistry (Easton) 2005-04, Vol.44 (16), p.6180-6189
Hauptverfasser:	Li, Zhong, Li, Hongmin, Devasahayam, Gina, Gemmill, Trent, Chaturvedi, Vishnu, Hanes, Steven D, Van Roey, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Candida albicans - enzymology Candida albicans - genetics Candida albicans - pathogenicity Crystallography, X-Ray Female Genes, Fungal Humans Mice Mice, Inbred BALB C Models, Molecular Molecular Sequence Data Molecular Structure Mutation NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase - chemistry Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - physiology Protein Conformation Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Sequence Homology, Amino Acid Virulence - genetics Virulence - physiology
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