Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2

Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not clearly understood. In particular, the conventional...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2011-07, Vol.118 (2), p.416-424
Hauptverfasser:	Konopatskaya, Olga, Matthews, Sharon A., Harper, Matthew T., Gilio, Karen, Cosemans, Judith M.E.M., Williams, Christopher M., Navarro, Maria N., Carter, Deborah A., Heemskerk, Johan W.M., Leitges, Michael, Cantrell, Doreen, Poole, Alastair W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Platelets - drug effects Blood Platelets - enzymology Blood Platelets - metabolism Female Gene Expression Regulation, Enzymologic Hematologic and hematopoietic diseases Humans Indoles - pharmacology Male Maleimides - pharmacology Medical sciences Mice Mice, Knockout Platelet Activation - drug effects Platelet Activation - genetics Platelet Aggregation - drug effects Platelet Aggregation - genetics Platelet Aggregation - physiology Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - metabolism Protein Kinase C - physiology Protein Kinase D2 Protein Kinase Inhibitors - pharmacology Protein Kinases - genetics Protein Kinases - metabolism Protein Kinases - physiology Secretory Vesicles - drug effects Secretory Vesicles - metabolism Signal Transduction - drug effects Thrombosis - genetics Thrombosis - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!