Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and c...

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Veröffentlicht in:	Cancers 2016-02, Vol.8 (2), p.22
Hauptverfasser:	Rimkus, Tadas K, Carpenter, Richard L, Qasem, Shadi, Chan, Michael, Lo, Hui-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cancer therapies Cell growth Cellular biology Review
Online-Zugang:	Volltext
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