Clinical Characteristics Associated with Antibiotic Treatment Failure for Tuboovarian Abscesses
Objective. Although parenteral antibiotic treatment is a standard approach for tuboovarian abscesses, a significant proportion of patients fail therapy and require interventional radiology (IR) guided drainage. The objective of this study is to assess if specific clinical factors are associated with...
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| Veröffentlicht in: | Infectious Diseases in Obstetrics and Gynecology 2016, Vol.2016 (2016), p.104-110 |
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| creator | Styer, Aaron K. Karmon, Anatte E. Lau, Trevin C. Farid, Huma |
| description | Objective. Although parenteral antibiotic treatment is a standard approach for tuboovarian abscesses, a significant proportion of patients fail therapy and require interventional radiology (IR) guided drainage. The objective of this study is to assess if specific clinical factors are associated with antibiotic treatment failure. Study Design. Retrospective medical record review of patients hospitalized for tuboovarian abscesses from 2001 through 2012 was performed. Clinical characteristics were compared for patients who underwent successful parenteral antibiotic treatment, failed antibiotic treatment necessitating subsequent IR drainage, initial drainage with concurrent antibiotics, and surgery. Results. One hundred thirteen patients admitted for inpatient treatment were identified. Sixty-one (54%) patients were treated with antibiotics alone. Within this group, 24.6% failed antibiotic treatment and required drainage. Mean white blood cell count (K/μL) (18.7±5.94 versus 13.9±5.12) (p=0.003), mean maximum diameter of tuboovarian abscess (cm) (6.8±2.9 versus 5.2±2.0) (p=0.03), and length of stay (days) (9.47±7.43 versus 4.59±2.4) (p=0.002) were significantly greater for patients who failed antibiotic treatment. Conclusions. Admission white blood cell count greater than 16 K/μL and abscess size greater than 5.18 cm are associated with antibiotic treatment failure. These factors may provide guidance for initial selection of IR guided drainage. |
| doi_str_mv | 10.1155/2016/5120293 |
| format | Article |
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Although parenteral antibiotic treatment is a standard approach for tuboovarian abscesses, a significant proportion of patients fail therapy and require interventional radiology (IR) guided drainage. The objective of this study is to assess if specific clinical factors are associated with antibiotic treatment failure. Study Design. Retrospective medical record review of patients hospitalized for tuboovarian abscesses from 2001 through 2012 was performed. Clinical characteristics were compared for patients who underwent successful parenteral antibiotic treatment, failed antibiotic treatment necessitating subsequent IR drainage, initial drainage with concurrent antibiotics, and surgery. Results. One hundred thirteen patients admitted for inpatient treatment were identified. Sixty-one (54%) patients were treated with antibiotics alone. Within this group, 24.6% failed antibiotic treatment and required drainage. Mean white blood cell count (K/μL) (18.7±5.94 versus 13.9±5.12) (p=0.003), mean maximum diameter of tuboovarian abscess (cm) (6.8±2.9 versus 5.2±2.0) (p=0.03), and length of stay (days) (9.47±7.43 versus 4.59±2.4) (p=0.002) were significantly greater for patients who failed antibiotic treatment. Conclusions. Admission white blood cell count greater than 16 K/μL and abscess size greater than 5.18 cm are associated with antibiotic treatment failure. These factors may provide guidance for initial selection of IR guided drainage.</description><identifier>ISSN: 1064-7449</identifier><identifier>EISSN: 1098-0997</identifier><identifier>DOI: 10.1155/2016/5120293</identifier><identifier>PMID: 26989337</identifier><identifier>CODEN: IDOGEX</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Abscess - drug therapy ; Abscess - physiopathology ; Adolescent ; Adult ; Aged ; Analysis ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Care and treatment ; Drug therapy ; Fallopian Tube Diseases - drug therapy ; Fallopian Tube Diseases - physiopathology ; Female ; Humans ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Ovarian diseases ; Ovarian Diseases - drug therapy ; Ovarian Diseases - physiopathology ; Patients ; Reproductive system ; Retrospective Studies ; Treatment Failure ; Treatment outcome ; Ultrasonic imaging ; Womens health ; Young Adult</subject><ispartof>Infectious Diseases in Obstetrics and Gynecology, 2016, Vol.2016 (2016), p.104-110</ispartof><rights>Copyright © 2016 Huma Farid et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright Hindawi Publishing Corporation 2016</rights><rights>Copyright © 2016 Huma Farid et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a5533-e7d7f603ab493bc23a27e4af6cce05ce475fa3721e22dcfec832dd3b96cdb24c3</citedby><cites>FETCH-LOGICAL-a5533-e7d7f603ab493bc23a27e4af6cce05ce475fa3721e22dcfec832dd3b96cdb24c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773533/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773533/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26989337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Donders, Gilbert</contributor><creatorcontrib>Styer, Aaron K.</creatorcontrib><creatorcontrib>Karmon, Anatte E.</creatorcontrib><creatorcontrib>Lau, Trevin C.</creatorcontrib><creatorcontrib>Farid, Huma</creatorcontrib><title>Clinical Characteristics Associated with Antibiotic Treatment Failure for Tuboovarian Abscesses</title><title>Infectious Diseases in Obstetrics and Gynecology</title><addtitle>Infect Dis Obstet Gynecol</addtitle><description>Objective. Although parenteral antibiotic treatment is a standard approach for tuboovarian abscesses, a significant proportion of patients fail therapy and require interventional radiology (IR) guided drainage. The objective of this study is to assess if specific clinical factors are associated with antibiotic treatment failure. Study Design. Retrospective medical record review of patients hospitalized for tuboovarian abscesses from 2001 through 2012 was performed. Clinical characteristics were compared for patients who underwent successful parenteral antibiotic treatment, failed antibiotic treatment necessitating subsequent IR drainage, initial drainage with concurrent antibiotics, and surgery. Results. One hundred thirteen patients admitted for inpatient treatment were identified. Sixty-one (54%) patients were treated with antibiotics alone. Within this group, 24.6% failed antibiotic treatment and required drainage. Mean white blood cell count (K/μL) (18.7±5.94 versus 13.9±5.12) (p=0.003), mean maximum diameter of tuboovarian abscess (cm) (6.8±2.9 versus 5.2±2.0) (p=0.03), and length of stay (days) (9.47±7.43 versus 4.59±2.4) (p=0.002) were significantly greater for patients who failed antibiotic treatment. Conclusions. Admission white blood cell count greater than 16 K/μL and abscess size greater than 5.18 cm are associated with antibiotic treatment failure. These factors may provide guidance for initial selection of IR guided drainage.</description><subject>Abscess - drug therapy</subject><subject>Abscess - physiopathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Care and treatment</subject><subject>Drug therapy</subject><subject>Fallopian Tube Diseases - drug therapy</subject><subject>Fallopian Tube Diseases - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Ovarian diseases</subject><subject>Ovarian Diseases - drug therapy</subject><subject>Ovarian Diseases - physiopathology</subject><subject>Patients</subject><subject>Reproductive system</subject><subject>Retrospective Studies</subject><subject>Treatment Failure</subject><subject>Treatment outcome</subject><subject>Ultrasonic imaging</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1064-7449</issn><issn>1098-0997</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks2L1DAYh4so7rp68ywFQQSd3TdfTXsRhsFVYUAP4zmk6dvtu3SaNWl38b83dcadHfEgOeTryZPk5ZdlLxmcM6bUBQdWXCjGgVfiUXbKoCoXUFX68Twu5EJLWZ1kz2K8BoASCvU0O-FFVVZC6NPMrHoayNk-X3U2WDdioDiSi_kyRu_IjtjkdzR2-XIYqSaf9vJNQDtucRjzS0v9FDBvfcg3U-39rQ1kh3xZR4cxYnyePWltH_HFvj_Lvl9-3Kw-L9ZfP31ZLdcLq5QQC9SNbgsQtpaVqB0XlmuUti2cQ1AOpVatFZoz5LxxLbpS8KYRdVW4pubSibPsw857M9VbbFx6XLC9uQm0teGn8ZbM8c5Anbnyt0ZqLdILkuDtXhD8jwnjaLaU_tD3dkA_RcO0lkoUDMqEvv4LvfZTGNL3ZgpAg2TVgbqyPRoaWp_udbPULBWoUlSayUSd_4NKrcEtOT9gS2n96MCbBwc6tP3YRd9PI_khHoPvd6ALPsaA7X0xGJg5OWZOjtknJ-GvHhbwHv4TlQS82wEdDY29o__UYWKwtQeagSw1S8B6B1gKNNKhhN-SRzHGBID87WR87jTwlF4AcTxJtlkpfgFMOujW</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Styer, Aaron K.</creator><creator>Karmon, Anatte E.</creator><creator>Lau, Trevin C.</creator><creator>Farid, Huma</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2016</creationdate><title>Clinical Characteristics Associated with Antibiotic Treatment Failure for Tuboovarian Abscesses</title><author>Styer, Aaron K. ; 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Although parenteral antibiotic treatment is a standard approach for tuboovarian abscesses, a significant proportion of patients fail therapy and require interventional radiology (IR) guided drainage. The objective of this study is to assess if specific clinical factors are associated with antibiotic treatment failure. Study Design. Retrospective medical record review of patients hospitalized for tuboovarian abscesses from 2001 through 2012 was performed. Clinical characteristics were compared for patients who underwent successful parenteral antibiotic treatment, failed antibiotic treatment necessitating subsequent IR drainage, initial drainage with concurrent antibiotics, and surgery. Results. One hundred thirteen patients admitted for inpatient treatment were identified. Sixty-one (54%) patients were treated with antibiotics alone. Within this group, 24.6% failed antibiotic treatment and required drainage. Mean white blood cell count (K/μL) (18.7±5.94 versus 13.9±5.12) (p=0.003), mean maximum diameter of tuboovarian abscess (cm) (6.8±2.9 versus 5.2±2.0) (p=0.03), and length of stay (days) (9.47±7.43 versus 4.59±2.4) (p=0.002) were significantly greater for patients who failed antibiotic treatment. Conclusions. Admission white blood cell count greater than 16 K/μL and abscess size greater than 5.18 cm are associated with antibiotic treatment failure. These factors may provide guidance for initial selection of IR guided drainage.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>26989337</pmid><doi>10.1155/2016/5120293</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abscess - drug therapy Abscess - physiopathology Adolescent Adult Aged Analysis Anti-Bacterial Agents - therapeutic use Antibiotics Care and treatment Drug therapy Fallopian Tube Diseases - drug therapy Fallopian Tube Diseases - physiopathology Female Humans Middle Aged NMR Nuclear magnetic resonance Ovarian diseases Ovarian Diseases - drug therapy Ovarian Diseases - physiopathology Patients Reproductive system Retrospective Studies Treatment Failure Treatment outcome Ultrasonic imaging Womens health Young Adult |
| title | Clinical Characteristics Associated with Antibiotic Treatment Failure for Tuboovarian Abscesses |
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