Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation

RATIONALE:Telomerase is a nuclear regulator of telomere elongation with recent reports suggesting a role in regulation of mitochondrial reactive oxygen species. Flow-mediated dilation in patients with cardiovascular disease is dependent on the formation of reactive oxygen species. OBJECTIVE:We exami...

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Veröffentlicht in:	Circulation research 2016-03, Vol.118 (5), p.856-866
Hauptverfasser:	Beyer, Andreas M, Freed, Julie K, Durand, Matthew J, Riedel, Michael, Ait-Aissa, Karima, Green, Paula, Hockenberry, Joseph C, Morgan, R Garret, Donato, Anthony J, Peleg, Refael, Gasparri, Mario, Rokkas, Chris K, Santos, Janine H, Priel, Esther, Gutterman, David D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - blood supply Adipose Tissue - enzymology Aged Arterioles - enzymology Blood Flow Velocity - physiology Cells, Cultured Clinical Track Coronary Artery Disease - enzymology Coronary Artery Disease - pathology Coronary Vessels - enzymology Endothelium, Vascular - enzymology Female Human Umbilical Vein Endothelial Cells - enzymology Humans Male Microcirculation - physiology Middle Aged Telomerase - physiology Vasodilation - physiology
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