Abdominal migraine in children: association between gastric motility parameters and clinical characteristics
Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM. Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North...
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| Veröffentlicht in: | BMC gastroenterology 2016-02, Vol.16 (29), p.26-26, Article 26 |
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| description | Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM.
Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North Colombo Teaching Hospital Ragama, Sri Lanka, from 2007 to 2012, were screened. Those fulfilling Rome III criteria for AM were recruited after obtaining parental consent. None had clinical or laboratory evidence of organic disorders. Twenty healthy children (8 boys), with an age range of 4-14 years, were recruited as controls. Liquid gastric emptying rate (GE) and antral motility parameters were assessed using an ultrasound method.
Average GE (41.6 % vs. 66.2 %, in controls), amplitude of antral contractions (A) (57.9 % vs. 89.0 %) and antral motility index (MI) (5.0 vs. 8.3) were lower and fasting antral area (1.8 cm(2) vs. 0.6 cm(2)) was higher in children with AM (p < 0.01). No significant difference in the frequency of antral contractions (F) (8.8/3 min vs. 9.3/3 min, p = 0.08) was found between the two groups. Scores obtained for severity of abdominal pain had a negative correlation with A (r = -0.55, p = 0.03). Average duration of abdominal pain episodes correlated with GE (r = -0.58, p = 0.02). Negative correlations were observed between duration of AM and A (r = -0.55), F (r = -0.52), and MI (r = -0.57) (p < 0.05).
GE and antral motility parameters were significantly lower in children with AM. A significant correlation was found between symptoms and gastric motility. These findings suggest a possible role of abnormal gastric motility in the pathogenesis of AM. |
| doi_str_mv | 10.1186/s12876-016-0435-2 |
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Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North Colombo Teaching Hospital Ragama, Sri Lanka, from 2007 to 2012, were screened. Those fulfilling Rome III criteria for AM were recruited after obtaining parental consent. None had clinical or laboratory evidence of organic disorders. Twenty healthy children (8 boys), with an age range of 4-14 years, were recruited as controls. Liquid gastric emptying rate (GE) and antral motility parameters were assessed using an ultrasound method.
Average GE (41.6 % vs. 66.2 %, in controls), amplitude of antral contractions (A) (57.9 % vs. 89.0 %) and antral motility index (MI) (5.0 vs. 8.3) were lower and fasting antral area (1.8 cm(2) vs. 0.6 cm(2)) was higher in children with AM (p < 0.01). No significant difference in the frequency of antral contractions (F) (8.8/3 min vs. 9.3/3 min, p = 0.08) was found between the two groups. Scores obtained for severity of abdominal pain had a negative correlation with A (r = -0.55, p = 0.03). Average duration of abdominal pain episodes correlated with GE (r = -0.58, p = 0.02). Negative correlations were observed between duration of AM and A (r = -0.55), F (r = -0.52), and MI (r = -0.57) (p < 0.05).
GE and antral motility parameters were significantly lower in children with AM. A significant correlation was found between symptoms and gastric motility. These findings suggest a possible role of abnormal gastric motility in the pathogenesis of AM.</description><identifier>ISSN: 1471-230X</identifier><identifier>EISSN: 1471-230X</identifier><identifier>DOI: 10.1186/s12876-016-0435-2</identifier><identifier>PMID: 26924750</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Abdomen ; Abdominal pain ; Adolescent ; Care and treatment ; Case-Control Studies ; Causes of ; Child ; Child, Preschool ; Cohort Studies ; Confidence intervals ; Diagnosis ; Digestive system ; Disease ; Fasting ; Female ; Gastric Emptying - physiology ; Gastroenterology ; Gastrointestinal Motility - physiology ; Gastrointestinal system ; Headaches ; Humans ; Irritable bowel syndrome ; Male ; Migraine ; Migraine Disorders - diagnostic imaging ; Migraine Disorders - physiopathology ; Motility ; Muscle Contraction - physiology ; Physiology ; Pyloric Antrum - diagnostic imaging ; Pyloric Antrum - physiopathology ; Severity of Illness Index ; Sri Lanka ; Stomach - diagnostic imaging ; Stomach - physiopathology ; Studies ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>BMC gastroenterology, 2016-02, Vol.16 (29), p.26-26, Article 26</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Devanarayana et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-858bdd0507c59c9d805a86d4cfeb09fd36295d9de82fbf03cbef867a1c6f53233</citedby><cites>FETCH-LOGICAL-c494t-858bdd0507c59c9d805a86d4cfeb09fd36295d9de82fbf03cbef867a1c6f53233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770524/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770524/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26924750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devanarayana, Niranga Manjuri</creatorcontrib><creatorcontrib>Rajindrajith, Shaman</creatorcontrib><creatorcontrib>Benninga, Marc A</creatorcontrib><title>Abdominal migraine in children: association between gastric motility parameters and clinical characteristics</title><title>BMC gastroenterology</title><addtitle>BMC Gastroenterol</addtitle><description>Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM.
Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North Colombo Teaching Hospital Ragama, Sri Lanka, from 2007 to 2012, were screened. Those fulfilling Rome III criteria for AM were recruited after obtaining parental consent. None had clinical or laboratory evidence of organic disorders. Twenty healthy children (8 boys), with an age range of 4-14 years, were recruited as controls. Liquid gastric emptying rate (GE) and antral motility parameters were assessed using an ultrasound method.
Average GE (41.6 % vs. 66.2 %, in controls), amplitude of antral contractions (A) (57.9 % vs. 89.0 %) and antral motility index (MI) (5.0 vs. 8.3) were lower and fasting antral area (1.8 cm(2) vs. 0.6 cm(2)) was higher in children with AM (p < 0.01). No significant difference in the frequency of antral contractions (F) (8.8/3 min vs. 9.3/3 min, p = 0.08) was found between the two groups. Scores obtained for severity of abdominal pain had a negative correlation with A (r = -0.55, p = 0.03). Average duration of abdominal pain episodes correlated with GE (r = -0.58, p = 0.02). Negative correlations were observed between duration of AM and A (r = -0.55), F (r = -0.52), and MI (r = -0.57) (p < 0.05).
GE and antral motility parameters were significantly lower in children with AM. A significant correlation was found between symptoms and gastric motility. These findings suggest a possible role of abnormal gastric motility in the pathogenesis of AM.</description><subject>Abdomen</subject><subject>Abdominal pain</subject><subject>Adolescent</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Causes of</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Digestive system</subject><subject>Disease</subject><subject>Fasting</subject><subject>Female</subject><subject>Gastric Emptying - physiology</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Gastrointestinal system</subject><subject>Headaches</subject><subject>Humans</subject><subject>Irritable bowel syndrome</subject><subject>Male</subject><subject>Migraine</subject><subject>Migraine Disorders - diagnostic imaging</subject><subject>Migraine Disorders - physiopathology</subject><subject>Motility</subject><subject>Muscle Contraction - physiology</subject><subject>Physiology</subject><subject>Pyloric Antrum - diagnostic imaging</subject><subject>Pyloric Antrum - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Sri Lanka</subject><subject>Stomach - diagnostic imaging</subject><subject>Stomach - physiopathology</subject><subject>Studies</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>1471-230X</issn><issn>1471-230X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl1rHCEUhofS0KRpf0BvitCb3kzi1-jYi8IS-gWB3rTQO3HU2T3B0a26Kfn3ddk0TUIQUc553lc8vF33huAzQkZxXggdpegxaZuzoafPuhPCJekpw7-e37sfdy9LucKYyJGyF90xFYpyOeCTLqwmlxaIJqAF1tlA9AgishsILvv4AZlSkgVTIUU0-frH-4jWptQMFi2pQoB6g7Ymm8VXnwsy0SEbIIJtlnbTGrbVoVSw5VV3NJtQ_Ovb87T7-fnTj4uv_eX3L98uVpe95YrXfhzGyTk8YGkHZZUb8WBG4bid_YTV7JiganDK-ZHO04yZnfw8CmmIFfPAKGOn3ceD73Y3Ld5ZH2s2QW8zLCbf6GRAP-xE2Oh1utZcSjxQ3gze3xrk9HvnS9ULFOtDMNGnXdFECiWI4kw19N0j9CrtcpvnnpJMKtKG_Z9am-A1xDm1d-3eVK8454JyoXCjzp6g2nJ-AZuin6HVHwjIQWBzKiX7-e6PBOt9RPQhIrpFRO8jomnTvL0_nDvFv0ywv2IluP0</recordid><startdate>20160229</startdate><enddate>20160229</enddate><creator>Devanarayana, Niranga Manjuri</creator><creator>Rajindrajith, Shaman</creator><creator>Benninga, Marc A</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160229</creationdate><title>Abdominal migraine in children: association between gastric motility parameters and clinical characteristics</title><author>Devanarayana, Niranga Manjuri ; Rajindrajith, Shaman ; Benninga, Marc A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-858bdd0507c59c9d805a86d4cfeb09fd36295d9de82fbf03cbef867a1c6f53233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdomen</topic><topic>Abdominal pain</topic><topic>Adolescent</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Causes of</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Digestive system</topic><topic>Disease</topic><topic>Fasting</topic><topic>Female</topic><topic>Gastric Emptying - physiology</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Gastrointestinal system</topic><topic>Headaches</topic><topic>Humans</topic><topic>Irritable bowel syndrome</topic><topic>Male</topic><topic>Migraine</topic><topic>Migraine Disorders - diagnostic imaging</topic><topic>Migraine Disorders - physiopathology</topic><topic>Motility</topic><topic>Muscle Contraction - physiology</topic><topic>Physiology</topic><topic>Pyloric Antrum - diagnostic imaging</topic><topic>Pyloric Antrum - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Sri Lanka</topic><topic>Stomach - diagnostic imaging</topic><topic>Stomach - physiopathology</topic><topic>Studies</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devanarayana, Niranga Manjuri</creatorcontrib><creatorcontrib>Rajindrajith, Shaman</creatorcontrib><creatorcontrib>Benninga, Marc A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devanarayana, Niranga Manjuri</au><au>Rajindrajith, Shaman</au><au>Benninga, Marc A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abdominal migraine in children: association between gastric motility parameters and clinical characteristics</atitle><jtitle>BMC gastroenterology</jtitle><addtitle>BMC Gastroenterol</addtitle><date>2016-02-29</date><risdate>2016</risdate><volume>16</volume><issue>29</issue><spage>26</spage><epage>26</epage><pages>26-26</pages><artnum>26</artnum><issn>1471-230X</issn><eissn>1471-230X</eissn><abstract>Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM.
Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North Colombo Teaching Hospital Ragama, Sri Lanka, from 2007 to 2012, were screened. Those fulfilling Rome III criteria for AM were recruited after obtaining parental consent. None had clinical or laboratory evidence of organic disorders. Twenty healthy children (8 boys), with an age range of 4-14 years, were recruited as controls. Liquid gastric emptying rate (GE) and antral motility parameters were assessed using an ultrasound method.
Average GE (41.6 % vs. 66.2 %, in controls), amplitude of antral contractions (A) (57.9 % vs. 89.0 %) and antral motility index (MI) (5.0 vs. 8.3) were lower and fasting antral area (1.8 cm(2) vs. 0.6 cm(2)) was higher in children with AM (p < 0.01). No significant difference in the frequency of antral contractions (F) (8.8/3 min vs. 9.3/3 min, p = 0.08) was found between the two groups. Scores obtained for severity of abdominal pain had a negative correlation with A (r = -0.55, p = 0.03). Average duration of abdominal pain episodes correlated with GE (r = -0.58, p = 0.02). Negative correlations were observed between duration of AM and A (r = -0.55), F (r = -0.52), and MI (r = -0.57) (p < 0.05).
GE and antral motility parameters were significantly lower in children with AM. A significant correlation was found between symptoms and gastric motility. These findings suggest a possible role of abnormal gastric motility in the pathogenesis of AM.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26924750</pmid><doi>10.1186/s12876-016-0435-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerNature Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abdomen Abdominal pain Adolescent Care and treatment Case-Control Studies Causes of Child Child, Preschool Cohort Studies Confidence intervals Diagnosis Digestive system Disease Fasting Female Gastric Emptying - physiology Gastroenterology Gastrointestinal Motility - physiology Gastrointestinal system Headaches Humans Irritable bowel syndrome Male Migraine Migraine Disorders - diagnostic imaging Migraine Disorders - physiopathology Motility Muscle Contraction - physiology Physiology Pyloric Antrum - diagnostic imaging Pyloric Antrum - physiopathology Severity of Illness Index Sri Lanka Stomach - diagnostic imaging Stomach - physiopathology Studies Ultrasonic imaging Ultrasonography |
| title | Abdominal migraine in children: association between gastric motility parameters and clinical characteristics |
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