Targeting the tumour microenvironment in ovarian cancer
Abstract The study of cancer initiation, growth, and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to uncontrolled growth signalling owing to genetic derangements. However, uncontrolled growth in tumours cannot be explained solely by aberrations in...
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| Veröffentlicht in: | European journal of cancer (1990) 2016-03, Vol.56, p.131-143 |
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| container_title | European journal of cancer (1990) |
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| creator | Hansen, Jean M Coleman, Robert L Sood, Anil K |
| description | Abstract The study of cancer initiation, growth, and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to uncontrolled growth signalling owing to genetic derangements. However, uncontrolled growth in tumours cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype. Ovarian cancer is the leading cause of death from gynaecologic cancer worldwide. The majority of patients will have objective responses to standard tumour debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumour microenvironment in ovarian cancer. Herein, we review the key components of the tumour microenvironment as they pertain to this disease, outline targeting opportunities and supporting evidence thus far, and discuss resistance to therapy. |
| doi_str_mv | 10.1016/j.ejca.2015.12.016 |
| format | Article |
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However, uncontrolled growth in tumours cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype. Ovarian cancer is the leading cause of death from gynaecologic cancer worldwide. The majority of patients will have objective responses to standard tumour debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumour microenvironment in ovarian cancer. 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However, uncontrolled growth in tumours cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype. Ovarian cancer is the leading cause of death from gynaecologic cancer worldwide. The majority of patients will have objective responses to standard tumour debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumour microenvironment in ovarian cancer. Herein, we review the key components of the tumour microenvironment as they pertain to this disease, outline targeting opportunities and supporting evidence thus far, and discuss resistance to therapy.</description><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Carcinoma, Ovarian Epithelial</subject><subject>Cell Proliferation - drug effects</subject><subject>Drug Resistance, Neoplasm</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Female</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - pathology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasms, Glandular and Epithelial - blood supply</subject><subject>Neoplasms, Glandular and Epithelial - drug therapy</subject><subject>Neoplasms, Glandular and Epithelial - immunology</subject><subject>Neoplasms, Glandular and Epithelial - metabolism</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Neovascularization, Pathologic</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - blood supply</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - immunology</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Signal Transduction - drug effects</subject><subject>Tumor Burden - drug effects</subject><subject>Tumor Microenvironment - drug effects</subject><subject>Tumour microenvironment</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1TAQtBCIPgp_gAPKkUvCrmPHtoQqoYovqRIHytnyc5xXh8QudvKk_vs6eqUCDlzW0u7M7HqGkNcIDQJ278bGjdY0FJA3SJvSekJ2KIWqQXL6lOxAcVVLYOqMvMh5BAAhGTwnZ7STTEErdkRcm3Rwiw-Harlx1bLOcU3V7G2KLhx9imF2Yal8qOLRJG9CZU2wLr0kzwYzZffq4T0nPz59vL78Ul99-_z18sNVbTnCUjNkDKygUgrTo9lLxYURXHGKpbIOxFAqNVI5wTox7BGkHCyVwsoeWNuek4uT7u26n11vyzHJTPo2-dmkOx2N139Pgr_Rh3jUTHRKUSwCbx8EUvy1urzo2WfrpskEF9esUXSSc9HybRc9Qcvnc05ueFyDoDfH9ag3x_XmuEaqS6uQ3vx54CPlt8UF8P4EcMWmo3dJZ-td8bD3ydlF99H_X__iH7qdfPDWTD_dnctjiSuUADTqXAj6-5b5FjlyQOwA2nsyYqZD</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Hansen, Jean M</creator><creator>Coleman, Robert L</creator><creator>Sood, Anil K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Targeting the tumour microenvironment in ovarian cancer</title><author>Hansen, Jean M ; 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However, uncontrolled growth in tumours cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype. Ovarian cancer is the leading cause of death from gynaecologic cancer worldwide. The majority of patients will have objective responses to standard tumour debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumour microenvironment in ovarian cancer. 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| issn | 0959-8049 1879-0852 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angiogenesis Inhibitors - therapeutic use Animals Antineoplastic Agents - therapeutic use Carcinoma, Ovarian Epithelial Cell Proliferation - drug effects Drug Resistance, Neoplasm Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Hematology, Oncology and Palliative Medicine Humans Molecular Targeted Therapy Neoplasms, Glandular and Epithelial - blood supply Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - immunology Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Neovascularization, Pathologic Ovarian cancer Ovarian Neoplasms - blood supply Ovarian Neoplasms - drug therapy Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Signal Transduction - drug effects Tumor Burden - drug effects Tumor Microenvironment - drug effects Tumour microenvironment |
| title | Targeting the tumour microenvironment in ovarian cancer |
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