Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects

APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome Study Network (NEPTUNE), stratified by APOL1...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2016-03, Vol.27 (3), p.814-823
Hauptverfasser:	Sampson, Matthew G, Robertson, Catherine C, Martini, Sebastian, Mariani, Laura H, Lemley, Kevin V, Gillies, Christopher E, Otto, Edgar A, Kopp, Jeffrey B, Randolph, Anne, Vega-Warner, Virginia, Eichinger, Felix, Nair, Viji, Gipson, Debbie S, Cattran, Daniel C, Johnstone, Duncan B, O'Toole, John F, Bagnasco, Serena M, Song, Peter X, Barisoni, Laura, Troost, Jonathan P, Kretzler, Matthias, Sedor, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult African Americans - genetics Alleles Apolipoprotein L1 Apolipoproteins - genetics Atrophy - genetics Basic Research Biopsy Chemokine CXCL11 - genetics Chemokine CXCL9 - genetics Child Female Fibrosis Gene Expression Genomics - methods Genotype Glomerular Filtration Rate - genetics Humans Kidney Glomerulus - physiopathology Kidney Tubules - metabolism Kidney Tubules - pathology Kidney Tubules - physiopathology Lipoproteins, HDL - genetics Male Middle Aged Mucins - genetics Nephrotic Syndrome - genetics Nephrotic Syndrome - pathology Nephrotic Syndrome - physiopathology Proteinuria - genetics Risk Factors RNA, Messenger - metabolism Transcriptome Ubiquitins - genetics Young Adult
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