Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa

The Fc region of Immunoglobulin G (IgG) initiates inflammatory responses such as antibody-dependent cell-mediated cytotoxicity (ADCC) through binding to activating Fc receptors (FcγRI, FcγRIIa, FcγRIIIa). These receptors are expressed on the surface of immune cells including macrophages, dendritic c...

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Veröffentlicht in:	Journal of structural biology 2016-04, Vol.194 (1), p.78-89
Hauptverfasser:	Ahmed, Alysia A., Keremane, Sravya R., Vielmetter, Jost, Bjorkman, Pamela J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Antibody-Dependent Cell Cytotoxicity Binding Sites - genetics Crystallography, X-Ray Fc receptors Fc–FcR structure Fucose - metabolism GASDALIE Fc Glycosylation HEK293 Cells Humans IgG Fc Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - metabolism Models, Molecular Mutation Protein Binding Protein Domains Receptors, IgG - chemistry Receptors, IgG - genetics Receptors, IgG - metabolism SDALIE Fc Sequence Homology, Amino Acid Surface Plasmon Resonance
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