A Multi-RNAi Microsponge Platform for Simultaneous Controlled Delivery of Multiple Small Interfering RNAs

Packaging multiple small interfering RNA (siRNA) molecules into nanostructures at precisely defined ratios is a powerful delivery strategy for effective RNA interference (RNAi) therapy. We present a novel RNA nanotechnology based approach to produce multiple components of polymerized siRNA molecules...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-03, Vol.55 (10), p.3347-3351
Hauptverfasser:	Roh, Young Hoon, Deng, Jason Z., Dreaden, Erik C., Park, Jae Hyon, Yun, Dong Soo, Shopsowitz, Kevin E., Hammond, Paula T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical materials Cancer Circular DNA Circularity Communication Communications Condensation Deoxyribonucleic acid Disorders DNA DNA/RNA nanotechnology Gene expression Genes Genetic disorders Interference Microscopy, Electron, Scanning Microstructure multifunctionality Nanotechnology Packaging Physicochemical properties Polyelectrolytes Polymerization Ribonucleic acid RNA RNA Interference RNA, Small Interfering - administration & dosage RNA-mediated interference siRNA siRNA delivery Stoichiometry Surface charge Therapy Transcription
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