Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

Purpose nab -paclitaxel demonstrates improved clinical efficacy compared with conventional Cremophor EL (CrEL)-paclitaxel in multiple tumor types. This study explored the distinctions in drug distribution between nab -paclitaxel and CrEL-paclitaxel and the underlying mechanisms. Methods Uptake and t...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2015-10, Vol.76 (4), p.699-712
Hauptverfasser:	Chen, Nianhang, Brachmann, Carrie, Liu, Xiping, Pierce, Daniel W., Dey, Joyoti, Kerwin, William S., Li, Yan, Zhou, Simon, Hou, Shihe, Carleton, Michael, Klinghoffer, Richard A., Palmisano, Maria, Chopra, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Biological Transport - drug effects Cancer Research Capillary Permeability - drug effects Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - pathology Cell Line, Tumor Cells, Cultured Drug Delivery Systems Endosomes - drug effects Endosomes - metabolism Endosomes - pathology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Infusions, Intravenous Medicine Medicine & Public Health Mice, Nude Microinjections Nanoparticles - chemistry Oncology Original Original Article Paclitaxel - administration & dosage Paclitaxel - metabolism Paclitaxel - pharmacokinetics Paclitaxel - therapeutic use Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pharmacology/Toxicology Serum Albumin - chemistry Serum Albumin - metabolism Serum Albumin, Human Tissue Distribution Tubulin Modulators - administration & dosage Tubulin Modulators - metabolism Tubulin Modulators - pharmacokinetics Tubulin Modulators - therapeutic use Xenograft Model Antitumor Assays
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