Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has suggested that subcellular microcalcifications in the fibrous cap may promote material failure of the plaque, but that large calcifications c...

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Veröffentlicht in:	Nature materials 2016-03, Vol.15 (3), p.335-343
Hauptverfasser:	Hutcheson, Joshua D., Goettsch, Claudia, Bertazzo, Sergio, Maldonado, Natalia, Ruiz, Jessica L., Goh, Wilson, Yabusaki, Katsumi, Faits, Tyler, Bouten, Carlijn, Franck, Gregory, Quillard, Thibaut, Libby, Peter, Aikawa, Masanori, Weinbaum, Sheldon, Aikawa, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	140/146 639/166 639/301/54 Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis Atherosclerosis - metabolism Biomaterials Calcification Calcium - metabolism Carotid Arteries - pathology Collagen Collagen - metabolism Collagens Condensed Matter Physics Coronary Disease - metabolism Extracellular Matrix Extracellular Vesicles - physiology Failure Formations Genesis Health risks Humans Hydrogels Materials Science Mice Mice, Knockout Minerals Nanotechnology Optical and Electronic Materials Stress analysis Three dimensional
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