An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

Bradley Bernstein, Birgit Knoechel and colleagues identify super-enhancer translocations that drive overexpression of MYB in adenoid cystic carcinoma (ACC). They find that MYB binds to the translocated enhancers and to other active enhancers that drive different regulatory programs in alternate cell...

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Veröffentlicht in:	Nature genetics 2016-03, Vol.48 (3), p.265-272
Hauptverfasser:	Drier, Yotam, Cotton, Matthew J, Williamson, Kaylyn E, Gillespie, Shawn M, Ryan, Russell J H, Kluk, Michael J, Carey, Christopher D, Rodig, Scott J, Sholl, Lynette M, Afrogheh, Amir H, Faquin, William C, Queimado, Lurdes, Qi, Jun, Wick, Michael J, El-Naggar, Adel K, Bradner, James E, Moskaluk, Christopher A, Aster, Jon C, Knoechel, Birgit, Bernstein, Bradley E
Format:	Artikel
Sprache:	eng
Schlagworte:	49/15 49/23 631/1647/1407/1555 631/208/177 Agriculture Animal Genetics and Genomics Biomedicine Cancer Cancer Research Cancer therapies Carcinoma Carcinoma, Adenoid Cystic - genetics Carcinoma, Adenoid Cystic - pathology Cell Line, Tumor Cell Lineage - genetics Chromatin - genetics Development and progression Enhancer Elements, Genetic Gene expression Gene Expression Regulation, Neoplastic Gene Function Gene loci Genetic aspects Genomes Health aspects Human Genetics Humans Kinases Leukemia Oncogene Proteins v-myb - biosynthesis Oncogene Proteins v-myb - genetics Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Oncogenes Proteins Studies Transcription Factors - biosynthesis Translocation Translocation, Genetic Tumor Suppressor Proteins - biosynthesis Tumors
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