A combined binary interaction and phenotypic map of C. elegans cell polarity proteins

The establishment of cell polarity is an essential process for the development of multicellular organisms and the functioning of cells and tissues. Here, we combine large-scale protein interaction mapping with systematic phenotypic profiling to study the network of physical interactions that underli...

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Veröffentlicht in:	Nature cell biology 2016-03, Vol.18 (3), p.337-346
Hauptverfasser:	Koorman, Thijs, Klompstra, Diana, van der Voet, Monique, Lemmens, Irma, Ramalho, João J., Nieuwenhuize, Susan, van den Heuvel, Sander, Tavernier, Jan, Nance, Jeremy, Boxem, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/89 14/35 14/63 49/111 49/47 631/136/334/1582/712 631/337/505 631/80/85 64/11 Animals Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cancer Research Cell Biology Cell Polarity - physiology Developmental Biology Embryo, Nonmammalian - metabolism Genetic aspects GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Identification and classification Life Sciences Observations Phenotype Protein-protein interactions resource RNA Interference - physiology Stem Cells Yeasts
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