TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Our neoadjuvant clinical trial of a GM-CSF secreting allogeneic pancreas tumor vaccine (GVAX) revealed the development of tertiary lymphoid aggregates (TLAs) within the pancreatic ductal adenocarcinoma (PDA) tumor microenvironment 2 weeks after GVAX treatment. Microarray studies revealed that multip...

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Veröffentlicht in:	Oncotarget 2015-12, Vol.6 (40), p.43005-43015
Hauptverfasser:	Soares, Kevin C, Rucki, Agnieszka A, Kim, Victoria, Foley, Kelly, Solt, Sara, Wolfgang, Christopher L, Jaffee, Elizabeth M, Zheng, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Neutralizing - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Cancer Vaccines - administration & dosage Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - pathology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Lymphocytes, Tumor-Infiltrating - drug effects Mice Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Research Paper T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta - antagonists & inhibitors
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