Neonatal thymectomy reveals differentiation and plasticity within human naive T cells

The generation of naive T cells is dependent on thymic output, but in adults, the naive T cell pool is primarily maintained by peripheral proliferation. Naive T cells have long been regarded as relatively quiescent cells; however, it was recently shown that IL-8 production is a signatory effector fu...

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Veröffentlicht in:The Journal of clinical investigation 2016-03, Vol.126 (3), p.1126-1136
Hauptverfasser: van den Broek, Theo, Delemarre, Eveline M, Janssen, Willemijn J M, Nievelstein, Rutger A J, Broen, Jasper C, Tesselaar, Kiki, Borghans, Jose A M, Nieuwenhuis, Edward E S, Prakken, Berent J, Mokry, Michal, Jansen, Nicolaas J G, van Wijk, Femke
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Sprache:eng
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