The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem
Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Amo...
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| Veröffentlicht in: | International Journal of Peptides 2016, Vol.2016, p.1-5-002 |
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| container_title | International Journal of Peptides |
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| creator | Moriyasu, Kazuki Ichinose, Takashi Nakahata, Akane Tanaka, Mitsuru Matsui, Toshiro Furuya, Shigeki |
| description | Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally. |
| doi_str_mv | 10.1155/2016/6020786 |
| format | Article |
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In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally.</description><identifier>ISSN: 1687-9767</identifier><identifier>EISSN: 1687-9775</identifier><identifier>DOI: 10.1155/2016/6020786</identifier><identifier>PMID: 26981137</identifier><language>eng</language><publisher>United States: Hindawi Limiteds</publisher><subject>Brain ; Dopamine ; Electrodes ; Experiments ; Food ; Gene expression ; Health aspects ; Laboratory animals ; Metabolism ; Metabolites ; Neural circuitry ; Parkinson's disease ; Peptides ; Proteins ; Studies</subject><ispartof>International Journal of Peptides, 2016, Vol.2016, p.1-5-002</ispartof><rights>Copyright © 2016 Kazuki Moriyasu et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Kazuki Moriyasu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Kazuki Moriyasu et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a5986-fd835386839f79cc376a995ac4c74da64f5379e476226723eaaed58c56b522103</citedby><cites>FETCH-LOGICAL-a5986-fd835386839f79cc376a995ac4c74da64f5379e476226723eaaed58c56b522103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766323/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766323/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26981137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Taché, Yvette</contributor><creatorcontrib>Moriyasu, Kazuki</creatorcontrib><creatorcontrib>Ichinose, Takashi</creatorcontrib><creatorcontrib>Nakahata, Akane</creatorcontrib><creatorcontrib>Tanaka, Mitsuru</creatorcontrib><creatorcontrib>Matsui, Toshiro</creatorcontrib><creatorcontrib>Furuya, Shigeki</creatorcontrib><title>The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem</title><title>International Journal of Peptides</title><addtitle>Int J Pept</addtitle><description>Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally.</description><subject>Brain</subject><subject>Dopamine</subject><subject>Electrodes</subject><subject>Experiments</subject><subject>Food</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Laboratory animals</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Neural circuitry</subject><subject>Parkinson's disease</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Studies</subject><issn>1687-9767</issn><issn>1687-9775</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1vEzEQhlcIRKvSG2dkiQsSpPXH-uuCVEKASqlAIpwtxzvbuNr1prYD9N_jbUJKK6TaB4_Hz7y2R29VvST4hBDOTykm4lRgiqUST6pDIpScaCn5030s5EF1nNIVLoMpzSV_Xh1QoRUhTB5W3WIF6KNfwzr7BhI672CyuInIhgZ9h3gbz35DzAVK2QeX0axtweWEhoCmNoNbDZ3tfQB0Adkuh86nHvmAchG-GDYJ0IdofUgZ-hfVs9Z2CY5361H149NsMf0ymX_9fD49m08s10pM2kYxzpRQTLdSO8eksFpz62on68aKuuVMaqiloFRIysBaaLhyXCw5pQSzo-r9Vne9WfbQOAg52s6so-9tvDGD9eb-SfArczn8NEVSMMqKwJudQByuN5Cy6X1y0HU2QPmSIYpJxgTm5HFUyppwKQUv6OsH6NWwiaF0olBCaK0pV3fUpe3A-NAO5YluFDVndWmP5EqO1578hyqzgd67IUDrS_5ewbttgYtDShHafTsINqOXzOgls_NSwV_928I9_Nc5BXi7BVY-NPaXf0xuvqWtjz77u49_KxjHCtcY17clhI5LSRBWDPtgQww3GFP2B81Z4lQ</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Moriyasu, Kazuki</creator><creator>Ichinose, Takashi</creator><creator>Nakahata, Akane</creator><creator>Tanaka, Mitsuru</creator><creator>Matsui, Toshiro</creator><creator>Furuya, Shigeki</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>188</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2016</creationdate><title>The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem</title><author>Moriyasu, Kazuki ; 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In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone. In comparison, administration of Ser-Tyr induced significantly increasing noradrenaline turnover, while Tyr-Pro administration suppressed dopamine turnover. Therefore, oral administration of Ile-Tyr, Ser-Tyr, and Tyr-Pro differentially affected metabolism of dopamine and noradrenaline. These observations strongly suggest that Tyr-containing dipeptides exert distinct effects on catecholamine metabolism in the brainstem when ingested orally.</abstract><cop>United States</cop><pub>Hindawi Limiteds</pub><pmid>26981137</pmid><doi>10.1155/2016/6020786</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Brain Dopamine Electrodes Experiments Food Gene expression Health aspects Laboratory animals Metabolism Metabolites Neural circuitry Parkinson's disease Peptides Proteins Studies |
| title | The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem |
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