Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439

Many Actinobacteria, most notably Streptomyces, produce structurally diverse bioactive natural products, including ribosomally synthesized peptides, by multistep enzymatic pathways. The use of site-specific genetic incorporation of unnatural amino acids to investigate and manipulate the functions of...

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Veröffentlicht in:	ACS synthetic biology 2016-02, Vol.5 (2), p.125-132
Hauptverfasser:	He, Jingxuan, Van Treeck, Briana, Nguyen, Han B, Melançon, Charles E
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Phenylalanine - analogs & derivatives Phenylalanine - genetics Phenylalanine - metabolism Streptomyces - genetics Streptomyces - metabolism
Online-Zugang:	Volltext
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